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Genetics

D-Index
70
Citations
21522
World Ranking
2252
National Ranking
1011

Overview

Lawrence C. Brody is affiliated with the National Institutes of Health in the United States. Their research spans several key fields within biochemistry, genetics, molecular biology, and medicine. The primary areas of focus include genetics, molecular biology, rheumatology, surgery, and clinical biochemistry.

The major research topics covered by Brody consist of folate and B vitamins research, metabolism and genetic disorders, mitochondrial function and pathology, genomics and rare diseases, genetic associations and epidemiology, forensic and genetic research, and considerations of race, genetics, and society.

Brody has contributed to a range of academic venues, with frequent publications appearing in:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Medical Genetics Part A
  • Journal of Nutrition
  • Birth Defects Research

Their notable recent papers include:

  • "Strategic vision for improving human health at The Forefront of Genomics," 2020, Nature
  • "GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture," 2023, Nature Genetics
  • "Evolving use of ancestry, ethnicity, and race in genetics research-A survey spanning seven decades," 2021, The American Journal of Human Genetics
  • "The role of common genetic variation in presumed monogenic epilepsies," 2022, EBioMedicine
  • "A genome-wide association study implicates the BMP7 locus as a risk factor for nonsyndromic metopic craniosynostosis," 2020, Human Genetics

Collaboration forms an important part of Brody's work, with frequent coauthors including:

  • Faith Pangilinan
  • Paul A. Romitti
  • Denise M. Kay
  • Mary M. Jenkins
  • Jennita Reefhuis

Their interdisciplinary work integrates genetics with epidemiology and clinical applications, reflecting a strong interest in the societal implications of genetic research. This includes exploring ancestry, ethnicity, and race within the context of genetics over an extended period.

Best Publications

  • The Risk of Cancer Associated with Specific Mutations of BRCA1 and BRCA2 among Ashkenazi Jews

    Jeffery P. Struewing;Patricia Hartge;Sholom Wacholder;Sonya M. Baker

  • Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis.

    Joseph G. Hacia;Lawrence C. Brody;Mark S. Chee;Stephen P.A. Fodor

  • The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals

    Jeffery P. Struewing;Dvorah Abeliovich;Tamar Peretz;Naaman Avishai

  • A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4

    Terri H. Beaty;Jeffrey C. Murray;Mary L. Marazita;Ronald G. Munger

  • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.

    Ronit I. Yarden;Sherly Pardo-Reoyo;Magda Sgagias;Kenneth H. Cowan

  • A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene: Implications for Presymptomatic Testing and Screening

    Donna Shattuck Eidens;Melody Mcclure;Jacques Simard;Fernand Labrie

  • Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays

    J. G. Hacia;J.-B. Fan;O. Ryder;Li Jin;Li Jin

  • Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

    Lucio H. Castilla;Lucio H. Castilla;Fergus J. Couch;Michael R. Erdos;Kent F. Hoskins

  • The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1

    C. Oddoux;J. P. Struewing;C. M. Clayton;S. Neuhausen

  • Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

    Bassel Abou-Khalil;Pauls Auce;Andreja Avbersek;Melanie Bahlo

  • BRCA1 interacts with components of the histone deacetylase complex

    Ronit I. Yarden;Lawrence C. Brody

  • Maternal Vitamin B12 Status and Risk of Neural Tube Defects in a Population With High Neural Tube Defect Prevalence and No Folic Acid Fortification

    Anne M. Molloy;Peadar N. Kirke;James F. Troendle;Helen Burke

  • Prioritizing diversity in human genomics research.

    Lucia A Hindorff;Vence L Bonham;Lawrence C Brody;Margaret E C Ginoza

  • A Polymorphism, R653Q, in the Trifunctional Enzyme Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase/Formyltetrahydrofolate Synthetase Is a Maternal Genetic Risk Factor for Neural Tube Defects: Report of the Birth Defects Research Group

    Lawrence C. Brody;Mary Conley;Christopher Cox;Peadar N. Kirke

  • Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2

    Blanche P Alter;Philip S Rosenberg;Lawrence C Brody

  • Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies

    Richard Anney;A. Avbersek;D. Balding;L. Baum

  • The Prevalence of Common BRCA1 and BRCA2 Mutations among Ashkenazi Jews

    Patricia Hartge;Jeffery P. Struewing;Sholom Wacholder;Lawrence C. Brody

  • Strategic vision for improving human health at The Forefront of Genomics.

    Eric D. Green;Chris Gunter;Leslie G. Biesecker;Valentina Di Francesco

  • Breast cancer susceptibility genes. BRCA1 and BRCA2.

    Lawrence C. Brody;Barbara Bowles Biesecker

  • Human Germline Genome Editing

    Kelly E. Ormond;Douglas P. Mortlock;Derek T. Scholes;Yvonne Bombard

Frequent Co-Authors

James L. Mills
James L. Mills National Institutes of Health
Anne M. Molloy
Anne M. Molloy Trinity College Dublin
John M. Scott
John M. Scott Trinity College Dublin
Francis S. Collins
Francis S. Collins National Institutes of Health
Barry Shane
Barry Shane University of California, Berkeley
Christopher Cox
Christopher Cox Johns Hopkins University
Colleen M. McBride
Colleen M. McBride Emory University
Jeffery P. Struewing
Jeffery P. Struewing National Institutes of Health
Per Magne Ueland
Per Magne Ueland University of Bergen
Joan E. Bailey-Wilson
Joan E. Bailey-Wilson National Institutes of Health

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