Andrea J. Sant

Overview

Best Publications

• Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.

  Seth J. Zost;Kaela Parkhouse;Megan E. Gumina;Kangchon Kim

  584
  Citations

• The Kinetic Stability of MHC Class II:Peptide Complexes Is a Key Parameter that Dictates Immunodominance

  Christopher A. Lazarski;Christopher A. Lazarski;Francisco A. Chaves;Scott A. Jenks;Shenhong Wu

  310
  Citations

• Revealing the role of CD4(+) T cells in viral immunity.

  Andrea J. Sant;Andrew McMichael

  226
  Citations

• The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes.

  Andrea J. Sant;Francisco A. Chaves;Scott A. Jenks;Katherine A. Richards

  175
  Citations

• The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent.

  C C Stebbins;G E Loss;C G Elias;A Chervonsky

  163
  Citations

• MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

  Shouxiong Huang;Susan Gilfillan;Sojung Kim;Bruce Thompson

  156
  Citations

• Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules.

  John E Katz;Christopher Stebbins;Ettore Appella;Andrea J. Sant

  143
  Citations

• Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan.

  A J Sant;S E Cullen;K S Giacoletto;B D Schwartz

  114
  Citations

• Cutting Edge: CD4 T Cells Generated from Encounter with Seasonal Influenza Viruses and Vaccines Have Broad Protein Specificity and Can Directly Recognize Naturally Generated Epitopes Derived from the Live Pandemic H1N1 Virus

  Katherine A. Richards;David Topham;Francisco A. Chaves;Andrea J. Sant

  114
  Citations

• MHC class II antigen processing: biology of invariant chain.

  Andrea J. Sant;Jim Miller

  113
  Citations

• DM determines the cryptic and immunodominant fate of T cell epitopes.

  Navreet K. Nanda;Andrea J. Sant

  108
  Citations

• Invariant chain retains MHC class II molecules in the endocytic pathway.

  G E Loss;A J Sant

  100
  Citations

• CD4+ T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine

  Jennifer L. Nayak;Theresa F. Fitzgerald;Katherine A. Richards;Hongmei Yang

  99
  Citations

• The impact of DM on MHC class II–restricted antigen presentation can be altered by manipulation of MHC–peptide kinetic stability

  Christopher A. Lazarski;Christopher A. Lazarski;Francisco A. Chaves;Andrea J. Sant

  94
  Citations

• Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways.

  G E Loss;C G Elias;P E Fields;R K Ribaudo

  93
  Citations

• Infection of HLA-DR1 Transgenic Mice with a Human Isolate of Influenza A Virus (H1N1) Primes a Diverse CD4 T-Cell Repertoire That Includes CD4 T Cells with Heterosubtypic Cross-Reactivity to Avian (H5N1) Influenza Virus

  Katherine A. Richards;Francisco A. Chaves;Andrea J. Sant

  93
  Citations

• Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin.

  Katherine A. Richards;Francisco A. Chaves;Frederick R. Krafcik;David J. Topham

  89
  Citations

• Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers.

  Benjamin J. McFarland;Andrea J. Sant;Terry P. Lybrand;Craig Beeson

  88
  Citations

• CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus Infection

  Shabnam Alam;Zackery A. G. Knowlden;Mark Y. Sangster;Andrea J. Sant

  85
  Citations

• Cutting Edge: A Single, Essential Hydrogen Bond Controls the Stability of Peptide-MHC Class II Complexes

  Benjamin J. McFarland;Craig Beeson;Andrea J. Sant

  85
  Citations