Takeshi Nishino

Best Publications

• Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

  C. Enroth;B.T. Eger;K. Okamoto;T. Nishino

  893
  Citations

• Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase.

  Russ Hille;Takeshi Nishino

  609
  Citations

• An Extremely Potent Inhibitor of Xanthine Oxidoreductase CRYSTAL STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX AND MECHANISM OF INHIBITION

  Ken Okamoto;Bryan T. Eger;Tomoko Nishino;Shiro Kondo

  532
  Citations

• Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase.

  Tomoko Nishino;Ken Okamoto;Bryan T. Eger;Emil F. Pai

  457
  Citations

• The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition

  Ken Okamoto;Koji Matsumoto;Russ Hille;Bryan T. Eger

  340
  Citations

• Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product

  Shoko Hirotsu;Yasuko Abe;Kengo Okada;Noriyuki Nagahara

  334
  Citations

• Aureusidin Synthase: A Polyphenol Oxidase Homolog Responsible for Flower Coloration

  T. Nakayama;K. Yonekura-Sakakibara;T. Sato;S. Kikuchi

  293
  Citations

• The Conversion of Xanthine Dehydrogenase to Xanthine Oxidase and the Role of the Enzyme in Reperfusion Injury

  Takeshi Nishino

  285
  Citations

• Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis.

  Noriyuki Nagahara;Takaaki Ito;Hitoshi Kitamura;Takeshi Nishino

  280
  Citations

• Molybdenum enzymes in higher organisms

  Russ Hille;Takeshi Nishino;Takeshi Nishino;Florian Bittner

  268
  Citations

• Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mutagenesis.

  Noriyuki Nagahara;Taro Okazaki;Takeshi Nishino

  216
  Citations

• Cys2/His2 zinc-finger protein family of petunia: Evolution and general mechanism of target-sequence recognition

  Ken-ichi Kubo;Ayako Sakamoto;Akira Kobayashi;Zbigniew Rybka

  207
  Citations

• Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.

  Tomoko Nishino;Ken Okamoto;Yuko Kawaguchi;Hiroyuki Hori

  202
  Citations

• Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene.

  Ichida K;Amaya Y;Noda K;Minoshima S

  193
  Citations

• Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria.

  Kimiyoshi Ichida;Yoshihiro Amaya;Naoyuki Kamatani;Takeshi Nishino

  175
  Citations

• Mutation of Human Molybdenum Cofactor Sulfurase Gene Is Responsible for Classical Xanthinuria Type II

  Kimiyoshi Ichida;Tomohiro Matsumura;Ryouzo Sakuma;Tatsuo Hosoya

  170
  Citations

• Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate.

  Yuichiro Yamaguchi;Tomohiro Matsumura;Kimiyoshi Ichida;Ken Okamoto

  169
  Citations

• Archaebacterial ether-linked lipid biosynthetic gene. Expression cloning, sequencing, and characterization of geranylgeranyl-diphosphate synthase.

  Shin-Ichi Ohnuma;Manabu Suzuki;Tokuzo Nishino

  162
  Citations

• FYX-051: A Novel and Potent Hybrid-Type Inhibitor of Xanthine Oxidoreductase

  Koji Matsumoto;Ken Okamoto;Naoki Ashizawa;Takeshi Nishino

  158
  Citations

• Y-700 (1-(3-Cyano-4-(2,2-dimethylpropoxy)phenyl)-1H- pyrazole-4-carboxylic Acid): A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion

  Atsushi Fukunari;Ken Okamoto;Takeshi Nishino;Bryan T Eger

  149
  Citations

• Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.

  Ken Okamoto;Bryan T Eger;Tomoko Nishino;Emil F Pai

  146
  Citations

• Differences in redox and kinetic properties between NAD-dependent and O2-dependent types of rat liver xanthine dehydrogenase.

  T Saito;T Nishino

  135
  Citations

• The Conversion from the Dehydrogenase Type to the Oxidase Type of Rat Liver Xanthine Dehydrogenase by Modification of Cysteine Residues with Fluorodinitrobenzene

  Tomoko Nishino;Tomoko Nishino;Takeshi Nishino

  128
  Citations