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Siew Yeen Chai

Siew Yeen Chai

D-Index & Metrics

Neuroscience

D-Index
56
Citations
9114
World Ranking
4595
National Ranking
128

Overview

Siew Yeen Chai is affiliated with Monash University in Australia, with a research focus primarily in the field of Medicine. Their scholarly work encompasses several subfields including Endocrinology, Diabetes and Metabolism, Oncology, Cellular and Molecular Neuroscience, Cardiology and Cardiovascular Medicine, and Neurology.

The scientist's main research topics cover a broad range of biomedical and physiological areas. These include Diabetes Treatment and Management, Peptidase Inhibition and Analysis, Neuropeptides and Animal Physiology, Neuroinflammation and Neurodegeneration Mechanisms, Pancreatic Function and Diabetes, Birth, Development, and Health, as well as Pregnancy and Preeclampsia Studies.

Publications by Siew Yeen Chai have appeared in several scientific venues with notable frequency. The most frequent publication venues include:

  • International Journal of Cardiology
  • Frontiers in Molecular Biosciences
  • Scientific Reports
  • Nature Communications
  • RSC Medicinal Chemistry

Among the recent papers published, the following are representative examples:

  • "Transcriptional signature in microglia associated with Aβ plaque phagocytosis," 2021, Nature Communications
  • "Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP)," 2020, RSC Medicinal Chemistry
  • "Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats," 2020, Frontiers in Molecular Biosciences
  • "Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke," 2023, Scientific Reports
  • "Is There an Interplay Between the Functional Domains of IRAP?," 2020, Frontiers in Cell and Developmental Biology

Collaboration is a significant aspect of their research activities. Frequent co-authors include:

  • Stefan L.S. Kwa
  • Z.F. Tan
  • Z.Y. Lian
  • Joe J. Hoo
  • C.Z.F. Chua

The breadth of Siew Yeen Chai's work reflects an interdisciplinary approach within medicine, spanning molecular mechanisms to clinical relevance in areas such as diabetes and cardiovascular health. Their research into insulin-regulated aminopeptidase (IRAP) inhibition connects biochemical studies with potential therapeutic applications, observed through the representation of their contributions in both biochemical and clinical research journals.

Best Publications

  • The brain renin-angiotensin system: location and physiological roles

    Michael J McKinley;Anthony L Albiston;Andrew M Allen;M L Mathai

  • Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase

    Anthony L. Albiston;Sharon G. McDowall;Duana Matsacos;Pamela Sim

  • Transcriptional signature in microglia associated with Aβ plaque phagocytosis.

    Alexandra Grubman;Alexandra Grubman;Alexandra Grubman;Xin Yi Choo;Gabriel Chew;John F Ouyang

  • The angiotensin IV/AT4 receptor.

    S. Y. Chai;R. Fernando;G. Peck;S.-Y. Ye

  • Angiotensin receptors in the nervous system.

    A.M. Allen;I. Moeller;T.A. Jenkins;J. Zhuo

  • Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP).

    Rebecca A. Lew;Tomris Mustafa;Siying Ye;Sharon G. McDowall

  • Angiotensin converting enzyme in rat brain visualized by quantitative in vitro autoradiography.

    Siew Yeen Chai;F.A.O. Mendelsohn;G. Paxinos

  • Mapping tissue angiotensin-converting enzyme and angiotensin AT1, AT2 and AT4 receptors.

    Jialong Zhuo;Ingrid Moeller;Trisha Jenkins;Siew Yeen Chai

  • Cholecystokinin and tyrosine hydroxylase messenger RNAs in neurons of rat mesencephalon: peptide/monoamine coexistence studies using in situ hybridization combined with immunocytochemistry.

    K. Seroogy;M. Schalling;S. Brené;Å. Dagerlind

  • The globin fragment LVV-hemorphin-7 is an endogenous ligand for the AT4 receptor in the brain.

    Ingrid Moeller;Rebecca A. Lew;Frederick A. O. Mendelsohn;A. Ian Smith

  • Localization and characterization of angiotensin II receptor binding and angiotensin converting enzyme in the human medulla oblongata.

    Andrew M. Allen;Siew Yeen Chai;Jenni Clevers;Michael J. McKinley

  • Localization of endothelin receptors in rat kidney.

    M Kohzuki;Colin I Johnston;Syn Y Chai;David J Casley

  • The angiotensin converting enzyme (ACE) inhibitor, perindopril, modifies the clinical features of Parkinson's disease

    K A Reardon;F A O Mendelsohn;Siew Y Chai;Malcolm K Horne

  • Potentiation of cholinergic transmission in the rat hippocampus by angiotensin IV and LVV-hemorphin-7.

    Joohyung Lee;Siew Yeen Chai;Frederick A O Mendelsohn;Margaret J. Morris

  • Angiotensin II receptor binding associated with nigrostriatal dopaminergic neurons in human basal ganglia.

    Andrew M. Allen;Duncan P. MacGregor;Siew Y. Chai;Geoffrey A. Donnan

  • Localization and characterization of endothelin receptor binding sites in the rat brain visualized by in vitro autoradiography.

    M Kohzuki;Syn Y Chai;G Paxinos;A Karavas

  • Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase.

    Anthony L Albiston;Craig J Morton;Hooi Ling Ng;Vi Pham

  • Distribution of angiotensin IV binding sites (AT4 receptor) in the human forebrain, midbrain and pons as visualised by in vitro receptor autoradiography.

    Siew Yeen Chai;Maria A. Bastias;Eleanor F. Clune;Duana J. Matsacos

  • Angiotensin-Converting Enzyme Modulates Dopamine Turnover in the Striatum

    Trisha A. Jenkins;Frederick A. O. Mendelsohn;Siew Yeen Chai

  • The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus--potential role in modulation of glucose uptake in neurones?

    Ruani N. Fernando;Anthony L. Albiston;Siew Y. Chai

  • Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase.

    Grantley R. Peck;Siying Ye;Vi Pham;Ruani N. Fernando

Frequent Co-Authors

Frederick A.O. Mendelsohn
Frederick A.O. Mendelsohn University of Melbourne
Ilse Smolders
Ilse Smolders Vrije Universiteit Brussel
Andrew M. Allen
Andrew M. Allen University of Melbourne
George Paxinos
George Paxinos Neuroscience Research Australia
Yvette Michotte
Yvette Michotte Vrije Universiteit Brussel
Ryan Lister
Ryan Lister University of Western Australia
Brian J. Oldfield
Brian J. Oldfield Monash University
Stéphane Auvin
Stéphane Auvin Université Paris Cité

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