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Ignaty Leshchiner

Ignaty Leshchiner

D-Index & Metrics

Molecular Biology

D-Index
48
Citations
24562
World Ranking
2653
National Ranking
1292

Overview

Ignaty Leshchiner is affiliated with the Broad Institute in the United States and focuses on research primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans multiple subfields, including Cancer Research, Molecular Biology, Genetics, Pulmonary and Respiratory Medicine, and Oncology.

The main research topics covered by Leshchiner include:

  • Cancer Genomics and Diagnostics
  • Chronic Lymphocytic Leukemia Research
  • Genetic factors in colorectal cancer
  • Cancer Immunotherapy and Biomarkers
  • Lung Cancer Treatments and Mutations
  • Pancreatic and Hepatic Oncology Research
  • Advanced Breast Cancer Therapies

Leshchiner has published research in numerous venues, with frequent contributions to:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Nature Communications
  • Journal of Clinical Oncology

Some of the notable recent papers include:

  • The evolutionary history of 2,658 cancers, 2020, Nature
  • Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes, 2021, Cell
  • Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer, 2021, Cancer Discovery
  • Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression, 2020, Journal of Clinical Oncology
  • Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer, 2023, Nature Genetics

Frequent collaborators in their research include:

  • Gad Getz
  • Dimitri Livitz
  • Brian P. Danysh
  • Chip Stewart
  • Laxmi Parida

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • The Molecular Taxonomy of Primary Prostate Cancer

    Adam Abeshouse;Jaeil Ahn;Rehan Akbani;Adrian Ally

  • Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

    Benjamin J. Raphael;Ralph H. Hruban;Andrew J. Aguirre;Richard A. Moffitt

  • Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

    Bjoern Chapuy;Chip Stewart;Andrew J Dunford;Jaegil Kim

  • Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer

    Justin F. Gainor;Leila Dardaei;Satoshi Yoda;Luc Friboulet

  • The evolutionary history of 2,658 cancers

    Moritz Gerstung;Moritz Gerstung;Clemency Jolly;Ignaty Leshchiner;Stefan C Dentro;Stefan C Dentro;Stefan C Dentro

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

    Viktor A. Adalsteinsson;Viktor A. Adalsteinsson;Gavin Ha;Gavin Ha;Samuel S. Freeman;Samuel S. Freeman;Atish D. Choudhury

  • Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

    Lauren Fishbein;Lauren Fishbein;Ignaty Leshchiner;Ignaty Leshchiner;Vonn Walter;Vonn Walter;Ludmila Danilova;Ludmila Danilova

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

    Stefan C. Dentro;Stefan C. Dentro;Stefan C. Dentro;Ignaty Leshchiner;Kerstin Haase;Maxime Tarabichi;Maxime Tarabichi

  • Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F.

    Shaw At;Friboulet L;Leshchiner I;Gainor Jf

  • A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

    Paz Polak;Jaegil Kim;Lior Z Braunstein;Lior Z Braunstein;Rosa Karlic

  • Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.

    Lipika Goyal;Supriya K. Saha;Leah Y. Liu;Giulia Siravegna

  • An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

    Catherine A. Brownstein;Alan H. Beggs;Nils Homer;Barry Merriman

  • Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

    Aparna R Parikh;Ignaty Leshchiner;Liudmila Elagina;Lipika Goyal

  • Integrated Molecular Characterization of Uterine Carcinosarcoma

    Andrew D. Cherniack;Hui Shen;Vonn Walter;Chip Stewart

  • Paired exome analysis of Barrett's esophagus and adenocarcinoma.

    Matthew D Stachler;Matthew D Stachler;Amaro Taylor-Weiner;Shouyong Peng;Aaron McKenna

  • Molecular mechanisms of resistance to first- and second-generation ALK inhibitors in ALK-rearranged lung cancer

    J. Gainor;L. Dardaei;S. Yoda;L. Friboulet

  • The Molecular Taxonomy of Primary Prostate Cancer

    Adam Abeshouse;Jaeil Ahn;Rehan Akbani;Adrian Ally

Frequent Co-Authors

Gad Getz
Gad Getz Broad Institute
Rameen Beroukhim
Rameen Beroukhim Harvard University
Catherine J. Wu
Catherine J. Wu Harvard University
Chip Stewart
Chip Stewart Broad Institute
Jennifer R. Brown
Jennifer R. Brown Harvard University
Todd R. Golub
Todd R. Golub Harvard University
Michael S. Lawrence
Michael S. Lawrence Harvard University
Matthew Meyerson
Matthew Meyerson Harvard University
Donna Neuberg
Donna Neuberg Harvard University
Paul C. Boutros
Paul C. Boutros University of California, Los Angeles

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