World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
14708
World Ranking
9172
National Ranking
667

Overview

Achim Aigner is affiliated with Leipzig University in Germany and has a substantial body of research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine.

The main areas of their research encompass Molecular Biology, Oncology, Cancer Research, Pulmonary and Respiratory Medicine, and Immunology. Their work focuses heavily on topics such as RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, MicroRNA in disease regulation, Histone Deacetylase Inhibitors Research, Nanoparticle-Based Drug Delivery, Protein Degradation and Inhibitors, and Cancer Cells and Metastasis.

Recent significant papers authored by or involving Achim Aigner include:

  • Therapeutic siRNA: State-of-the-Art and Future Perspectives, 2022, BioDrugs
  • Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination Strategies and Future Perspectives, 2021, Cancers
  • Nucleic acid delivery with extracellular vesicles, 2021, Advanced Drug Delivery Reviews
  • Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment, 2021, Pharmaceutics
  • Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression, 2021, Journal of Experimental & Clinical Cancer Research

They commonly publish in several journals with frequent contributions to the following venues:

  • Cancers
  • Pharmaceutics
  • Journal of Cancer Research and Clinical Oncology
  • European Journal of Pharmaceutics and Biopharmaceutics
  • Cells

Achim Aigner has collaborated regularly with several co-authors, including:

  • Alexander Ewe
  • Thomas Büch
  • Robert Jenke
  • Michael Karimov
  • Florian Lordick

Best Publications

  • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

    B Urban-Klein;S Werth;S Abuharbeid;F Czubayko

  • Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development.

    Achim Aigner;Patricio E. Ray;Frank Czubayko;Anton Wellstein

  • Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.

    Gerald E. Stoica;Angera Kuo;Achim Aigner;Iruvanti Sunitha

  • MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma

    Ahmed Fawzy Ibrahim;Ulrike Weirauch;Maren Thomas;Arnold Grünweller

  • Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings.

    Jun Zeng;Achim Aigner;Frank Czubayko;Thomas Kissel

  • A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes.

    Stephanie Werth;Beata Urban-Klein;Lige Dai;Sabrina Höbel

  • RNA Interference-Mediated Gene Silencing of Pleiotrophin Through Polyethylenimine-Complexed Small Interfering RNAs In Vivo Exerts Antitumoral Effects in Glioblastoma Xenografts

    Marius Grzelinski;Beata Urban-Klein;Tobias Martens;Katrin Lamszus

  • A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.

    Frank Czubayko;Emmanuelle D.E. Liaudet-Coopman;Achim Aigner;Anne T. Tuveson

  • Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs.

    Achim Aigner

  • Pleiotrophin Signaling through Anaplastic Lymphoma Kinase Is Rate-limiting for Glioblastoma Growth

    Ciaran Powers;Achim Aigner;Gerald E. Stoica;Kevin McDonnell

  • Liposome–polyethylenimine complexes for enhanced DNA and siRNA delivery

    Jens Schäfer;Sabrina Höbel;Udo Bakowsky;Achim Aigner

  • Polyethylenimines for siRNA and miRNA delivery in vivo.

    Sabrina Höbel;Achim Aigner

  • Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung

    Melanie Günther;Jens Lipka;Anastasia Malek;Daniela Gutsch

  • In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes.

    Anastasia Malek;Olivia Merkel;Ludger Fink;Frank Czubayko

  • Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

    Norman Ertych;Ailine Stolz;Albrecht Stenzinger;Wilko Weichert

  • From the exposome to mechanistic understanding of chemical-induced adverse effects

    Beate I. Escher;Jörg Hackermüller;Tobias Polte;Stefan Scholz

  • Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo.

    Achim Aigner

  • The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells.

    Judith von Haussen;Rembert Koczulla;Renat Shaykhiev;Christian Herr

  • Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein

    Elena Tassi;Ali Al-Attar;Achim Aigner;Matthew R. Swift

  • PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacy.

    Anastasia Malek;Frank Czubayko;Achim Aigner

Frequent Co-Authors

Roland K. Hartmann
Roland K. Hartmann Philipp University of Marburg
Thomas Gudermann
Thomas Gudermann Ludwig-Maximilians-Universität München
Dietmar Appelhans
Dietmar Appelhans Leibniz Institute for Neurobiology
Udo Bakowsky
Udo Bakowsky Philipp University of Marburg
Thomas Kissel
Thomas Kissel Philipp University of Marburg
Brigitte Voit
Brigitte Voit Leibniz-Institut für Polymerforschung Dresden e. V.
Ingo Bechmann
Ingo Bechmann Leipzig University
Florian Lordick
Florian Lordick Leipzig University
Donat Kögel
Donat Kögel Goethe University Frankfurt
Joachim H. Wendorff
Joachim H. Wendorff Philipp University of Marburg

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry can open doors to several related fields in health and science. Many students consider a kinesiology degree online to understand human movement and health, which complements a strong biology background.

For those interested in the mental health field, accelerated programs such as the fastest pmhnp program can lead to roles as psychiatric mental health nurse practitioners. Similarly, the 12-month fnp program online provides a quick path for nurses to advance their clinical careers.

Nutrition is another popular pathway, closely linked with biochemistry. A dietitian degree online offers practical skills in dietary science and public health.

Choosing an online program gives you flexibility and access to specialized fields that build on your foundational science knowledge. These diverse options can help you shape a career tailored to your interests in health, research, or clinical practice.

Best Scientists Citing Achim Aigner

Trending Scientists