Peter van der Ley

Best Publications

• Topology of outer membrane porins in pathogenic Neisseria spp.

  P van der Ley;J E Heckels;M Virji;P Hoogerhout

  420
  Citations

• Outer membrane vesicles as platform vaccine technology

  Unknown

  418
  Citations

• Meningitis bacterium is viable without endotoxin

  Unknown

  416
  Citations

• Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity.

  Peter van der Ley;Liana Steeghs;Hendrik Jan Hamstra;Jan ten Hove

  318
  Citations

• Production, characterization and control of a Neisseria meningitidis hexavalent class 1 outer membrane protein containing vesicle vaccine

  Unknown

  308
  Citations

• Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process.

  Bas van de Waterbeemd;Mathieu Streefland;Peter van der Ley;Bert Zomer

  244
  Citations

• A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via toll-like receptor (TLR) 2 but not via TLR4/MD2.

  Alison C. Pridmore;David H. Wyllie;Fatumo Abdillahi;Liana Steeghs

  224
  Citations

• A Neisserial autotransporter NalP modulating the processing of other autotransporters.

  Peter Van Ulsen;Loek Van Alphen;Jan Ten Hove;Floris Fransen

  196
  Citations

• The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis.

  Michael P. Jennings;Yogitha N. Srikhanta;E. Richard Moxon;Marco Kramer

  163
  Citations

• Phase I clinical trial with a hexavalent PorA containing meningococcal outer membrane vesicle vaccine

  Unknown

  162
  Citations

• The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium–host interaction

  B. J. Appelmelk;J. Den Dunnen;N. N. Driessen;R. Ummels

  157
  Citations

• Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate.

  Unknown

  131
  Citations

• Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidis.

  Michael P. Jennings;Mumtaz Virji;Debbie Evans;Virginia Foster

  130
  Citations

• Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function

  Liana Steeghs;Sandra J van Vliet;Heli Uronen-Hansson;Andries van Mourik

  123
  Citations

• Shielding of Escherichia coli outer membrane proteins as receptors for bacteriophages and colicins by O-antigenic chains of lipopolysaccharide

  Unknown

  118
  Citations

• Trichinella spiralis-secreted products modulate DC functionality and expand regulatory T cells in vitro

  C. Aranzamendi;F. Fransen;M. Langelaar;F. Franssen

  116
  Citations

• Expression of the lipopolysaccharide-modifying enzymes PagP and PagL modulates the endotoxic activity of Bordetella pertussis.

  Jeroen Geurtsen;Liana Steeghs;Hendrik-Jan Hamstra;Jan ten Hove

  112
  Citations

• Cysteine depletion causes oxidative stress and triggers outer membrane vesicle release by Neisseria meningitidis; implications for vaccine development.

  Unknown

  111
  Citations

• Immunogenicity of outer membrane proteins in a lipopolysaccharide-deficient mutant of Neisseria meningitidis: influence of adjuvants on the immune response.

  Liana Steeghs;Betsy Kuipers;Hendrik Jan Hamstra;Gideon Kersten

  110
  Citations

• Construction of a multivalent meningococcal vaccine strain based on the class 1 outer membrane protein

  Unknown

  110
  Citations