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Toshio Imai

Toshio Imai

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
23890
World Ranking
5508
National Ranking
355

Overview

Toshio Imai is affiliated with Kindai University in Japan and has an extensive publication record primarily in the field of Medicine, with a focus on Oncology, Molecular Biology, Pulmonary and Respiratory Medicine, Rheumatology, and Radiology, Nuclear Medicine and Imaging.

The scientist's recent papers include the following:

  • Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma (2024, Journal of Gastroenterology)
  • Emerging Role of Fractalkine in the Treatment of Rheumatic Diseases (2020, ImmunoTargets and Therapy)
  • An organoid-based carcinogenesis model induced by in vitro chemical treatment (2020, Carcinogenesis)
  • Efficacy and Safety of E6011, an Anti-Fractalkine Monoclonal Antibody, in Patients With Active Rheumatoid Arthritis With Inadequate Response to Methotrexate: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Study (2020, Arthritis & Rheumatology)
  • Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma (2021, Cancer Letters)

Imai has collaborated frequently with scholars in the field, including Tetsu Kawano, Seiichiro Hojo, Nobuyuki Yasuda, Toshihiro Nanki, and Mie Naruse.

The publication venues that frequently feature Imai's work are:

  • Modern Rheumatology
  • Journal of Gastroenterology
  • Cancer Research Communications
  • Oncology Letters
  • Journal of Toxicologic Pathology

The primary areas of study pursued include Medicine overall, with specialized attention to Oncology, Molecular Biology, Pulmonary and Respiratory Medicine, Rheumatology, and imaging techniques connected to Radiology and Nuclear Medicine.

Research topics addressed by Imai cover several biomedical themes, notably:

  • Chemokine receptors and signaling
  • Cancer Cells and Metastasis
  • Monoclonal and Polyclonal Antibodies Research
  • Systemic Lupus Erythematosus Research
  • Chronic Lymphocytic Leukemia Research
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Liver Disease Diagnosis and Treatment

Best Publications

  • Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion

    Toshio Imai;Kunio Hieshima;Christopher Haskell;Masataka Baba

  • Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine

    Toshio Imai;Morio Nagira;Shin Takagi;Mayumi Kakizaki

  • Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow

    Alan M. Fong;Lisa A. Robinson;Douglas A. Steeber;Thomas F. Tedder

  • Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties.

    Silvano Sozzani;Paola Allavena;Giovanna D’Amico;Walter Luini

  • The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4

    Toshio Imai;Masataka Baba;Miyuki Nishimura;Mayumi Kakizaki

  • Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine, and Identification of a Specific Eosinophil Eotaxin Receptor, CC Chemokine Receptor 3

    Motoji Kitaura;Toshihiro Nakajima;Toshio Imai;Shigenori Harada

  • Chemokines in immunity.

    Osamu Yoshie;Toshio Imai;Hisayuki Nomiyama

  • Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC

    Masataka Baba;Toshio Imai;Miyuki Nishimura;Mayumi Kakizaki

  • Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.

    Ryu Yoshida;Toshio Imai;Kunio Hieshima;Jun Kusuda

  • Selective expression of a novel surface molecule by human Th2 cells in vivo.

    Kinya Nagata;Kazuya Tanaka;Kazuyuki Ogawa;Kazumi Kemmotsu

  • Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2

    Kunio Hieshima;Toshio Imai;Ghislain Opdenakker;Jo Van Damme

  • Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis–like lesions

    Christian Vestergaard;Hiroyuki Yoneyama;Masako Murai;Kohichiro Nakamura

  • Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.

    Toshio Imai;David Chantry;Carol J. Raport;Christi L. Wood

  • Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7.

    Ryu Yoshida;Morio Nagira;Motoji Kitaura;Noriko Imagawa

  • Molecular Cloning of a Novel T Cell-directed CC Chemokine Expressed in Thymus by Signal Sequence Trap Using Epstein-Barr Virus Vector *

    Toshio Imai;Tetsuya Yoshida;Masataka Baba;Miyuki Nishimura

  • Fractalkine in Vascular Biology. From Basic Research to Clinical Disease

    Hisanori Umehara;Eda T. Bloom;Toshiro Okazaki;Yutaka Nagano

  • A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.

    K Hieshima;T Imai;M Baba;K Shoudai

  • Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13

    Morio Nagira;Toshio Imai;Kunio Hieshima;Jun Kusuda

  • Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells.

    Yuichi Ono;Tomoya Nakatani;Yoshimasa Sakamoto;Eri Mizuhara

  • Dual Functions of Fractalkine/CX3C Ligand 1 in Trafficking of Perforin+/Granzyme B+ Cytotoxic Effector Lymphocytes That Are Defined by CX3CR1 Expression

    Miyuki Nishimura;Hisanori Umehara;Takashi Nakayama;Osamu Yoneda

Frequent Co-Authors

Osamu Yoshie
Osamu Yoshie Kindai University
Hisayuki Nomiyama
Hisayuki Nomiyama Kumamoto University
Kouji Matsushima
Kouji Matsushima Tokyo University of Science
Yoshimi Takai
Yoshimi Takai Kobe University
Yoshiya Tanaka
Yoshiya Tanaka University of Occupational and Environmental Health Japan
Naoto Ishii
Naoto Ishii Tohoku University
Tsutomu Takeuchi
Tsutomu Takeuchi Keio University
Nobuyuki Miyasaka
Nobuyuki Miyasaka Tokyo Medical and Dental University
Mikio Furuse
Mikio Furuse The Graduate University for Advanced Studies, SOKENDAI
Hisashi Yamanaka
Hisashi Yamanaka International University of Health and Welfare

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