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Gregory P. Adams

Gregory P. Adams

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
12638
World Ranking
18838
National Ranking
7696

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Antibody

His scientific interests lie mostly in Molecular biology, Antigen, Antibody, In vivo and Mutant. His research in Molecular biology intersects with topics in HER2/neu, Pancreatic cancer, Monoclonal antibody and Epidermal growth factor receptor. His Antigen research integrates issues from Amino acid and Immunotoxin.

His studies in Antibody integrate themes in fields like Cancer cell, Nanoparticle and Internalization. His work on Biodistribution as part of general In vivo research is often related to Divalent, thus linking different fields of science. His studies deal with areas such as Complementarity determining region, Affinity maturation, Alanine, Receptor–ligand kinetics and Binding site as well as Mutant.

His most cited work include:

  • Monoclonal antibody therapy of cancer (1032 citations)
  • High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. (526 citations)
  • Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site (512 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Antibody, Molecular biology, Cancer research, Antigen and Monoclonal antibody. His Antibody study is associated with Immunology. His work carried out in the field of Molecular biology brings together such families of science as In vivo, In vitro, Biodistribution, Biochemistry and Phage display.

His Cancer research study combines topics from a wide range of disciplines, such as Cancer cell, Cancer, Epidermal growth factor receptor, Secretion and Pathology. His Antigen study incorporates themes from Radioimmunotherapy, Immunotoxin, Mutant and Recombinant DNA. His study on Monoclonal antibody also encompasses disciplines like

  • Cytotoxic T cell which connect with Mechanism of action,
  • Virology together with Ratón.

He most often published in these fields:

  • Antibody (46.79%)
  • Molecular biology (36.70%)
  • Cancer research (26.61%)

What were the highlights of his more recent work (between 2013-2020)?

  • Antibody (46.79%)
  • Cancer research (26.61%)
  • Receptor (12.84%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Antibody, Cancer research, Receptor, Biophysics and Ribosome-inactivating protein. The various areas that Gregory P. Adams examines in his Antibody study include Biochemistry, Flow cytometry and Antigen. His research integrates issues of Cancer cell, Immunogenic cell death, Cytotoxic T cell, Epithelial cell adhesion molecule and Bone morphogenetic protein in his study of Cancer research.

His Receptor research includes elements of Prostate, Chimera, Apoptosis, Fallopian tube and Lung. His work investigates the relationship between Biophysics and topics such as Molecular imaging that intersect with problems in Molecular biology, Receptor expression, Tumor antigen and Binding site. The study incorporates disciplines such as Cancer stem cell, Antibody-drug conjugate, Drug resistance and In vivo in addition to Trastuzumab.

Between 2013 and 2020, his most popular works were:

  • Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance. (12 citations)
  • Molecular Simulation of Receptor Occupancy and Tumor Penetration of an Antibody and Smaller Scaffolds: Application to Molecular Imaging. (11 citations)
  • CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies (5 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Antibody

Gregory P. Adams mostly deals with Cancer research, Antibody, Ovarian cancer, Cancer cell and Immunotherapy. His biological study spans a wide range of topics, including Mechanism of action and Efflux, Biochemistry, Small molecule, Protein biosynthesis. His Antibody research includes themes of Biophysics, Tumor penetration, Molecular biology, Fusion protein and Cytotoxic T cell.

His study focuses on the intersection of Ovarian cancer and fields such as Endometrial cancer with connections in the field of Receptor. His Receptor study integrates concerns from other disciplines, such as Molecular imaging, Tumor antigen and Binding site. The concepts of his Cancer cell study are interwoven with issues in Ovarian tumor, Human leukocyte antigen and Flow cytometry, Immunology.

Best Publications

  • Monoclonal antibody therapy of cancer

    Gregory P Adams;Louis M Weiner

  • High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.

    Gregory P. Adams;Robert Schier;Adrian M. McCall;Heidi H. Simmons

  • Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

    Robert Schier;Adrian McCall;Gregory P. Adams;Keith W. Marshall

  • Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv using affinity-driven selection.

    Robert Schier;Jacqueline Bye;Gerald Apell;Adrian McCall

  • Affinity and avidity in antibody-based tumor targeting.

    Stephen I. Rudnick;Gregory P. Adams

  • Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging.

    Lily Yang;Hui Mao;Y. Andrew Wang;Zehong Cao

  • Highly Specific in Vivo Tumor Targeting by Monovalent and Divalent Forms of 741F8 Anti-c-erbB-2 Single-Chain Fv

    Gregory P. Adams;John E. McCartney;Mei-Sheng Tai;Hermann Oppermann

  • Increased Affinity Leads to Improved Selective Tumor Delivery of Single-Chain Fv Antibodies

    Gregory P. Adams;Robert Schier;Keith Marshall;Ellen J. Wolf

  • Monoclonal antibody therapy for cancer.

    Margaret von Mehren;Gregory P. Adams;Louis M. Weiner

  • Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

    Stephen I. Rudnick;Jianlong Lou;Calvin C. Shaller;Yong Tang

  • Selection and characterization of HER2/neu-binding affibody ligands.

    Maria Wikman;Ann-Charlott Steffen;Elin Gunneriusson;Vladimir Tolmachev

  • T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity

    Markus Chmielewski;Andreas Hombach;Claudia Heuser;Gregory P. Adams

  • Expression of Mutated Epidermal Growth Factor Receptor by Non-Small Cell Lung Carcinomas

    I. E. Garcia De Palazzo;G. P. Adams;Padma Sundareshan;A. J. Wong

  • Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer.

    Susan J. Knox;Michael L. Goris;Margaret Tempero;Paul L. Weiden

  • Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu.

    GP Adams;R Schier;AM McCall;RS Crawford

  • Generating improved single-chain Fv molecules for tumor targeting

    Gregory P Adams;Robert Schier

  • In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library.

    R Schier;J D Marks;J D Marks;E J Wolf;G Apell

  • Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro.

    M K Robinson;K M Hodge;E Horak;Å L Sundberg

  • Bispecific single chain FV antibody molecules and methods of use thereof

    Gregory P. Adams;Eva M. Horak;Louis M. Weiner;James D. Marks

  • Quantitative Immuno-Positron Emission Tomography Imaging of HER2-Positive Tumor Xenografts with an Iodine-124 Labeled Anti-HER2 Diabody

    Matthew K. Robinson;Mohan Doss;Calvin Shaller;Deepa Narayanan

Frequent Co-Authors

Louis M. Weiner
Louis M. Weiner Georgetown University Medical Center
James D. Marks
James D. Marks University of California, San Francisco
Walter F. Stafford
Walter F. Stafford Harvard University
Roland L. Dunbrack
Roland L. Dunbrack Fox Chase Cancer Center
Stefan Ståhl
Stefan Ståhl Royal Institute of Technology
Wan Y. Shih
Wan Y. Shih Drexel University
Andrew M. Scott
Andrew M. Scott La Trobe University
Wei-Heng Shih
Wei-Heng Shih Drexel University
Vladimir Tolmachev
Vladimir Tolmachev Uppsala University
Anna M. Wu
Anna M. Wu City Of Hope National Medical Center

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