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Christopher E. Dempsey

Christopher E. Dempsey

D-Index & Metrics

Chemistry

D-Index
42
Citations
7571
World Ranking
17447
National Ranking
953

Overview

Christopher E. Dempsey is affiliated with the University of Bristol in the United Kingdom. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with significant contributions to cardiology and cardiovascular medicine, molecular biology, and cellular and molecular neuroscience.

The main topics of their work include:

  • Cardiac electrophysiology and arrhythmias
  • Ion channel regulation and function
  • Receptor mechanisms and signaling
  • Neuroscience and neural engineering
  • Neuroscience and neuropharmacology research
  • ECG monitoring and analysis
  • Cardiomyopathy and myosin studies

Their recent papers include:

  • "An Update on the Structure of hERG," 2020, Frontiers in Pharmacology
  • "Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant," 2021, Cellular and Molecular Life Sciences
  • "Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome," 2023, Philosophical Transactions of the Royal Society B Biological Sciences
  • "Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue," 2023, Pharmaceuticals
  • "Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment," 2020, Biochemical and Biophysical Research Communications

Frequent co-authors in Dempsey's research include:

  • Yihong Zhang
  • Jules C. Hancox
  • Stephen C. Harmer
  • Andrew S. Butler
  • Ehab Al-Moubarak

The scientist's work has been published in journals such as:

  • Frontiers in Pharmacology
  • Cellular and Molecular Life Sciences
  • Physiological Reports
  • Philosophical Transactions of the Royal Society B Biological Sciences
  • Pharmaceuticals

Best Publications

  • The actions of melittin on membranes.

    Christopher E. Dempsey

  • Glycophorin A dimerization is driven by specific interactions between transmembrane alpha helices

    M.A. Lemmon;J.M. Flanagan;J.F. Hunt;B.D. Adair

  • The hydration structure of guanidinium and thiocyanate ions: Implications for protein stability in aqueous solution

    PE Mason;GW Neilson;Christopher E Dempsey;Adrian C Barnes

  • Structure, location, and lipid perturbations of melittin at the membrane interface

    Kalina Hristova;Christopher E. Dempsey;Stephen H. White

  • The structure of aqueous guanidinium chloride solutions

    Philip E. Mason;George W. Neilson;John E. Enderby;‖ Marie-Louise Saboungi

  • Hydrogen exchange in peptides and proteins using NMR spectroscopy

    Christopher E. Dempsey

  • Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)

    Matthew P. Crump;John Crosby;Christopher E. Dempsey;John A. Parkinson

  • Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels

    Craig T. Armstrong;Philip E. Mason;J. L. Ross Anderson;Christopher E. Dempsey

  • Contribution of Proline-14 to the structure and actions of melittin

    Christopher E. Dempsey;Renzo Bazzo;Timothy S. Harvey;Inge Syperek

  • Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting

    P.J. Lockyer;J.R. Bottomley;J.S. Reynolds;T.J. McNulty

  • The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.

    Harry J. Witchel;Christopher E. Dempsey;Richard B. Sessions;Matthew Perry

  • Helical structure and orientation of melittin in dispersed phospholipid membranes from amide exchange analysis in situ.

    Christopher E. Dempsey;Georgina S. Butler

  • Origin of Low Mammalian Cell Toxicity in a Class of Highly Active Antimicrobial Amphipathic Helical Peptides

    Ayman Hawrani;Ayman Hawrani;Robin A. Howe;Timothy Rutland Walsh;Christopher E. Dempsey

  • The Interaction of Guanidinium Ions with a Model Peptide

    Philip E. Mason;John W. Brady;George W. Neilson;Christopher E. Dempsey

  • Enhanced Membrane Permeabilization and Antibacterial Activity of a Disulfide-Dimerized Magainin Analogue

    Christopher E. Dempsey;Shohta Ueno;Matthew B. Avison

  • Nanometer-scale ion aggregates in aqueous electrolyte solutions: guanidinium sulfate and guanidinium thiocyanate.

    PE Mason;CE Dempsey;GW Neilson;JW Brady

  • Preferential interactions of guanidinum ions with aromatic groups over aliphatic groups.

    Philip E. Mason;Christopher E. Dempsey;George W. Neilson;Steve R. Kline

  • Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

    James T Milnes;Christopher E Dempsey;John M Ridley;Olivia Crociani

  • Hydrogen bonding in helical polypeptides from molecular dynamics simulations and amide hydrogen exchange analysis: alamethicin and melittin in methanol.

    Richard B. Sessions;Nick Gibbs;Christopher E. Dempsey

  • Helix bending in alamethicin: Molecular dynamics simulations and amide hydrogen exchange in methanol

    N Gibbs;Richard B Sessions;P B Williams;Christopher E Dempsey

Frequent Co-Authors

Philip E. Mason
Philip E. Mason Czech Academy of Sciences
Richard B. Sessions
Richard B. Sessions University of Bristol
John W. Brady
John W. Brady Cornell University
Anthony R. Clarke
Anthony R. Clarke University of Bristol
Anthony Watts
Anthony Watts University of Oxford
Matthew P. Crump
Matthew P. Crump University of Bristol
Anthony Watts
Anthony Watts University of Oxford
Thomas J. Simpson
Thomas J. Simpson University of Bristol
Peter R. Shewry
Peter R. Shewry Rothamsted Research
Timothy R. Walsh
Timothy R. Walsh University of Oxford

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