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Biology and Biochemistry

D-Index
53
Citations
35433
World Ranking
15873
National Ranking
6592

Overview

Anna M. Krichevsky is affiliated with Brigham and Women's Hospital in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and cancer research. The scientist has published extensively in these fields, emphasizing the role of RNA and microRNAs in disease processes.

Their recent publications include:

  • Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells, 2020, Cell Reports
  • Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism, 2020, iScience
  • Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing, 2023, Nature Communications
  • Small Molecule Drugs Targeting Non-Coding RNAs as Treatments for Alzheimer's Disease and Related Dementias, 2021, Genes
  • Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma, 2022, Molecular Cell

The main topics covered by their work include:

  • MicroRNA in disease regulation
  • Cancer-related molecular mechanisms research
  • RNA Research and Splicing
  • Extracellular vesicles in disease
  • RNA modifications and cancer
  • Meningioma and schwannoma management
  • Circular RNAs in diseases

Frequent co-authors collaborating with Anna M. Krichevsky are:

  • Rosalia Rabinovsky
  • Erik J. Uhlmann
  • Evgeny Deforzh
  • Zhiyun Wei
  • Rachid El Fatimy

Common publication venues for the scientist include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Molecular Cell
  • Journal of Neuropathology & Experimental Neurology
  • Journal of Biological Chemistry

Their research predominantly addresses challenges in molecular biology with a strong intersection in cancer research and neurology, investigating mechanisms such as extracellular vesicles, RNA modifications, and microRNA functions across several disease contexts. The work also explores therapeutic approaches involving small molecule drugs targeting non-coding RNAs, including applications relevant to Alzheimer's disease and other dementias.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

    Skog J;Würdinger T;van Rijn S;Meijer Dh

  • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.

    Jennifer A. Chan;Anna M. Krichevsky;Kenneth S. Kosik

  • A microRNA array reveals extensive regulation of microRNAs during brain development

    Anna M. Krichevsky;Kevin S. King;Christine P. Donahue;Konstantin Khrapko

  • miR‐21: a small multi‐faceted RNA

    Anna M. Krichevsky;Galina Gabriely

  • MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

    Galina Gabriely;Thomas Wurdinger;Santosh Kesari;Christine C. Esau

  • MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

    Eugene D Ponomarev;Tatyana Veremeyko;Natasha Barteneva;Anna M Krichevsky

  • Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis

    Anna M. Krichevsky;Kai‐C. Sonntag;Ole Isacson;Kenneth S. Kosik

  • Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

    John Kim;Anna Krichevsky;Yonatan Grad;Gabriel D. Hayes

  • Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation.

    Anna M Krichevsky;Kenneth S Kosik

  • MicroRNA profiling of the murine hematopoietic system

    Silvia Monticelli;Silvia Monticelli;K Mark Ansel;Changchun Xiao;Nicholas D Socci

  • Multidimensional communication in the microenvirons of glioblastoma.

    Marike L. Broekman;Marike L. Broekman;Sybren L. N. Maas;Sybren L. N. Maas;Erik R. Abels;Thorsten R. Mempel

  • miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells

    Thomas Würdinger;Bakhos A. Tannous;Okay Saydam;Johan Skog

  • MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas.

    Maarten F. Corsten;Rafael Miranda;Randa Kasmieh;Anna M. Krichevsky

  • Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

    Oleg Butovsky;Shafiuddin Siddiqui;Galina Gabriely;Amanda J. Lanser

  • Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

    Oleg Butovsky;Mark P. Jedrychowski;Ron Cialic;Susanne Krasemann

  • Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

    Zhiyun Wei;Arsen O. Batagov;Sergio Schinelli;Jintu Wang

  • Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology

    Filip Simunovic;Ming Yi;Yulei Wang;Laurel Macey

  • Human Glioma Growth is Controlled by MicroRNA-10b

    Galina Gabriely;Ming Yi;Ravi S. Narayan;Johanna M. Niers

  • Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/β-Catenin Signaling Pathway

    Okay Saydam;Yiping Shen;Thomas Würdinger;Thomas Würdinger;Ozlem Senol

Frequent Co-Authors

Kenneth S. Kosik
Kenneth S. Kosik University of California, Santa Barbara
Xandra O. Breakefield
Xandra O. Breakefield Harvard University
Philip L. De Jager
Philip L. De Jager Columbia University
Bakhos A. Tannous
Bakhos A. Tannous Harvard University
Lori B. Chibnik
Lori B. Chibnik Harvard University
Howard L. Weiner
Howard L. Weiner Harvard University
Towfique Raj
Towfique Raj Icahn School of Medicine at Mount Sinai
Robert M. Stephens
Robert M. Stephens National Institutes of Health
Oleg Butovsky
Oleg Butovsky Brigham and Women's Hospital
David A. Bennett
David A. Bennett Rush University Medical Center

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