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Biology and Biochemistry

D-Index
56
Citations
20845
World Ranking
14153
National Ranking
5967

Overview

Andrew J. Ewald is affiliated with Johns Hopkins University School of Medicine in the United States. Their research predominantly spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on Oncology, Molecular Biology, Cancer Research, Immunology, and Cell Biology.

Their research topics include:

  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • 3D Printing in Biomedical Research
  • Cellular Mechanics and Interactions
  • Epigenetics and DNA Methylation
  • Single-cell and Spatial Transcriptomics
  • Pancreatic and Hepatic Oncology Research

Recent publications by Andrew J. Ewald cover various aspects of cancer biology and metastasis. These include:

  • "An expanded universe of cancer targets," 2021, published in Cell
  • "Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin," 2022, published in Science Translational Medicine
  • "Cancer cells educate natural killer cells to a metastasis-promoting cell state," 2020, published in The Journal of Cell Biology
  • "A Tissue-Engineered 3D Microvessel Model Reveals the Dynamics of Mosaic Vessel Formation in Breast Cancer," 2020, published in Cancer Research
  • "Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis," 2021, published in Cell Metabolism

Andrew J. Ewald frequently collaborates with several researchers, including Joel S. Bader, Matthew Dunworth, Veena Padmanaban, Isaac S. Chan, and Eloïse M. Grasset.

Their work is often published in journals including:

  • Cancer Research
  • Annals of Surgical Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • The Journal of Cell Biology

This profile reflects Andrew J. Ewald's engagement in cancer-related studies, focusing on the molecular and cellular mechanisms that contribute to cancer metastasis and progression. Their interdisciplinary approach integrates cellular mechanics, genomics, and advanced biomedical modeling techniques to explore tumor biology and metastatic processes.

Best Publications

  • Matrix metalloproteinases and the regulation of tissue remodelling

    Andrea Page-McCaw;Andrew J. Ewald;Zena Werb

  • Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

    Hsiuchen Chen;Scott A. Detmer;Andrew J. Ewald;Erik E. Griffin

  • Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

    Kevin J. Cheung;Edward Gabrielson;Zena Werb;Andrew J. Ewald

  • Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

    Andrew J. Ewald;Audrey Brenot;Myhanh Duong;Bianca S. Chan

  • Three-dimensional organotypic culture: experimental models of mammalian biology and disease

    Eliah R. Shamir;Andrew J. Ewald

  • Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.

    Kevin J. Cheung;Veena Padmanaban;Vanesa L. Silvestri;Koen Schipper

  • E-cadherin is required for metastasis in multiple models of breast cancer.

    Veena Padmanaban;Ilona Krol;Yasir Suhail;Barbara M. Szczerba

  • PDGFRβ + perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

    Steven Song;Andrew J. Ewald;William Stallcup;Zena Werb

  • ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

    Kim Vy Nguyen-Ngoc;Kevin J. Cheung;Audrey Brenot;Eliah R. Shamir

  • A collective route to metastasis: Seeding by tumor cell clusters

    Kevin J. Cheung;Andrew J. Ewald

  • Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

    Elizabeth S. Nakasone;Hanne A. Askautrud;Tim Kees;Jae Hyun Park

  • GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model

    Hosein Kouros-Mehr;Seth K. Bechis;Euan M. Slorach;Laurie E. Littlepage

  • Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.

    Deborah J. Andrew;Andrew J. Ewald

  • Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis

    Fernando Martín-Belmonte;Wei Yu;Alejo E. Rodríguez-Fraticelli;Andrew J. Ewald

  • Twist1-induced dissemination preserves epithelial identity and requires E-cadherin

    Eliah R. Shamir;Elisa Pappalardo;Danielle M. Jorgens;Kester Coutinho

  • A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

    Qian Chen;Nailing Zhang;Ryan S. Gray;Huili Li

  • Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy

    Mikala Egeblad;Andrew J. Ewald;Hanne A. Askautrud;Morgan L. Truitt

  • A Molecular Switch for the Orientation of Epithelial Cell Polarization

    David M. Bryant;Julie Roignot;Anirban Datta;Arend W. Overeem

  • Calcium signaling during convergent extension in Xenopus

    John B. Wallingford;Andrew J. Ewald;Richard M. Harland;Scott E. Fraser

  • The MAPKERK-1,2 pathway integrates distinct and antagonistic signals from TGFα and FGF7 in morphogenesis of mouse mammary epithelium

    Jimmie E. Fata;Hidetoshi Mori;Andrew J. Ewald;Hui Zhang

Frequent Co-Authors

Zena Werb
Zena Werb University of California, San Francisco
Mikala Egeblad
Mikala Egeblad Cold Spring Harbor Laboratory
Joel S. Bader
Joel S. Bader Johns Hopkins University
Matthew F. Krummel
Matthew F. Krummel University of California, San Francisco
Keith E. Mostov
Keith E. Mostov University of California, San Francisco
Scott E. Fraser
Scott E. Fraser University of Southern California
Andre Levchenko
Andre Levchenko Yale University
Rong Li
Rong Li Johns Hopkins University School of Medicine
Elizabeth M. Jaffee
Elizabeth M. Jaffee Johns Hopkins University
John B. Wallingford
John B. Wallingford The University of Texas at Austin

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