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Shigeo Kure

Shigeo Kure

D-Index & Metrics

Genetics

D-Index
69
Citations
17568
World Ranking
2347
National Ranking
89

Overview

Shigeo Kure is affiliated with Tohoku University in Japan and has a significant body of research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Genetics, Molecular Biology, Physiology, Pediatrics, Perinatology and Child Health, and Epidemiology.

The scientist's research topics cover Metabolism and Genetic Disorders, Genetics and Neurodevelopmental Disorders, Autism Spectrum Disorder Research, Genomic Variations and Chromosomal Abnormalities, Nutritional Studies and Diet, Neonatal Health and Biochemistry, as well as Genomics and Rare Diseases. This scope indicates a focus on the genetic and molecular basis of health conditions and developmental processes.

Among recent publications, notable papers include:

  • Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study, 2020, Journal of Epidemiology
  • Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference, 2021, Nature Communications
  • Clustering by phenotype and genome-wide association study in autism, 2020, Translational Psychiatry
  • A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes, 2021, Journal of Clinical Investigation
  • Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation, 2022, The Journal of Experimental Medicine

Shigeo Kure frequently publishes in venues such as The Tohoku Journal of Experimental Medicine, Molecular Genetics and Metabolism Reports, Brain and Development, Journal of Human Genetics, and bioRxiv (Cold Spring Harbor Laboratory). The consistency of publications in these journals highlights ongoing contributions to genetic and biomedical research.

Collaboration is an important aspect of their research, as evidenced by frequent co-authors including Shinichi Kuriyama, Atsuo Kikuchi, Junichi Sugawara, Atsushi Hozawa, and Tomohiro Nakamura. The partnerships with these researchers suggest a multidisciplinary approach within the related fields of study.

Best Publications

  • Germline mutations in HRAS proto-oncogene cause Costello syndrome

    Yoko Aoki;Tetsuya Niihori;Hiroshi Kawame;Kenji Kurosawa

  • A genome-wide association study identifies RNF213 as the first Moyamoya disease gene

    Fumiaki Kamada;Yoko Aoki;Ayumi Narisawa;Yu Abe

  • Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

    Tetsuya Niihori;Yoko Aoki;Yoko Narumi;Giovanni Neri

  • The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders.

    Yoko Aoki;Tetsuya Niihori;Yoko Narumi;Shigeo Kure

  • Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency

    Shigeo Kure;Dian Chang Hou;Toshihiro Ohura;Hiroko Iwamoto

  • Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals

    Masao Nagasaki;Jun Yasuda;Fumiki Katsuoka;Naoki Nariai

  • Glutamate triggers internucleosomal DNA cleavage in neuronal cells

    Shigeo Kure;Teiji Tominaga;Takashi Yoshimoto;Keiya Tada

  • The Tohoku Medical Megabank Project: Design and Mission

    Shinichi Kuriyama;Nobuo Yaegashi;Fuji Nagami;Tomohiko Arai

  • Homozygous c.14576G>A variant of RNF213 predicts early-onset and severe form of moyamoya disease.

    S. Miyatake;N. Miyake;H. Touho;A. Nishimura-Tadaki

  • Endonuclease activation following focal ischemic injury in the rat brain

    Teiji Tominaga;Shigeo Kure;Kuniaki Narisawa;Takashi Yoshimoto

  • Novel mutations in the connexin 26 gene (GJB2) responsible for childhood deafness in the Japanese population.

    Takayuki Kudo;Katsuhisa Ikeda;Shigeo Kure;Yoichi Matsubara

  • Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

    Koichi Kikuchi;Daisuke Saigusa;Yoshitomi Kanemitsu;Yotaro Matsumoto

  • Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness

    Takayuki Kudo;Shigeo Kure;Katsuhisa Ikeda;An Ping Xia

  • Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene.

    Miki Fujimura;Shinya Sonobe;Yasuo Nishijima;Kuniyasu Niizuma

  • Identification of polymorphisms in the promoter region of the human NRF2 gene

    Tae Yamamoto;Keigyou Yoh;Akira Kobayashi;Yukio Ishii

  • Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

    Tetsuya Niihori;Yoko Aoki;Hirofumi Ohashi;Kenji Kurosawa

  • Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.

    Tomoko Kobayashi;Yoko Aoki;Tetsuya Niihori;Hélène Cavé

  • Structure, turnover, and heme-mediated suppression of the level of mRNA encoding rat liver delta-aminolevulinate synthase.

    M Yamamoto;S Kure;J D Engel;K Hiraga

  • Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans

    Ayumi Narisawa;Shoko Komatsuzaki;Atsuo Kikuchi;Tetsuya Niihori

  • Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: A susceptibility gene for moyamoya disease

    Shinya Sonobe;Miki Fujimura;Kuniyasu Niizuma;Yasuo Nishijima

Frequent Co-Authors

Yoichi Matsubara
Yoichi Matsubara Tohoku University
Yoko Aoki
Yoko Aoki Tohoku University
Yoichi Suzuki
Yoichi Suzuki Chiba University
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Nobuo Yaegashi
Nobuo Yaegashi Tohoku University
Kengo Kinoshita
Kengo Kinoshita Tohoku University
Keiko Nakayama
Keiko Nakayama Tohoku University
Ichiro Tsuji
Ichiro Tsuji Tohoku University
Naomichi Matsumoto
Naomichi Matsumoto Yokohama City University
Hirofumi Ohashi
Hirofumi Ohashi Saitama Children's Medical Center

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