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Gertrude B. Elion

Gertrude B. Elion

D-Index & Metrics

Chemistry

D-Index
69
Citations
20475
World Ranking
6109
National Ranking
1859

Biology and Biochemistry

D-Index
70
Citations
21526
World Ranking
6915
National Ranking
3190

Research.com Recognitions

  • 1999 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1991 - US President's National Medal of Science "For her basic research which enhanced the sciences of chemistry and medicine by elucidating fundamental principles of drug-receptor interactions for nucleic acid antagonists.", Presented by President Bush at a White House Rose Garden Ceremony on September 16, 1991.
  • 1991 - Member of the National Academy of Medicine (NAM)
  • 1990 - Member of the National Academy of Sciences
  • 1988 - Nobel Prize for their discoveries of important principles for drug treatment
  • 1968 - Garvan–Olin Medal, American Chemical Society (ACS)

Overview

Gertrude B. Elion was affiliated with Duke University in the United States during their scientific career. Their research primarily focused on the field of Medicine, specifically within the subfield of Oncology.

The scientist's work concentrated on topics related to viral-associated cancers and disorders, an area prominently featured in their publications.

The recorded publication includes the paper titled "Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication," published in 2020 in UNC Libraries. This paper investigates the impact of antiviral treatment on viral DNA replication processes.

Frequent co-authors throughout their career included:

  • Brenda M. Colby
  • James S. Shaw
  • Joseph S. Pagano

Their published work appeared in venues such as:

  • UNC Libraries

Throughout their career, multiple honors were awarded to Gertrude B. Elion, including:

  • Nobel Prize (1988) for discoveries of important principles for drug treatment
  • Member of the National Academy of Sciences (1990)
  • Member of the National Academy of Medicine (1991)
  • US President's National Medal of Science (1991), awarded for basic research elucidating fundamental principles of drug-receptor interactions for nucleic acid antagonists, presented by President Bush
  • Fellow of the American Association for the Advancement of Science (1999)
  • Garvan-Olin Medal from the American Chemical Society (1968)

Best Publications

  • Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

    Gertrude B. Elion;Phillip A. Furman;James A. Fyfe;Paulo de Miranda

  • 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

    H. J. Schaeffer;Lilia Beauchamp;P. de Miranda;Gertrude B. Elion

  • The purine path to chemotherapy

    Gertrude B. Elion

  • Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

    J A Fyfe;P M Keller;P A Furman;R L Miller

  • Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.

    Gertrude B. Elion;Samuel Singer;George H. Hitchings

  • On the Mechanism of Inactivation of Xanthine Oxidase by Allopurinol and Other Pyrazolo[3,4-d]pyrimidines

    Vincent Massey;Hirochika Komai;Graham Palmer;Gertrude B. Elion

  • A comparison of the specificities of xanthine oxidase and aldehyde oxidase.

    Thomas A. Krenitsky;Shannon M. Neil;Gertrude B. Elion;George H. Hitchings

  • Mechanism of action and selectivity of acyclovir.

    Gertrude B. Elion

  • Metabolic studies of allopurinol, an inhibitor of xanthine oxidase

    Gertrude B. Elion;Aylene Kovensky;George H. Hitchings

  • Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase

    Gertrude B. Elion;Sandra Callahan;Henry Nathan;Samuel Bieber

  • Studies on Condensed Pyrimidine Systems. IX. The Synthesis of Some 6-Substituted Purines

    Gertrude B. Elion;Elizabeth Burgi;George H. Hitchings

  • Antagonists of nucleic acid derivatives. VII. 2, 4-Diaminopyrimidines.

    George H. Hitchings;Elvira A. Falco;Henry Vanderwerff;Peter B. Russell

  • Human hypoxanthine phosphoribosyltransferase. I. Purification, properties, and specificity.

    Thomas A. Krenitsky;Rhoda Papaioannou;Gertrude B. Elion

  • The biochemistry and mechanism of action of acyclovir.

    Gertrude B. Elion

  • Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity.

    T A Krenitsky;J V Tuttle;G W Koszalka;I S Chen

  • Renal clearance of oxipurinol, the chief metabolite of allopurinol

    Gertrude B. Elion;Ts'ai-Fan Yü;Alexander B. Gutman;George H. Hitchings

  • Acyclovir: Discovery, mechanism of action, and selectivity

    Elion Gb

  • Effect of Acycloguanosine Treatment on Acute and Latent Herpes Simplex Infections in Mice

    Hugh J. Field;Susanne E. Bell;Gertrude B. Elion;Anthony A. Nash

  • Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity.

    R.L. Miller;D.L. Adamczyk;W.H. Miller;G.W. Koszalka

  • Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate

    Unknown

  • Nobel lecture in physiology or medicine--1988. The purine path to chemotherapy.

    Gertrude B. Elion

Frequent Co-Authors

George H. Hitchings
George H. Hitchings York University
Darell D. Bigner
Darell D. Bigner Duke University
Henry S. Friedman
Henry S. Friedman Duke University
Owen W. Griffith
Owen W. Griffith Medical College of Wisconsin
Mark W. Dewhirst
Mark W. Dewhirst Duke University
Joanne Kurtzberg
Joanne Kurtzberg Duke University
Peter J. Houghton
Peter J. Houghton The University of Texas Health Science Center at San Antonio
Daniel T. Laskowitz
Daniel T. Laskowitz Duke University
Glenn Dranoff
Glenn Dranoff Harvard Medical School
Francis Ali-Osman
Francis Ali-Osman Duke University

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