John R. Vane

Research.com Recognitions

• 1998 - Member of the National Academy of Medicine (NAM)
• 1983 - Member of the National Academy of Sciences
• 1982 - Nobel Prize for their discoveries concerning prostaglandins and related biologically active substances
• 1977 - Baly Medal, Royal College of Physicians of London
• 1977 - Albert Lasker Award for Basic Medical Research, Lasker Foundation

Overview

Best Publications

• Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

  J. R. Vane

  14434
  Citations

• An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.

  S. Moncada;R. Gryglewski;S. Bunting;J. R. Vane

  6314
  Citations

• CYCLOOXYGENASES 1 AND 2

  J. R. Vane;Y. S. Bakhle;R. M. Botting

  4100
  Citations

• Regulatory functions of the vascular endothelium.

  John R. Vane;Erik E. Änggård;Regina M. Botting

  2895
  Citations

• EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS

  J. Dyerberg;H.O. Bang;E. Stoffersen;S. Moncada

  2430
  Citations

• Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

  Jane A. Mitchell;Pravit Akarasereenont;Christoph Thiemermann;Roderick J. Flower

  2161
  Citations

• Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

  Timothy D. Warner;Francesco Giuliano;Ivana Vojnovic;Antoaneta Bukasa

  1970
  Citations

• Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

  G de Nucci;R Thomas;P D'Orleans-Juste;E Antunes

  1863
  Citations

• Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

  Ryszard J. Gryglewski;Stuart Bunting;Salvador Moncada;Roderick J. Flower

  1473
  Citations

• The mechanism of action of aspirin.

  J.R Vane;R.M Botting

  1409
  Citations

• Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.

  Stuart Bunting;Salvador Moncada;John R. Vane;Richard Gryglewski

  1389
  Citations

• Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation

  John R. Vane;Jane A. Mitchell;Ian Appleton;Annette Tomlinson

  1350
  Citations

• Indomethacin and aspirin abolish prostaglandin release from the spleen.

  S. H. Ferreira;S. Moncada;J. R. Vane

  1292
  Citations

• HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

  S. Moncada;E.A. Higgs;J.R. Vane

  1254
  Citations

• Prostaglandins: Their Disappearance from and Release into the Circulation

  S. H. Ferreira;J. R. Vane

  1229
  Citations

• Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

  Priscilla J. Piper;J. R. Vane

  1226
  Citations

• New insights into the mode of action of anti-inflammatory drugs

  J. R. Vane;R. M. Botting

  1179
  Citations

• Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol).

  R. J. Flower;J. R. Vane

  1045
  Citations

• Towards a better aspirin

  John Vane

  1039
  Citations

• Anti-inflammatory drugs and their mechanism of action

  J. R. Vane;R. M. Botting

  959
  Citations