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Biology and Biochemistry

D-Index
71
Citations
16398
World Ranking
6720
National Ranking
446

Overview

Kenji Sobue is affiliated with Iwate Medical University in Japan. Their research spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology. The primary subfields of study include cardiology and cardiovascular medicine, genetics, molecular biology, pulmonary and respiratory medicine, and epidemiology.

They have contributed to research topics such as genetic associations and epidemiology, inflammasome and immune disorders, gout, hyperuricemia, and uric acid, cardiovascular health and disease prevention, cerebrovascular and carotid artery diseases, acute myocardial infarction research, and liver disease diagnosis and treatment.

The scientist has published articles in various journals, including:

  • Journal of Epidemiology
  • Translational Psychiatry
  • Digestive Diseases and Sciences
  • International Journal of Environmental Research and Public Health
  • International Journal of Cardiology Cardiovascular Risk and Prevention

Recent publications include:

  • Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study, 2020, Journal of Epidemiology
  • Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes, 2020, Translational Psychiatry
  • NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis, 2021, Digestive Diseases and Sciences
  • Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population, 2021, International Journal of Environmental Research and Public Health
  • Epigenome-Wide Association Study Identifies a Novel DNA Methylation in Patients With Severe Aortic Valve Stenosis, 2020, Circulation Genomic and Precision Medicine

Kenji Sobue has collaborated frequently with several researchers, including:

  • Atsushi Shimizu
  • Makoto Sasaki
  • Mamoru Satoh
  • Hideki Ohmomo
  • Kozo Tanno

Their scientific output predominantly focuses on diseases and mechanisms related to cardiovascular and inflammatory conditions, with particular attention to genetic factors and molecular pathways underlying these disorders.

Best Publications

  • Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

    D Ilić;Y Furuta;S Kanazawa;N Takeda

  • The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1

    Nobutaka Hirokawa;Kenji Sobue;Keiko Kanda;Akihiro Harada

  • Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin.

    Kenji Sobue;Yoshihiko Muramoto;Masataka Fujita;Shiro Kakiuchi

  • Caldesmon, a novel regulatory protein in smooth muscle and nonmuscle actomyosin systems.

    K Sobue;J R Sellers

  • The Tohoku Medical Megabank Project: Design and Mission

    Shinichi Kuriyama;Nobuo Yaegashi;Fuji Nagami;Tomohiko Arai

  • Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling

    Tsuyoshi Morita;Taira Mayanagi;Kenji Sobue

  • Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation.

    Kenji Sobue;Ken’ichiro Hayashi;Wataru Nishida

  • Quantitative determinations of calmodulin in the supernatant and particulate fractions of mammalian tissues.

    Shiro Kakiuchi;Seiji Yasuda;Reiko Yamazaki;Yoshiko Teshima

  • Changes in the Balance of Phosphoinositide 3-Kinase/Protein Kinase B (Akt) and the Mitogen-activated Protein Kinases (ERK/p38MAPK) Determine a Phenotype of Visceral and Vascular Smooth Muscle Cells

    Ken'ichiro Hayashi;Masanori Takahashi;Kazuhiro Kimura;Wataru Nishida

  • Differential Control of Postsynaptic Density Scaffolds via Actin-Dependent and -Independent Mechanisms

    Toshihiko Kuriu;Akihiro Inoue;Haruhiko Bito;Kenji Sobue

  • Differentiated Phenotype of Smooth Muscle Cells Depends on Signaling Pathways through Insulin-like Growth Factors and Phosphatidylinositol 3-Kinase

    Ken'ichiro Hayashi;Hiroshi Saga;Yoshihiro Chimori;Kazuhiro Kimura

  • Determination of absolute protein numbers in single synapses by a GFP-based calibration technique.

    Yoshiko Sugiyama;Izumi Kawabata;Kenji Sobue;Shigeo Okabe

  • Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

    Ken’ichiro Hayashi;Masanori Takahashi;Wataru Nishida;Kenji Yoshida

  • Expression of high and low molecular weight caldesmons during phenotypic modulation of smooth muscle cells.

    Noboru Ueki;Kenji Sobue;Keiko Kanda;Toshikazu Hada

  • CONTROL OF ACTIN-MYOSIN INTERACTION OF GIZZARD SMOOTH MUSCLE BY CALMODULIN- AND CALDESMONLINKED FLIP-FLOP MECHANISM

    Kenji Sobue;Kouichi Morimoto;Makoto Inui;Keiko Kanda

  • Conformational change and localization of calpactin I complex involved in exocytosis as revealed by quick-freeze, deep-etch electron microscopy and immunocytochemistry.

    T Nakata;K Sobue;N Hirokawa

  • Occurrence of a Ca2+- and modulator protein-activatable ATPase in the synaptic plasma membranes of brain.

    Kenji Sobue;Seiji Ichida;Hiroshi Yoshida;Reiko Yamazaki

  • Occurrence of caldesmon (a calmodulin-binding protein) in cultured cells: comparison of normal and transformed cells.

    M K Owada;A Hakura;K Iida;I Yahara

  • Control of the cytoskeleton by calmodulin and calmodulin-binding proteins

    Shiro Kakiuchi;Kenji Sobue

  • Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering.

    Satoko Tadokoro;Taro Tachibana;Takanobu Imanaka;Wataru Nishida

Frequent Co-Authors

Ken-ichiro Hayashi
Ken-ichiro Hayashi Okayama University of Science
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Shigeo Okabe
Shigeo Okabe University of Tokyo
Yasuyuki Ohkawa
Yasuyuki Ohkawa Kyushu University
Junya Tanaka
Junya Tanaka Ehime University
Kengo Kinoshita
Kengo Kinoshita Tohoku University
Shigeo Kure
Shigeo Kure Tohoku University
Yasushi Fujio
Yasushi Fujio Osaka University
Yoshinori Nozawa
Yoshinori Nozawa Gifu University
Hiromi Fujiwara
Hiromi Fujiwara Osaka University

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