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Genetics

D-Index
71
Citations
20382
World Ranking
2186
National Ranking
160

Overview

Manfred Gessler is affiliated with the University of Würzburg in Germany and has a research focus encompassing biochemistry, genetics, molecular biology, and medicine. Their work spans several specialized subfields, including molecular biology, pulmonary and respiratory medicine, cancer research, pediatrics, perinatology, and child health, as well as pathology and forensic medicine.

The scientist's research themes predominantly address renal and related cancers, with notable attention to renal cell carcinoma treatment. Their work also explores ethics and legal issues in pediatric healthcare, cancer genomics and diagnostics, tumors and oncological cases, sarcoma diagnosis and treatment, and pancreatic and hepatic oncology research.

Recent publications include:

  • "Sarcoma classification by DNA methylation profiling", 2021, Nature Communications
  • "Wilms tumour", 2021, Nature Reviews Disease Primers
  • "Genomic characterization of DICER1-associated neoplasms uncovers molecular classes", 2023, Nature Communications
  • "Characteristics and outcome of pediatric renal cell carcinoma patients registered in the International Society of Pediatric Oncology (SIOP) 93-01, 2001 and UK-IMPORT database: A report of the SIOP-Renal Tumor Study Group", 2021, International Journal of Cancer
  • "MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates", 2021, Cancer Cell International

Frequent co-authors collaborating with Manfred Gessler include:

  • Norbert Graf
  • Rhoikos Furtwängler
  • Christian Vokuhl
  • Jenny Wegert
  • Kathy Pritchard-Jones

Their research has been published regularly in several scientific venues, notably:

  • Nature Communications
  • International Journal of Cancer
  • Pediatric Blood & Cancer
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)

Manfred Gessler's contributions encompass 40 publications in biochemistry, genetics, and molecular biology, with 34 works related to medicine. Their subfield expertise in molecular biology is reflected in 32 publications, while pulmonary and respiratory medicine accounts for 18, and cancer research and pediatrics each feature in multiple works.

Best Publications

  • Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

    Manfred Gessler;Annemarie Poustka;Webster Cavenee;Rachael L. Neve

  • The landscape of genomic alterations across childhood cancers

    Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter

  • A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease

    Benoit G. Bruneau;Georges Nemer;Joachim P. Schmitt;Frédéric Charron

  • The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

    Andreas Fischer;Nina Schumacher;Manfred Maier;Michael Sendtner

  • GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

    Andrea Vortkamp;Manfred Gessler;Karl-Heinz Grzeschik

  • Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

    Sakura Saburi;Ian Hester;Evelyne Fischer;Marco Pontoglio

  • Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

    Connie R Bezzina;Julien Barc;Yuka Mizusawa;Carol Ann Remme

  • Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors

    Andreas Fischer;Manfred Gessler

  • Frasier Syndrome is Caused by Defective Alternative Splicing of WT1 Leading to an Altered Ratio of WT1 +/−KTS Splice Isoforms

    Barbara Klamt;Ania Koziell;Francis Poulat;Peter Wieacker

  • Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

    Bernhard Bielesz;Yasemin Sirin;Yasemin Sirin;Han Si;Thiruvur Niranjan

  • Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations.

    Nicolas Sévenet;Arielle Lellouch-Tubiana;Deborah Schofield;Khe Hoang-Xuan

  • Sarcoma classification by DNA methylation profiling

    Christian Koelsche;Christian Koelsche;Daniel Schrimpf;Daniel Schrimpf;Damian Stichel;Martin Sill

  • Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol.

    Marry M. Van Den Heuvel-Eibrink;Janna A. Hol;Kathy Pritchard-Jones;Harm van Tinteren

  • Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.

    Cornelia Leimeister;Alexandra Externbrink;Barbara Klamt;Manfred Gessler

  • Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

    Jenny Wegert;Naveed Ishaque;Romina Vardapour;Christina Geörg

  • Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.

    Manfred M. Maier;Manfred Gessler

  • Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways

    Xiaoyu Hu;Allen Y. Chung;Indira Wu;Julia Foldi

  • Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate.

    Holger Diez;Andreas Fischer;Anja Winkler;Cheng-Jun Hu

  • Hey2 Regulation by FGF Provides a Notch-Independent Mechanism for Maintaining Pillar Cell Fate in the Organ of Corti

    Angelika Doetzlhofer;Martin L. Basch;Takahiro Ohyama;Manfred Gessler

  • DEVELOPMENTAL EXPRESSION PATTERNS OF MOUSE SFRP GENES ENCODING MEMBERS OF THE SECRETED FRIZZLED RELATED PROTEIN FAMILY

    Cornelia Leimeister;Alexandra Bach;Manfred Gessler

Frequent Co-Authors

Norbert Graf
Norbert Graf Saarland University
Kathy Pritchard-Jones
Kathy Pritchard-Jones University College London
Marcel Kool
Marcel Kool German Cancer Research Center
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Karl-Heinz Grzeschik
Karl-Heinz Grzeschik Philipp University of Marburg
Andreas Keller
Andreas Keller Saarland University
Eckart Meese
Eckart Meese Saarland University
Hans-Peter Lenhof
Hans-Peter Lenhof Saarland University
Neil J. Sebire
Neil J. Sebire Great Ormond Street Hospital
David Gisselsson
David Gisselsson Lund University

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