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Microbiology

D-Index
53
Citations
7318
World Ranking
4151
National Ranking
370

Overview

John E. Heckels is affiliated with the University of Southampton in the United Kingdom. Their work spans key areas within immunology and microbiology, focusing on bacterial infections and vaccines as well as respiratory and reproductive tract infections.

Their research explores multiple main fields of study, prominently:

  • Immunology and Microbiology
  • Medicine

Within these fields, Heckels' subfields of study include:

  • Microbiology
  • Epidemiology
  • Radiology, Nuclear Medicine and Imaging

The primary topics covered in their research work are:

  • Bacterial Infections and Vaccines
  • Pneumonia and Respiratory Infections
  • Monoclonal and Polyclonal Antibodies Research
  • Reproductive tract infections research

Heckels has published research papers in notable venues such as:

  • Expert Review of Vaccines
  • Frontiers in Bacteriology

Selected recent papers include:

  • The potential utility of liposomes for Neisseria vaccines, 2021, Expert Review of Vaccines
  • An immunoproteomics study of antisera from patients with gonorrhea identifies novel Neisseria gonorrhoeae proteins, 2023, Frontiers in Bacteriology

Their frequent co-authors include:

  • Myron Christodoulides
  • María Victoria Humbert
  • Aiste Dijokaite-Guraliuc
  • Paul Skipp
  • David Cleary

Best Publications

  • Topology of outer membrane porins in pathogenic Neisseria spp.

    P van der Ley;J E Heckels;M Virji;P Hoogerhout

  • Variations in surface protein composition associated with virulence properties in opacity types of Neisseria gonorrhoeae.

    P. R. Lambden;J. E. Heckels;L. T. James;P. J. Watt

  • The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells

    M. Virji;H. Kayhty;D. J. P. Ferguson;C. Alexandrescu

  • Point mutation in meningococcal por A gene associated with increased endemic disease.

    B.T. McGuinness;I.N. Clarke;P.R. Lambden;A.K. Barlow

  • Deduced amino acid sequences of class 1 protein (PorA) from three strains of Neisseria meningitidis. Synthetic peptides define the epitopes responsible for serosubtype specificity.

    Brian McGuinness;Ann K. Barlow;Ian N. Clarke;John E. Farley

  • Class 1 outer membrane protein of Neisseria meningitidis: epitope analysis of the antigenic diversity between strains, implications for subtype definition and molecular epidemiology.

    B. T. McGuinness;P. R. Lambden;J. E. Heckels

  • Antigenic variation during infection with Neisseria gonorrhoeae: detection of antibodies to surface proteins in sera of patients with gonorrhea.

    Unknown

  • The class 1 outer membrane protein of Neisseria meningitidis: gene sequence and structural and immunological similarities to gonococcal porins.

    A. K. Barlow;J. E. Heckels;I. N. Clarke

  • Outer membrane protein composition and colonial morphology of Neisseria gonorrhoeae strain P9

    P.R. Lamden;J.E. Heckels

  • Meningococcal class 1 outer-membrane protein vaccine

    Robert C. Seid;Peter R. Paradiso;Jan T. Poolman;Peter Hoogerhout

  • Immunization with recombinant class 1 outer-membrane protein from Neisseria meningitidis: influence of liposomes and adjuvants on antibody avidity, recognition of native protein and the induction of a bactericidal immune response against meningococci.

    Myron Christodoulides;Joy L. Brooks;Elizabeth Rattue;John E. Heckels

  • Blocking of bactericidal killing of Neisseria meningitidis by antibodies directed against class 4 outer membrane protein.

    A. Munkley;C.R. Tinsley;M. Virji;J.E. Heckels

  • The effect of protein II and pili on the interaction of Neisseria gonorrhoeae with human polymorphonuclear leucocytes.

    Unknown

  • Dynamics of Carriage of Neisseria meningitidis in a Group of Military Recruits: Subtype Stability and Specificity of the Immune Response following Colonization

    G. R. Jones;M. Christodoulides;J. L. Brooks;A. R. O. Miller

  • Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae

    Kevin Maisey;Gino Nardocci;Monica Imarai;Hugo Cardenas

  • Immunization with the recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis

    J. Claire Wright;Jeannette N. Williams;Myron Christodoulides;John E. Heckels

  • Interactions of Neisseria meningitidis with cells of the human meninges

    Samantha J. Hardy;Myron Christodoulides;Roy O. Weller;John E. Heckels

  • Proteomic analysis of outer membranes and vesicles from wild-type serogroup B Neisseria meningitidis and a lipopolysaccharide-deficient mutant.

    Jeannette N. Williams;Paul J. Skipp;Holly E. Humphries;Myron Christodoulides

  • Identification of epitopes recognized by monoclonal antibodies SM1 and SM2 which react with all pili of Neisseria gonorrhoeae but which differentiate between two structural classes of pili expressed by Neisseria meningitidis and the distribution of their encoding sequences in the genomes of Neisseria spp

    Mumtaz Virji;John E. Heckels;Wendy J. Potts;C. A. Hart

  • Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of meningococcal infection.

    Unknown

  • Lyme disease: prevalence and clinical importance of Borrelia burgdorferi specific IgG in forestry workers.

    E.C. Guy;C.N. Martyn;D.E. Bateman;J.E. Heckels

  • Immunization with synthetic peptides containing epitopes of the class 1 outer-membrane protein of Neisseria meningitidis: production of bactericidal antibodies on immunization with a cyclic peptide.

    Myron Christodoulides;Brian T. McGuinness;John E. Heckels

  • Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein.

    Myron Christodoulides;J. Sylvia Everson;Bin L. Liu;Paul R. Lambden

Frequent Co-Authors

Ian N. Clarke
Ian N. Clarke University of Southampton
Paul R. Lambden
Paul R. Lambden Southampton General Hospital
Jon R. Saunders
Jon R. Saunders University of Liverpool
Keith A. Jolley
Keith A. Jolley University of Oxford
Peter S. Friedmann
Peter S. Friedmann University of Southampton
Emmanuel J. H. J. Wiertz
Emmanuel J. H. J. Wiertz Utrecht University
Catherine A. Ison
Catherine A. Ison Public Health England
Craig Winstanley
Craig Winstanley University of Liverpool
Mark Achtman
Mark Achtman University of Warwick
Dominique A. Caugant
Dominique A. Caugant Norwegian Institute of Public Health

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