Paul J. Maddon

Overview

Best Publications

• HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

  Tatjana Dragic;Virginia Litwin;Graham P. Allaway;Scott R. Martin

  4323
  Citations

• The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.

  Paul Jay Maddon;Angus G. Dalgleish;J.Steven McDougal;Paul R. Clapham

  2848
  Citations

• CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

  Alexandra Trkola;Tatjana Dragic;James Arthos;James M. Binley

  1439
  Citations

• AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

  G A Donzella;D Schols;S W Lin;J A Esté

  994
  Citations

• The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

  Paul Jay Maddon;Dan R. Littman;Maurice Godfrey;Douglas E. Maddon

  862
  Citations

• A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure

  James M. Binley;Rogier W. Sanders;Brian Clas;Norbert Schuelke

  813
  Citations

• A soluble form of CD4 (T4) protein inhibits AIDS virus infection.

  K C Deen;J S McDougal;R Inacker;G Folena-Wasserman

  701
  Citations

• Stabilization of the Soluble, Cleaved, Trimeric Form of the Envelope Glycoprotein Complex of Human Immunodeficiency Virus Type 1

  Rogier W. Sanders;Mika Vesanen;Norbert Schuelke;Aditi Master

  679
  Citations

• Identification of the Residues in Human CD4 Critical for the Binding of HIV

  J Arthos;K C Deen;M A Chaikin;J A Fornwald

  532
  Citations

• Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

  Paul R. Clapham;Jonathan N. Weber;Denise Whitby;Kenneth McIntosh;Kenneth McIntosh

  517
  Citations

• Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

  Paul Maddon;Rafick Sekaly;Mary Anne Talle

  484
  Citations

• The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes

  Dan R. Littman;Yolène Thomas;Paul J. Maddon;Leonard Chess

  460
  Citations

• L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus.

  Jason P. Gardner;Robert J. Durso;Robert R. Arrigale;Gerald P. Donovan

  421
  Citations

• The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy

  Norbert Schülke;Olga A. Varlamova;Gerald P. Donovan;Dangshe Ma

  354
  Citations

• Potent, Broad-Spectrum Inhibition of Human Immunodeficiency Virus Type 1 by the CCR5 Monoclonal Antibody PRO 140

  Alexandra Trkola;Thomas J. Ketas;Kirsten A. Nagashima;Lu Zhao

  346
  Citations

• Differential Inhibition of Human Immunodeficiency Virus Type 1 Fusion, gp120 Binding, and CC-Chemokine Activity by Monoclonal Antibodies to CCR5

  William C. Olson;Gwénaël E. E. Rabut;Kirsten A. Nagashima;Diep N. H. Tran

  328
  Citations

• Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry

  Tatjana Dragic;Alexandra Trkola;Steven W. Lin;Kirsten A. Nagashima

  321
  Citations

• HIV infection does not require endocytosis of its receptor, CD4.

  Paul Jay Maddon;J. Steven McDougal;Paul R. Clapham;Angus G. Dalgleish

  314
  Citations

• Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults

  Jeffrey M. Jacobson;Israel Lowy;Courtney V. Fletcher;Tobias J. O'Neill

  218
  Citations

• Structure and expression of the human and mouse T4 genes

  Paul Jay Maddon;Susan M. Molineaux;Douglas E. Maddon;Kathryn A. Zimmerman

  215
  Citations