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Jean-Claude Lacaille

Jean-Claude Lacaille

D-Index & Metrics

Neuroscience

D-Index
69
Citations
15043
World Ranking
2662
National Ranking
153

Research.com Recognitions

  • 1988 - Fellow of Alfred P. Sloan Foundation

Overview

Jean-Claude Lacaille is affiliated with the University of Montreal in Canada and has contributed extensively to the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology. Their research spans multiple specialized areas including Cellular and Molecular Neuroscience, Molecular Biology, Cognitive Neuroscience, Physiology, and Neurology.

The scientist's main research topics cover a range of subjects related to neural function and disorders: Neuroscience and Neuropharmacology Research, Memory and Neural Mechanisms, Receptor Mechanisms and Signaling, Neuroinflammation and Neurodegeneration Mechanisms, Genetics and Neurodevelopmental Disorders, Photoreceptor and Optogenetics Research, and Retinal Development and Disorders.

Jean-Claude Lacaille has published numerous papers in various academic journals. Notable recent papers include:

  • "eIF2α controls memory consolidation via excitatory and somatostatin neurons" (2020, Nature)
  • "Antidepressant actions of ketamine engage cell-specific translation via eIF4E" (2020, Nature)
  • "Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory" (2021, Frontiers in Neural Circuits)
  • "Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice" (2020, Molecular Autism)
  • "Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders" (2021, Molecular Psychiatry)

Their frequent publication venues include:

  • Molecular Brain
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Nature
  • Molecular Autism

Jean-Claude Lacaille has collaborated extensively with other researchers, with frequent coauthors including Nahum Sonenberg, Argel Aguilar-Valles, Isabel Laplante, Arkady Khoutorsky, and Ève Honoré.

In recognition of their scientific contributions, the scientist was named a Fellow of the Alfred P. Sloan Foundation in 1988.

Best Publications

  • Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

    Aude Panatier;Joanne Vallée;Michael Haber;Keith K. Murai

  • Autism-related deficits via dysregulated eIF4E-dependent translational control

    Christos G. Gkogkas;Arkady Khoutorsky;Israeli Ran;Emmanouil Rampakakis

  • eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory

    Mauro Costa-Mattioli;Delphine Gobert;Elad Stern;Karine Gamache

  • Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase, GCN2

    Mauro Costa-Mattioli;Delphine Gobert;Heather Harding;Barbara Herdy

  • Local circuit interactions between oriens/alveus interneurons and CA1 pyramidal cells in hippocampal slices: electrophysiology and morphology.

    J. C. Lacaille;A. L. Mueller;D. D. Kunkel;Philip A Schwartzkroin

  • GABAergic Network Activation of Glial Cells Underlies Hippocampal Heterosynaptic Depression

    Alexandre Serrano;Nasser Haddjeri;Jean-Claude Lacaille;Richard Robitaille

  • Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation.

    Fadi F. Hamdan;Julie Gauthier;Dan Spiegelman;Anne Noreau

  • Excess of De Novo Deleterious Mutations in Genes Associated with Glutamatergic Systems in Nonsyndromic Intellectual Disability

    Fadi F. Hamdan;Julie Gauthier;Yoichi Araki;Da-Ting Lin

  • Characterization of an RNA Granule from Developing Brain

    George Elvira;Sylwia Wasiak;Vanessa Blandford;Xin-Kang Tong

  • Mutations in SYNGAP1 Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency

    Martin H. Berryer;Fadi F. Hamdan;Laura L. Klitten;Rikke S. Møller

  • Stratum lacunosum-moleculare interneurons of hippocampal CA1 region. II. Intrasomatic and intradendritic recordings of local circuit synaptic interactions.

    J. C. Lacaille;Philip A Schwartzkroin

  • Stratum lacunosum-moleculare interneurons of hippocampal CA1 region. I. Intracellular response characteristics, synaptic responses, and morphology

    J. C. Lacaille;Philip A Schwartzkroin

  • De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment

    Fadi F. Hamdan;Hussein Daoud;Daniel Rochefort;Amélie Piton

  • Interneuron Diversity series: Hippocampal interneuron classifications – making things as simple as possible, not simpler

    Gianmaria Maccaferri;Jean Claude Lacaille

  • Metformin ameliorates core deficits in a mouse model of fragile X syndrome

    Ilse Gantois;Arkady Khoutorsky;Jelena Popic;Argel Aguilar-Valles

  • A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons

    Yaël Perez;Jean-Claude Lacaille

  • De novo SYNGAP1 mutations in nonsyndromic intellectual disability and autism.

    Fadi F. Hamdan;Hussein Daoud;Amélie Piton;Julie Gauthier

  • Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

    Christos G. Gkogkas;Arkady Khoutorsky;Ruifeng Cao;Seyed Mehdi Jafarnejad

  • Reactivation of stalled polyribosomes in synaptic plasticity

    Tyson E. Graber;Sarah Hébert-Seropian;Arkady Khoutorsky;Alexandre David

  • Axonal sprouting of CA1 pyramidal cells in hyperexcitable hippocampal slices of kainate-treated rats.

    Yael Perez;Clermont Beaulieu;Jean Claude Lacaille

  • Ultrastructure of stratum lacunosum moleculare interneurons of hippocampal CA1 region

    Dennis D. Kunkel;Jean‐Claude Lacaille;Philip A. Schwartzkroin

  • Intrinsic Theta-Frequency Membrane Potential Oscillations in Hippocampal CA1 Interneurons of Stratum Lacunosum-Moleculare

    C. Andrew Chapman;Jean-Claude Lacaille

Frequent Co-Authors

Fadi F. Hamdan
Fadi F. Hamdan University of Montreal
Guy A. Rouleau
Guy A. Rouleau Montreal Neurological Institute and Hospital
Jacques L. Michaud
Jacques L. Michaud University of Montreal
Richard Robitaille
Richard Robitaille University of Montreal
Karim Nader
Karim Nader McGill University
Philip A. Schwartzkroin
Philip A. Schwartzkroin University of California, Davis
Lionel Carmant
Lionel Carmant University of Montreal
Pierre Drapeau
Pierre Drapeau University of Montreal
Laurent Mottron
Laurent Mottron University of Montreal
Sylvain Williams
Sylvain Williams McGill University

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