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Neuroscience

D-Index
39
Citations
9344
World Ranking
8233
National Ranking
3532

Overview

John C. Gensel is a researcher affiliated with the University of Kentucky in the United States. Their academic focus is primarily situated within the field of Medicine, with a significant number of publications totaling 75 works. Their research extends into several subfields including Pathology and Forensic Medicine, Immunology, Cellular and Molecular Neuroscience, Neurology, and Public Health, Environmental and Occupational Health.

The scientist's main research topics cover a range of areas related to spinal cord injuries and immunological processes. These include:

  • Spinal Cord Injury Research
  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Nerve injury and regeneration
  • Scientific Computing and Data Management
  • Neonatal and fetal brain pathology
  • Spinal Dysraphism and Malformations

John C. Gensel has coauthored numerous papers with several frequent collaborators. Key coauthors include Andrew N. Stewart, William M. Bailey, Ethan P. Glaser, Reena Kumari, and Karim Fouad.

The researcher has published extensively in several scientific journals. Frequent publication venues include:

  • Experimental Neurology
  • Scientific Reports
  • Journal of Neurotrauma
  • Frontiers in Immunology
  • Journal of Neurosurgery Pediatrics

Some of their recent publications demonstrate a focus on immunometabolism, inflammatory responses, and cellular mechanisms following neurological injury. Selected papers include:

  • Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma, 2020, Experimental Neurology
  • Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice, 2025, Scientific Reports
  • Acute inflammatory profiles differ with sex and age after spinal cord injury, 2021, Journal of Neuroinflammation
  • Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury, 2020, Frontiers in Neurology
  • Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19, 2021, Frontiers in Immunology

Best Publications

  • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.

    Kristina A. Kigerl;John C. Gensel;Daniel P. Ankeny;Jessica K. Alexander

  • Macrophage activation and its role in repair and pathology after spinal cord injury.

    John C. Gensel;Bei Zhang

  • Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses

    Michael B. Orr;John C. Gensel

  • Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury

    Jessica L. Nielson;Jesse Paquette;Aiwen W. Liu;Cristian F. Guandique

  • Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia.

    Ashley M. Fenn;John C. Gensel;Yan Huang;Phillip G. Popovich

  • Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice

    Unknown

  • Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats.

    John C. Gensel;C. Amy Tovar;Frank P.T. Hamers;Rochelle J. Deibert

  • Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNFα-Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane

    Adam R. Ferguson;Randolph N. Christensen;John C. Gensel;Brandon A. Miller;Brandon A. Miller

  • Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma.

    Nicholas A. Devanney;Andrew N. Stewart;John C. Gensel

  • Macrophages Promote Axon Regeneration with Concurrent Neurotoxicity

    J.C. Gensel;S. Nakamura;Z. Guan;N. van Rooijen

  • IL-4 Signaling Drives a Unique Arginase+/IL-1β+ Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4Rα after Traumatic Spinal Cord Injury

    Ashley M. Fenn;Jodie C.E. Hall;John C. Gensel;Phillip G. Popovich

  • Macrophages are necessary for epimorphic regeneration in African spiny mice

    Jennifer Simkin;Thomas R Gawriluk;John C Gensel;Ashley W Seifert

  • Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration

    Caitlin E. Hill;Christoph Proschel;Mark Noble;Margot Mayer-Proschel

  • An efficient and reproducible method for quantifying macrophages in different experimental models of central nervous system pathology

    Dustin J. Donnelly;John C. Gensel;Daniel P. Ankeny;Nico van Rooijen

  • Myelin as an inflammatory mediator: Myelin interactions with complement, macrophages, and microglia in spinal cord injury.

    Timothy J. Kopper;John C. Gensel

  • Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury.

    Bei Zhang;William M. Bailey;Kaitlyn J. Braun;John C. Gensel

  • Large animal and primate models of spinal cord injury for the testing of novel therapies

    Brian K. Kwon;Femke Streijger;Caitlin E. Hill;Aileen J. Anderson

  • Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury

    Bei Zhang;William M. Bailey;Anna Leigh McVicar;John C. Gensel

  • Azithromycin drives alternative macrophage activation and improves recovery and tissue sparing in contusion spinal cord injury.

    Bei Zhang;William M. Bailey;Timothy J. Kopper;Michael B. Orr

  • SEMI-AUTOMATED SHOLL ANALYSIS FOR QUANTIFYING CHANGES IN GROWTH AND DIFFERENTIATION OF NEURONS AND GLIA

    John C. Gensel;David L. Schonberg;Jessica K. Alexander;Dana M. McTigue

  • Is neuroinflammation in the injured spinal cord different than in the brain? Examining intrinsic differences between the brain and spinal cord.

    B. Zhang;J.C. Gensel

  • Macrophages Promote Axon Regeneration with Concurrent Neurotoxicity

    Satoshi Nakamura;John C. Gensel;Zhen Guan;Nico van Rooijen

Frequent Co-Authors

Phillip G. Popovich
Phillip G. Popovich The Ohio State University
Michael S. Beattie
Michael S. Beattie University of California, San Francisco
Adam R. Ferguson
Adam R. Ferguson University of California, San Francisco
Jacqueline C. Bresnahan
Jacqueline C. Bresnahan University of California, San Francisco
Dana M. McTigue
Dana M. McTigue The Ohio State University
Paula C. Bickford
Paula C. Bickford University of South Florida
Rajiv R. Ratan
Rajiv R. Ratan Cornell University
Patrick G. Sullivan
Patrick G. Sullivan University of Kentucky
Lyn B. Jakeman
Lyn B. Jakeman National Institutes of Health
Alexander G. Rabchevsky
Alexander G. Rabchevsky University of Kentucky

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