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D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
27246
World Ranking
5478
National Ranking
2600

Overview

Richard W. Kriwacki is affiliated with St. Jude Children's Research Hospital in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology, Oncology, Hematology, Public Health, Environmental and Occupational Health, and Immunology.

The scientist has contributed extensively to topics including:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Nuclear Structure and Function
  • Genomics and Chromatin Dynamics
  • Acute Myeloid Leukemia Research
  • Protein Structure and Dynamics

Several notable recent papers illustrate the scope and impact of their work:

  • "Composition-dependent thermodynamics of intracellular phase separation," 2020, Nature
  • "LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation," 2022, Nature Immunology
  • "Viscoelasticity and advective flow of RNA underlies nucleolar form and function," 2023, Molecular Cell
  • "The genomic basis of childhood T-lineage acute lymphoblastic leukaemia," 2024, Nature
  • "Phase Separation in Biology and Disease; Current Perspectives and Open Questions," 2023, Journal of Molecular Biology

Kriwacki has collaborated frequently with a core group of coauthors, reflecting ongoing research partnerships. These include Aaron H. Phillips, Swarnendu Tripathi, Hazheen K. Shirnekhi, Bappaditya Chandra, and Charles G. Mullighan.

The scientist's work has appeared regularly in several publication venues, with multiple contributions to:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Biology
  • Neuro-Oncology
  • Molecular Cell

Best Publications

  • Classification of intrinsically disordered regions and proteins.

    Robin van der Lee;Robin van der Lee;Marija Buljan;Benjamin Lang;Robert J. Weatheritt

  • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

    Jinghui Zhang;Li Ding;Linda Holmfeldt;Gang Wu

  • Coexisting Liquid Phases Underlie Nucleolar Subcompartments

    Marina Feric;Nilesh Vaidya;Tyler S. Harmon;Diana M. Mitrea

  • The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

    Gang Wu;Alexander K Diaz;Alexander K Diaz;Barbara S Paugh;Sherri L Rankin

  • The whole-genome landscape of medulloblastoma subtypes

    Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Ivo Buchhalter;A. Sorana Morrissy;Volker Hovestadt

  • Novel mutations target distinct subgroups of medulloblastoma

    Giles Robinson;Matthew Parker;Tanya A. Kranenburg;Charles Lu;Charles Lu

  • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

    Jinghui Zhang;Gang Wu;Claudia P. Miller;Ruth G. Tatevossian

  • Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity

    Richard W. Kriwacki;Ludger Hengst;Linda Tennant;Steven I. Reed

  • C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.

    Kyung Ha Lee;Peipei Zhang;Hong Joo Kim;Diana M. Mitrea

  • Phase separation in biology; functional organization of a higher order

    Diana M. Mitrea;Richard W. Kriwacki;Richard W. Kriwacki

  • Composition-dependent thermodynamics of intracellular phase separation

    Joshua A. Riback;Lian Zhu;Mylene C. Ferrolino;Michele Tolbert

  • Many players in BCL-2 family affairs.

    Tudor Moldoveanu;Ariele Viacava Follis;Richard W. Kriwacki;Douglas R. Green

  • The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.

    Anna K. Andersson;Anna K. Andersson;Jing Ma;Jianmin Wang;Xiang Chen

  • Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

    Diana M Mitrea;Jaclyn A Cika;Jaclyn A Cika;Clifford S Guy;David Ban

  • The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

    Robert Huether;Li Dong;Xiang Chen;Gang Wu

  • Cdk-Inhibitory Activity and Stability of p27Kip1 Are Directly Regulated by Oncogenic Tyrosine Kinases

    Matthias Grimmler;Yuefeng Wang;Thomas Mund;Zoran Cilenšek

  • Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

    Jason D. Weber;Mei-Ling Kuo;Brian Bothner;Brian Bothner;Enrico L. DiGiammarino

  • p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding.

    Eilyn R Lacy;Igor Filippov;William S Lewis;Steve Otieno;Steve Otieno

  • A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer

    Enrico L DiGiammarino;Amanda S Lee;Craig Cadwell;Weixing Zhang

  • Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

    J. Kallen;K. Welzenbach;P. Ramage;D. Geyl

Frequent Co-Authors

Peter Tompa
Peter Tompa Vrije Universiteit Brussel
Peter E. Wright
Peter E. Wright Scripps Research Institute
John Easton
John Easton St. Jude Children's Research Hospital
Brian Bothner
Brian Bothner Montana State University
Gang Wu
Gang Wu St. Jude Children's Research Hospital
Jinghui Zhang
Jinghui Zhang St. Jude Children's Research Hospital
Li Ding
Li Ding Washington University in St. Louis
Michael Rusch
Michael Rusch St. Jude Children's Research Hospital
Elaine R. Mardis
Elaine R. Mardis The Ohio State University
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital

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