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Biology and Biochemistry

D-Index
48
Citations
14865
World Ranking
18207
National Ranking
347

Overview

Dirk Fasshauer is affiliated with the University of Lausanne in Switzerland and specializes in studies primarily within the field of Biochemistry, Genetics and Molecular Biology. Their research portfolio includes significant contributions in various subfields such as Cell Biology, Molecular Biology, Paleontology, Cellular and Molecular Neuroscience, and Epidemiology.

The scientist's work addresses numerous topics, reflecting a broad interest in biological processes at the cellular and molecular levels. Key topics include:

  • Cellular transport and secretion
  • Lipid Membrane Structure and Behavior
  • Marine Invertebrate Physiology and Ecology
  • Endoplasmic Reticulum Stress and Disease
  • Photoreceptor and optogenetics research
  • Physiological and biochemical adaptations
  • Protist diversity and phylogeny

Fasshauer has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Proceedings of the National Academy of Sciences, Protein Science, and Scientific Reports, demonstrating a consistent presence in both preprint repositories and peer-reviewed journals.

Their recent papers include:

  • "The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission" (2020) published in Scientific Reports
  • "Glycine as a signaling molecule and chemoattractant in Trichoplax (Placozoa): insights into the early evolution of neurotransmitters" (2020) published in Neuroreport
  • "Hidden cell diversity in Placozoa: ultrastructural insights from Hoilungia hongkongensis" (2021) published in Cell and Tissue Research
  • "Prototypic SNARE Proteins Are Encoded in the Genomes of Heimdallarchaeota, Potentially Bridging the Gap between the Prokaryotes and Eukaryotes" (2020) published in Current Biology
  • "Choanoflagellates and the ancestry of neurosecretory vesicles" (2021) published in Philosophical Transactions of the Royal Society B Biological Sciences

In their collaborative work, Fasshauer frequently partners with several co-authors, notably Frédérique Varoqueaux, Émilie Neveu, Leonid L. Moroz, Daria Y. Romanova, and Dany Khalifeh. These collaborations underline a network of researchers focused on molecular and cellular biology topics.

Best Publications

  • Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

    Sutton Rb;Fasshauer D;Jahn R;Brunger At

  • Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

    D Fasshauer;R B Sutton;A T Brunger;R Jahn

  • Molecular machines governing exocytosis of synaptic vesicles

    Reinhard Jahn;Dirk Fasshauer

  • Structural Changes Are Associated with Soluble N-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation

    Dirk Fasshauer;Dirk Fasshauer;Henning Otto;Henning Otto;William K. Eliason;William K. Eliason;Reinhard Jahn;Reinhard Jahn

  • N- to C-terminal SNARE complex assembly promotes rapid membrane fusion

    Ajaybabu V. Pobbati;Alexander Stein;Dirk Fasshauer

  • Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs

    Wolfram Antonin;Dirk Fasshauer;Stefan Becker;Reinhard Jahn

  • Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties.

    Dirk Fasshauer;Wolfram Antonin;Martin Margittai;Stefan Pabst

  • Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1.

    M. Margittai;Jerker Widengren;E. Schweinberger;G. F. Schroder

  • Kinetics of Synaptotagmin Responses to Ca2+ and Assembly with the Core SNARE Complex onto Membranes

    Anson F Davis;Jihong Bai;Dirk Fasshauer;Mark J Wolowick

  • Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles

    Jakob B Sørensen;Katrin Wiederhold;Emil M Müller;Ira Milosevic

  • A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function.

    Wolfram Antonin;Claudia Holroyd;Dirk Fasshauer;Stefan Pabst

  • Identification of a Minimal Core of the Synaptic SNARE Complex Sufficient for Reversible Assembly and Disassembly

    Dirk Fasshauer;William K. Eliason;and Axel T. Brünger;Reinhard Jahn

  • Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide.

    Pawel Burkhardt;Douglas A Hattendorf;William I Weis;Dirk Fasshauer

  • Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

    Alf Honigmann;Geert van den Bogaart;Geert van den Bogaart;Emilio Iraheta;H Jelger Risselada

  • A Structural Change Occurs upon Binding of Syntaxin to SNAP-25 *

    Dirk Fasshauer;Dieter Bruns;Betty Shen;Reinhard Jahn;Reinhard Jahn

  • An Elaborate Classification of SNARE Proteins Sheds Light on the Conservation of the Eukaryotic Endomembrane System

    Tobias H. Kloepper;C. Nickias Kienle;Dirk Fasshauer

  • A Transient N-terminal Interaction of SNAP-25 and Syntaxin Nucleates SNARE Assembly

    Dirk Fasshauer;Martin Margittai

  • Novel Cell Types, Neurosecretory Cells, and Body Plan of the Early-Diverging Metazoan Trichoplax adhaerens

    Carolyn L. Smith;Frédérique Varoqueaux;Frédérique Varoqueaux;Maike Kittelmann;Rita N. Azzam

  • Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis

    Tobias H Klöpper;Nickias Kienle;Dirk Fasshauer;Sean Munro

  • Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs (membrane fusionyneurotransmissionyclostridial neurotoxins)

    Dirk Fasshauer;R. Bryan Sutton;A Xel T. Brunger;Reinhard Jahn

Frequent Co-Authors

Reinhard Jahn
Reinhard Jahn Max Planck Society
Leonid L. Moroz
Leonid L. Moroz University of Florida
Axel T. Brunger
Axel T. Brunger Stanford University
Markus C. Wahl
Markus C. Wahl Freie Universität Berlin
Helmut Grubmüller
Helmut Grubmüller Max Planck Society
Ralf Langen
Ralf Langen University of Southern California
Ralf Ficner
Ralf Ficner University of Göttingen
Bernd Schierwater
Bernd Schierwater University of Veterinary Medicine Hannover, Foundation
Kent L. McDonald
Kent L. McDonald University of California, Berkeley
Stefan W. Hell
Stefan W. Hell Max Planck Society

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