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Biology and Biochemistry

D-Index
59
Citations
19185
World Ranking
12292
National Ranking
946

Overview

Alan Tunnacliffe is affiliated with the University of Cambridge in the United Kingdom. Their research work spans several fields within the broader areas of biochemistry, genetics, molecular biology, and medicine. The scientist's publications number at least four in these main disciplines, reflecting interdisciplinary expertise across related subfields.

The subfields of study covered by their work include physiology, cell biology, epidemiology, aquatic science, and developmental neuroscience. This variety suggests a research focus that integrates molecular and cellular mechanisms with organismal and environmental biology.

Their main research topics address diverse biological processes and disease-related mechanisms, with an emphasis on:

  • Cellular transport and secretion
  • Calcium signaling and nucleotide metabolism
  • Autophagy in disease and therapy
  • Biochemical effects in animals
  • Echinoderm biology and ecology
  • Anesthesia and neurotoxicity research
  • Microtubule and mitosis dynamics

Alan Tunnacliffe has coauthored work with several frequent collaborators, indicating ongoing joint research efforts. These frequent coauthors include Meng Lü, Gabriele S. Kaminski Schierle, Clemens F. Kaminski, Francesca W. van Tartwijk, and Julie Qiaojin Lin.

The scientist's publications have appeared in journals such as Science Advances, Oxidative Medicine and Cellular Longevity, and bioRxiv (Cold Spring Harbor Laboratory). These venues indicate a focus on advancing knowledge in experimental and translational biomedical sciences.

Recent papers authored or coauthored by Alan Tunnacliffe include:

  • The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes, 2020, Science Advances
  • Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat, 2021, Oxidative Medicine and Cellular Longevity
  • The structure and global distribution of the endoplasmic reticulum network is actively regulated by lysosomes, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

    L M Mulligan;J B Kwok;C S Healey;M J Elsdon

  • Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer

    H. Telenius;N. P. Carter;C. E. Bebb;M. Nordenskjold

  • Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

    Sovan Sarkar;Janet E. Davies;Zebo Huang;Alan Tunnacliffe

  • LEA proteins prevent protein aggregation due to water stress.

    Kshamata Goyal;Laura J. Walton;Alan Tunnacliffe

  • The continuing conundrum of the LEA proteins

    Alan Tunnacliffe;Michael J. Wise

  • Cytogenetic analysis by chromosome painting using dop-pcr amplified flow-sorted chromosomes

    H Telenius;A H Pelmear;A Tunnacliffe;N P Carter

  • Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours

    C Eng;D P Smith;L M Mulligan;M A Nagai

  • POPP the question: what do LEA proteins do?

    Michael J Wise;Alan Tunnacliffe

  • Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia

    Adam Hart;Fabrice Melet;Paul Grossfeld;Kenneth Chien

  • Anhydrobiosis: plant desiccation gene found in a nematode.

    John Browne;Alan Tunnacliffe;Ann Burnell

  • Hydrophilic protein associated with desiccation tolerance exhibits broad protein stabilization function

    Sohini Chakrabortee;Chiara Boschetti;Laura J. Walton;Sovan Sarkar

  • Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes

    Alastair Crisp;Chiara Boschetti;Malcolm Perry;Alan Tunnacliffe

  • Transition from natively unfolded to folded state induced by desiccation in an anhydrobiotic nematode protein.

    Kshamata Goyal;Laurence Tisi;Amrik Basran;John A. Browne

  • Dehydration-induced expression of LEA proteins in an anhydrobiotic chironomid.

    Takahiro Kikawada;Yuichi Nakahara;Yasushi Kanamori;Ken-ichi Iwata

  • Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2

    C. Jones;L. Penny;T. Mattina;S. Yu

  • Anhydrobiosis without trehalose in bdelloid rotifers.

    Jens Lapinski;Alan Tunnacliffe

  • Intrinsically disordered proteins as molecular shields

    Sohini Chakrabortee;Rashmi Tripathi;Matthew Watson;Gabriele S. Kaminski Schierle

  • The gene, MIC4, which controls expression of the antigen defined by monoclonal antibody F10.44.2, is on human chromosome 11.

    Peter N. Goodfellow;George Banting;Michael V. Wiles;Alan Tunnacliffe

  • Biochemical diversification through foreign gene expression in bdelloid rotifers.

    Chiara Boschetti;Adrian Carr;Alastair Crisp;Isobel Eyres

  • Functional divergence of former alleles in an ancient asexual invertebrate.

    Natalia N. Pouchkina-Stantcheva;Brian M. McGee;Chiara Boschetti;Dimitri Tolleter

Frequent Co-Authors

Bruce A.J. Ponder
Bruce A.J. Ponder University of Cambridge
Lois M. Mulligan
Lois M. Mulligan Queen's University
Diego Fontaneto
Diego Fontaneto Water Research Institute
Timothy G. Barraclough
Timothy G. Barraclough University of Oxford
Laura Papi
Laura Papi University of Florence
Sara E. Mole
Sara E. Mole University College London
Catherine S. Healey
Catherine S. Healey University of Cambridge
Charis Eng
Charis Eng Cleveland Clinic Lerner College of Medicine
Donald R. Love
Donald R. Love Auckland City Hospital
Richard W. Titball
Richard W. Titball University of Exeter

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