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Biology and Biochemistry
Argentina
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
10164
World Ranking
13980
National Ranking
9

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Argentina Leader Award
  • 2025 - Research.com Biology and Biochemistry in Argentina Leader Award
  • 2000 - Fellow, The World Academy of Sciences

Overview

Juan José Cazzulo is affiliated with the National University of General San Martín in Argentina. Their research spans primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on molecular biology, epidemiology, oncology, public health, environmental and occupational health, and cell biology.

The scientist's research topics concentrate on Trypanosoma species and their implications, peptidase inhibition and analysis, studies on leishmaniasis, cell death mechanisms and regulation, PARP inhibition in cancer therapy, endoplasmic reticulum stress and disease, as well as calcium signaling and nucleotide metabolism.

Key publications by Juan José Cazzulo include:

  • Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases, 2020, Molecular Cell
  • Update on relevant trypanosome peptidases: Validated targets and future challenges, 2020, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  • Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B, 2020, Bioorganic & Medicinal Chemistry Letters
  • Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity, 2020, Antimicrobial Agents and Chemotherapy

Frequent co-authors include:

  • Vanina E. Álvarez
  • Gabriela T. Niemirowicz
  • Elena A. Minina
  • Jens Staal
  • John A. Berges

Publications are regularly featured in scientific venues such as:

  • Molecular Cell
  • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  • Bioorganic & Medicinal Chemistry Letters
  • Antimicrobial Agents and Chemotherapy

Juan José Cazzulo received the fellowship of The World Academy of Sciences in 2000.

Best Publications

  • Aerobic fermentation of glucose by trypanosomatids.

    Juan José Cazzulo

  • End products and enzyme levels of aerobic glucose fermentation in trypanosomatids.

    Juan José Cazzulo;Berta M. Franke de Cazzulo;Juan Carlos Engel;Joaquin J.B. Cannata

  • The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is encoded by multiple polymorphic tandemly organized genes located on different chromosomes.

    O. Campetella;J. Henriksson;U. Åslund;A.C.C. Frasch

  • The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease.

    Juan Jose Cazzulo;Veronika Stoka;Vito Turk

  • Cysteine proteinase in Trypanosoma cruzi: immunocytochemical localization and involvement in parasite-host cell interaction

    Thais Souto-Padron;O. E. Campetella;J. J. Cazzulo;W. De Souza

  • Proteinases of Trypanosoma cruzi: patential targets for the chemotherapy of Changas desease.

    Juan José Cazzulo

  • Autophagy is involved in nutritional stress response and differentiation in Trypanosoma cruzi.

    Vanina E. Alvarez;Gregor Kosec;Celso Sant'Anna;Vito Turk

  • Further characterization and partial amino acid sequence of a cysteine proteinase from Trypanosoma cruzi.

    Juan Jose Cazzulo;Roberto Couso;Alejandra Raimondi;Christer Wernstedt

  • CRUZIPAIN, THE MAJOR CYSTEINE PROTEINASE FROM THE PROTOZOAN PARASITE TRYPANOSOMA CRUZI

    J J Cazzulo;V Stoka;V Turk

  • gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection.

    Ileana C. Cuevas;Juan J. Cazzulo;Daniel O. Sánchez

  • Intermediate metabolism in Trypanosoma cruzi.

    Juan José Cazzulo

  • Effects of proteinase inhibitors on the growth and differentiation of Trypanosoma cruzi

    Berta M. Franke de Cazzulo;Javier Martínez;Michael J. North;Graham H. Coombs

  • Trypanosoma cruzi calreticulin is a lectin that binds monoglucosylated oligosaccharides but not protein moieties of glycoproteins.

    Carlos Labriola;Juan J. Cazzulo;Armando J. Parodi

  • Metacaspases of Trypanosoma cruzi: possible candidates for programmed cell death mediators.

    Gregor Kosec;Vanina E. Alvarez;Fernán Agüero;Daniel Sánchez

  • SAPA/trans-sialidase and cruzipain: two antigens from Trypanosoma cruzi contain immunodominant but enzymatically inactive domains.

    Juan J. Cazzulo;Alberto C. C. Frasch

  • Chromosome specific markers reveal conserved linkage groups in spite of extensive chromosomal size variation in Trypanosoma cruzi

    Jan Henriksson;Betina Porcel;Maria Rydåker;Andres Ruiz

  • Subcellular localization of a cysteine proteinase from Trypanosoma cruzi.

    Esteban Bontempi;Javier Martinez;Juan José Cazzulo

  • Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily

    Veronika Stoka;Maria Nycander;Brigita Lenarčič;Carlos Labriola

  • Chromosomal localization of seven cloned antigen genes provides evidence of diploidy and further demonstration of karyotype variability in Trypanosoma cruzi.

    Jan Henriksson;Lena Åslund;Roberto A. Macina;Berta M. Franke de Cazzulo

  • The C-terminal extension of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi.

    L. Åslund;J. Henriksson;O. Campetella;A.C.C. Frasch

Frequent Co-Authors

Ulf Hellman
Ulf Hellman Ludwig Cancer Research
Alberto C.C. Frasch
Alberto C.C. Frasch National University of General San Martín
Vito Turk
Vito Turk Jožef Stefan Institute
Ulf Pettersson
Ulf Pettersson Uppsala University
Michael P. Barrett
Michael P. Barrett University of Glasgow
Christer Wernstedt
Christer Wernstedt Ludwig Cancer Research
Boris Turk
Boris Turk Jožef Stefan Institute
Roberto Docampo
Roberto Docampo University of Georgia
Mercedes González
Mercedes González University of the Republic
Estela M. Valle
Estela M. Valle Consejo Nacional de Investigaciones Científicas y Técnicas

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