World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
11772
World Ranking
15534
National Ranking
446

Overview

Zusen Fan is affiliated with the Chinese Academy of Sciences in China and has a research portfolio that spans biochemistry, genetics, molecular biology, immunology, microbiology, and medicine. Their work focuses on several interconnected disciplines, including molecular biology, immunology, cancer research, surgery, and oncology.

Fan's research covers diverse topics with a particular emphasis on circular RNAs in diseases, IL-33, ST2, and innate lymphoid cell (ILC) pathways, immune cell function and interaction, microRNA in disease regulation, cancer-related molecular mechanisms, RNA modifications and cancer, and eosinophilic esophagitis.

They have published extensively in prominent journals, with frequent contributions to:

  • Nature Communications
  • Cell Research
  • Cellular and Molecular Immunology
  • The EMBO Journal
  • The Journal of Experimental Medicine

Notable recent papers include:

  • "N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism," 2021, Nature Communications
  • "Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling," 2021, Molecular Cancer
  • "Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer," 2020, Cell Research
  • "5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis," 2022, Neuron
  • "Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons," 2022, Cell Research

Fan has collaborated frequently with several coauthors, including Yong Tian, Pingping Zhu, Xiaoxiao Zhu, Benyu Liu, and Ying Du. These collaborations reflect an interdisciplinary approach, often intersecting immunology and cancer research.

Best Publications

  • Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.

    Zusen Fan;Paul J. Beresford;David Y. Oh;Dong Zhang

  • The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling

    Yanying Wang;Lei He;Ying Du;Pingping Zhu

  • Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation

    Shuo Wang;Pengyan Xia;Yi Chen;Yuan Qu

  • Cleaving the Oxidative Repair Protein Ape1 Enhances Cell Death Mediated by Granzyme A

    Zusen Fan;Paul J. Beresford;Dong Zhang;Zhan Xu

  • A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.

    Pengyan Xia;Shuo Wang;Buqing Ye;Ying Du

  • Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells.

    S Liu;H Zhang;M Li;D Hu

  • LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

    Pingping Zhu;Yanying Wang;Jiayi Wu;Guanling Huang

  • Nuclear war: the granzyme A-bomb

    Judy Lieberman;Zusen Fan

  • T-cell Immunoglobulin and ITIM Domain (TIGIT) Receptor/Poliovirus Receptor (PVR) Ligand Engagement Suppresses Interferon-γ Production of Natural Killer Cells via β-Arrestin 2-mediated Negative Signaling

    Man Li;Pengyan Xia;Ying Du;Shengwu Liu

  • Granzyme A Activates an Endoplasmic Reticulum-associated Caspase-independent Nuclease to Induce Single-stranded DNA Nicks

    Paul J. Beresford;Dong Zhang;David Y. Oh;Zusen Fan

  • lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

    Pingping Zhu;Yanying Wang;Guanling Huang;Buqing Ye

  • NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors

    Zusen Fan;Ping Yu;Ping Yu;Yang Wang;Yang Wang;Yugang Wang;Yugang Wang

  • Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a.

    Xinlong Yan;Dongdong Zhang;Wei Wu;Shuheng Wu

  • Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis

    Guoqiang Hua;Qixiang Zhang;Zusen Fan

  • Transient Activation of Autophagy via Sox2-Mediated Suppression of mTOR Is an Important Early Step in Reprogramming to Pluripotency

    Shuo Wang;Pengyan Xia;Buqing Ye;Guanling Huang

  • Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

    Pengyan Xia;Buqing Ye;Shuo Wang;Xiaoxiao Zhu

  • HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.

    Zusen Fan;Paul J. Beresford;Dong Zhang;Judy Lieberman

  • Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression

    Benyu Liu;Buqing Ye;Liuliu Yang;Xiaoxiao Zhu

  • WASH inhibits autophagy through suppression of Beclin 1 ubiquitination.

    Pengyan Xia;Shuo Wang;Ying Du;Zhenao Zhao

  • Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme

    Z Fan

Frequent Co-Authors

Shuo Wang
Shuo Wang Nankai University
Runsheng Chen
Runsheng Chen Chinese Academy of Sciences
Judy Lieberman
Judy Lieberman Boston Children's Hospital
Ze-Guang Han
Ze-Guang Han Shanghai Jiao Tong University
Liang Tong
Liang Tong Columbia University
Jing Liu
Jing Liu Chinese Academy of Sciences
Xiao Yang
Xiao Yang Shanghai Jiao Tong University
Hong Liu
Hong Liu Shandong University
Feng Xu
Feng Xu Xi'an Jiaotong University
Yu-Guo Guo
Yu-Guo Guo Chinese Academy of Sciences

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