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Vishwanath R. Lingappa

Vishwanath R. Lingappa

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
11000
World Ranking
13282
National Ranking
5652

Overview

Vishwanath R. Lingappa is affiliated with Prosetta Biosciences in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Infectious Diseases, Virology, Neurology, and Epidemiology.

The scientist's work addresses multiple topics including HIV Research and Treatment, Amyotrophic Lateral Sclerosis Research, HIV/AIDS drug development and treatment, Ubiquitin and proteasome pathways, Virus-based gene therapy research, HIV/AIDS Research and Interventions, and 14-3-3 protein interactions.

They have published several papers in various research venues. Notable recent papers include:

  • Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation (2020) in Proceedings of the National Academy of Sciences
  • New methylene blue derivatives suggest novel anti-orthopoxviral strategies (2021) in Antiviral Research
  • Addressing Antiretroviral Drug Resistance with Host-Targeting Drugs-First Steps towards Developing a Host-Targeting HIV-1 Assembly Inhibitor (2021) in Viruses
  • Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly (2020) in Journal of Virology
  • Determination of the membrane topology of PORCN, an O-acyl transferase that modifies Wnt signalling proteins (2021) in Open Biology

Frequent publication venues for their work include bioRxiv (Cold Spring Harbor Laboratory), Open Biology, Bioscience Reports, Proceedings of the National Academy of Sciences, and Antiviral Research.

They have collaborated extensively with several coauthors, including:

  • Dennis Solas
  • Anuradha F. Lingappa
  • Maya Michon
  • Carsten Korth
  • Jaisri R. Lingappa

Best Publications

  • A transmembrane form of the prion protein in neurodegenerative disease.

    Ramanujan S. Hegde;James A. Mastrianni;Michael R. Scott;Kathryn A. DeFea

  • Mechanism of protein translocation across the endoplasmic reticulum membrane.

    Peter Walter;Vishwanath R. Lingappa

  • Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein.

    Flora N. Katz;James E. Rothman;Vishwanath R. Lingappa;Günter Blobel

  • Transmissible and genetic prion diseases share a common pathway of neurodegeneration

    Ramanujan S. Hegde;Patrick Tremblay;Darlene Groth;Stephen J. DeArmond

  • Rapid regulation of steroidogenesis by mitochondrial protein import

    Himangshu S. Bose;Vishwanath R. Lingappa;Walter L. Miller

  • A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function.

    V.R. Lingappa;F.N. Katz;H.F. Lodish;G. Blobel

  • Chicken ovalbumin contains an internal signal sequence.

    Vishwanath R. Lingappa;Jaisri R. Lingappa;Günter Blobel

  • Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin

    Vishwanath R. Lingappa;Anne Devillers-Thiery;Gunter Blobel

  • Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis

    Arie Gruzman;William L. Wood;Evgenia Alpert;M. Dharma Prasad

  • Uncoupling translocation from translation: implications for transport of proteins across membranes

    Eve Perara;Richard E. Rothman;Vishwanath R. Lingappa

  • Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein.

    Vishwanath R. Lingappa;Jaisri R. Lingappa;Rajani Prasad;Kurt E. Ebner

  • Translocation of proteins across membranes: the signal hypothesis and beyond.

    G Blobel;P Walter;C N Chang;B M Goldman

  • Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide.

    B E Eble;V R Lingappa;D Ganem

  • Unusual topogenic sequence directs prion protein biogenesis.

    Charles D. Lopez;C. Spencer Yost;Stanley B. Prusiner;Richard M. Myers

  • Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein

    C S Yost;C D Lopez;S B Prusiner;R M Myers

  • Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

    W R Skach;M C Calayag;V R Lingappa

  • A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems.

    C. Spencer Yost;Joe Hedgpeth;Vishwanath R. Lingappa

  • A multifunctional aqueous channel formed by CFTR.

    H Hasegawa;W Skach;O Baker;MC Calayag

  • A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle.

    Jaisri R. Lingappa;Robert L. Martin;Mei Lie Wong;Don Ganem

  • Pause transfer: a topogenic sequence in apolipoprotein B mediates stopping and restarting of translocation.

    Steven L. Chuck;Vishwanath R. Lingappa

Frequent Co-Authors

Ramanujan S. Hegde
Ramanujan S. Hegde MRC Laboratory of Molecular Biology
Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Don Ganem
Don Ganem Via Nova Therapeutics
William R. Skach
William R. Skach Cystic Fibrosis Foundation
David W. Andrews
David W. Andrews Sunnybrook Health Science Centre
Stephen J. DeArmond
Stephen J. DeArmond University of California, San Francisco
Peter Walter
Peter Walter University of California, San Francisco
Bruce A. Hay
Bruce A. Hay California Institute of Technology
Walter L. Miller
Walter L. Miller University of California, San Francisco
Richard M. Myers
Richard M. Myers HudsonAlpha Institute for Biotechnology

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