Takeshi Nishino

Takeshi Nishino publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Takeshi Nishino sits on this spectrum.

Takeshi Nishino D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Takeshi Nishino sits on this spectrum.

Best Publications

• Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

  C. Enroth;B.T. Eger;K. Okamoto;T. Nishino

  893
  Citations

• Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase.

  Russ Hille;Takeshi Nishino

  609
  Citations

• An Extremely Potent Inhibitor of Xanthine Oxidoreductase CRYSTAL STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX AND MECHANISM OF INHIBITION

  Ken Okamoto;Bryan T. Eger;Tomoko Nishino;Shiro Kondo

  532
  Citations

• Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase.

  Tomoko Nishino;Ken Okamoto;Bryan T. Eger;Emil F. Pai

  457
  Citations

• The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition

  Ken Okamoto;Koji Matsumoto;Russ Hille;Bryan T. Eger

  340
  Citations

• Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product

  Shoko Hirotsu;Yasuko Abe;Kengo Okada;Noriyuki Nagahara

  334
  Citations

• Aureusidin Synthase: A Polyphenol Oxidase Homolog Responsible for Flower Coloration

  T. Nakayama;K. Yonekura-Sakakibara;T. Sato;S. Kikuchi

  293
  Citations

• The Conversion of Xanthine Dehydrogenase to Xanthine Oxidase and the Role of the Enzyme in Reperfusion Injury

  Takeshi Nishino

  285
  Citations

• Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis.

  Noriyuki Nagahara;Takaaki Ito;Hitoshi Kitamura;Takeshi Nishino

  280
  Citations

• Molybdenum enzymes in higher organisms

  Russ Hille;Takeshi Nishino;Takeshi Nishino;Florian Bittner

  268
  Citations

• Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mutagenesis.

  Noriyuki Nagahara;Taro Okazaki;Takeshi Nishino

  216
  Citations

• Cys2/His2 zinc-finger protein family of petunia: Evolution and general mechanism of target-sequence recognition

  Ken-ichi Kubo;Ayako Sakamoto;Akira Kobayashi;Zbigniew Rybka

  207
  Citations

• Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.

  Tomoko Nishino;Ken Okamoto;Yuko Kawaguchi;Hiroyuki Hori

  202
  Citations

• Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene.

  Ichida K;Amaya Y;Noda K;Minoshima S

  193
  Citations

• Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria.

  Kimiyoshi Ichida;Yoshihiro Amaya;Naoyuki Kamatani;Takeshi Nishino

  175
  Citations

• Mutation of Human Molybdenum Cofactor Sulfurase Gene Is Responsible for Classical Xanthinuria Type II

  Kimiyoshi Ichida;Tomohiro Matsumura;Ryouzo Sakuma;Tatsuo Hosoya

  170
  Citations

• Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate.

  Yuichiro Yamaguchi;Tomohiro Matsumura;Kimiyoshi Ichida;Ken Okamoto

  169
  Citations

• Archaebacterial ether-linked lipid biosynthetic gene. Expression cloning, sequencing, and characterization of geranylgeranyl-diphosphate synthase.

  Shin-Ichi Ohnuma;Manabu Suzuki;Tokuzo Nishino

  162
  Citations

• FYX-051: A Novel and Potent Hybrid-Type Inhibitor of Xanthine Oxidoreductase

  Koji Matsumoto;Ken Okamoto;Naoki Ashizawa;Takeshi Nishino

  158
  Citations

• Y-700 (1-(3-Cyano-4-(2,2-dimethylpropoxy)phenyl)-1H- pyrazole-4-carboxylic Acid): A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion

  Atsushi Fukunari;Ken Okamoto;Takeshi Nishino;Bryan T Eger

  149
  Citations

• Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.

  Ken Okamoto;Bryan T Eger;Tomoko Nishino;Emil F Pai

  146
  Citations

• Differences in redox and kinetic properties between NAD-dependent and O2-dependent types of rat liver xanthine dehydrogenase.

  T Saito;T Nishino

  135
  Citations

• The Conversion from the Dehydrogenase Type to the Oxidase Type of Rat Liver Xanthine Dehydrogenase by Modification of Cysteine Residues with Fluorodinitrobenzene

  Tomoko Nishino;Tomoko Nishino;Takeshi Nishino

  128
  Citations