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Biology and Biochemistry

D-Index
60
Citations
9865
World Ranking
12199
National Ranking
224

Overview

Georges Vauquelin is affiliated with the Vrije Universiteit Brussel in Belgium. Their research focus lies at the intersection of biochemistry, genetics, molecular biology, and medicine, with a strong emphasis on molecular biology. The work contributes to specialized subfields including radiology, nuclear medicine and imaging, computational theory and mathematics, epidemiology, and oncology.

The central topics of Vauquelin's research encompass receptor mechanisms and signaling, monoclonal and polyclonal antibodies research, protein structure and dynamics, computational drug discovery methods, neuroendocrine tumor research advances, lung cancer research studies, and radiopharmaceutical chemistry and applications.

Vauquelin has published in various venues relevant to pharmacology and biochemical research. These frequent publication venues include:

  • Pharmaceuticals
  • Pharmacology Research & Perspectives
  • Trends in Pharmacological Sciences
  • Fundamental and Clinical Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent scholarly output shows a focus on receptor binding mechanisms and pharmacological kinetics. Notable papers include:

  • "Distinct In Vitro Binding Profile of the Somatostatin Receptor Subtype 2 Antagonist [177Lu]Lu-OPS201 Compared to the Agonist [177Lu]Lu-DOTA-TATE," 2021, Pharmaceuticals
  • "Induced fit versus conformational selection: From rate constants to fluxes... and back to rate constants," 2021, Pharmacology Research & Perspectives
  • "Fluxes for Unraveling Complex Binding Mechanisms," 2020, Trends in Pharmacological Sciences
  • "Competition in drug binding and... the race to equilibrium," 2022, Fundamental and Clinical Pharmacology
  • "Competition between induced fit- and conformational selection binding: how different flux-based approaches help clarifying their interplay," 2023, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in Vauquelin's research include Dominique Maes, Rosalba Mansi, Pascale Plas, Melpomeni Fani, and David C. Swinney. This network reflects interdisciplinary engagement across pharmacology, biochemistry, and imaging sciences.

Best Publications

  • Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action

    Georges Vauquelin;Steven J Charlton

  • Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

    Georges Vauquelin;Steven J Charlton

  • Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors.

    P M L Vanderheyden;F L P Fierens;J P De Backer;N Fraeyman

  • Imidazoline receptors, non-adrenergic idazoxan binding sites and alpha 2-adrenoceptors in the human central nervous system.

    H. De Vos;G. Bricca;J. De Keyser;J.-P. De Backer

  • Age-related changes in the human nigrostriatal dopaminergic system.

    Jacques De Keyser;Guy Ebinger;Georges Vauquelin

  • Characterization with [3H] dihydroergocryptine of the alpha-adrenergic receptor of the hepatic plasma membrane. Comparison with the beta-adrenergic receptor in normal and adrenalectomized rats.

    G Guellaen;M Yates-Aggerbeck;G Vauquelin;D Strosberg

  • Autoradiographic localization of D1 and D2 dopamine receptors in the human brain.

    Jacques De Keyser;Antoon Claeys;Jean-Paul De Backer;Guy Ebinger

  • Autoradiographic distribution of D3-type dopamine receptors in human brain using [3H]7-hydroxy-N,N-di-n-propyl-2-aminotetralin

    L. Herroelen;J.-P. De Backer;N. Wilczak;A. Flamez

  • Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography.

    G Vauquelin;P Geynet;J Hanoune;A D Strosberg

  • Slow antagonist dissociation and long-lasting in vivo receptor protection

    Georges Vauquelin;Isabelle Van Liefde

  • Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding.

    Frederik L.P Fierens;Patrick M.L Vanderheyden;Jean-Paul De Backer;Georges Vauquelin

  • The effect of aging on the D1 dopamine receptors in human frontal cortex.

    Jacques de Keyser;Jean-Paul De Backer;Georges Vauquelin;Guy Ebinger

  • Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays

    Steven J Charlton;Georges Vauquelin

  • Involvement of insulin-regulated aminopeptidase in the effects of the renin–angiotensin fragment angiotensin IV: a review

    Bart Stragier;Dimitri De Bundel;Sophie Sarre;Ilse Smolders

  • Effects of target binding kinetics on in vivo drug efficacy: koff , kon and rebinding.

    Georges Vauquelin

  • Evidence for essential disulfide bonds in beta1-adrenergic receptors of turkey erythrocyte membranes. Inactivation by dithiothreitol.

    Georges Vauquelin;Serge P. Bottari;Louis L. Kanarek;Arthur Strosberg

  • Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats : Unexploited antidepressive (lead) products

    J A Hasrat;T De Bruyne;J P De Backer;G Vauquelin

  • G protein-coupled receptors: a count of 1001 conformations.

    G. Vauquelin;I. Van Liefde

  • Angiotensin IV is a potent agonist for constitutive active human AT1 receptors. Distinct roles of the N-and C-terminal residues of angiotensin II during AT1 receptor activation

    Minh Tam Le;Patrick M.L. Vanderheyden;Márta Szaszák;László Hunyady

  • Sartan-AT1 receptor interactions: in vitro evidence for insurmountable antagonism and inverse agonism.

    I. Van Liefde;G. Vauquelin

Frequent Co-Authors

Yvette Michotte
Yvette Michotte Vrije Universiteit Brussel
Dirk Tourwé
Dirk Tourwé Vrije Universiteit Brussel
Arthur Donny Strosberg
Arthur Donny Strosberg Scripps Research Institute
Ilse Smolders
Ilse Smolders Vrije Universiteit Brussel
László Hunyady
László Hunyady Semmelweis University
Luc Pieters
Luc Pieters University of Antwerp
Jacques Hanoune
Jacques Hanoune Grenoble Alpes University
Arnold J. Vlietinck
Arnold J. Vlietinck University of Antwerp
Géza Tóth
Géza Tóth University of the Basque Country
Siew Yeen Chai
Siew Yeen Chai Monash University

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