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Ian A. Cotgreave

Ian A. Cotgreave

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
11252
World Ranking
10438
National Ranking
150

Overview

Ian A. Cotgreave is affiliated with the Karolinska Institute in Sweden, contributing to research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, including Molecular Biology, Health, Toxicology and Mutagenesis, Small Animals, Neurology, and Computational Theory and Mathematics.

The scientist has published on various topics, with a focus on Computational Drug Discovery Methods, Acute Ischemic Stroke Management, Animal testing and alternatives, Toxic Organic Pollutants Impact, Air Quality and Health Impacts, Chemical Synthesis and Analysis, and the Effects and risks of endocrine disrupting chemicals.

Recent papers authored by or involving Ian A. Cotgreave include:

  • Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment, 2023, JAMA Neurology
  • Assessing exposure of semi-volatile organic compounds (SVOCs) in car cabins: Current understanding and future challenges in developing a standardized methodology, 2021, Environment International
  • 3R-Refinement principles: elevating rodent well-being and research quality, 2024, Laboratory Animal Research
  • APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke, 2023, Frontiers in Neurology
  • hERG-toxicity prediction using traditional machine learning and advanced deep learning techniques, 2023, Current Research in Toxicology

Ian A. Cotgreave frequently collaborates with other researchers. Notable co-authors include Ulf Norinder, Swapnil Chavan, Macarena Hernández-Jiménez, Francisco Abad-Santos, and Jaime Gállego.

Publications by this scientist appear across several scientific journals with repeated contributions to:

  • Current Research in Toxicology
  • JAMA Neurology
  • Laboratory Animal Research
  • Environment International
  • Frontiers in Neurology

Best Publications

  • Recent Trends in Glutathione Biochemistry—Glutathione–Protein Interactions: A Molecular Link between Oxidative Stress and Cell Proliferation?

    Ian A Cotgreave;Robert G Gerdes

  • N-acetylcysteine: pharmacological considerations and experimental and clinical applications.

    Ian A. Cotgreave

  • Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody.

    Diels J. van den Dobbelsteen;C. Stefan I. Nobel;Jörg Schlegel;Ian A. Cotgreave

  • Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis.

    Christina Lind;Robert Gerdes;Ylva Hamnell;Ina Schuppe-Koistinen

  • Lung protection by a thiol-containing antioxidant: N-acetylcysteine.

    Peter Moldéus;Ian A. Cotgreave;Margareta Berggren

  • Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems

    Ian A. Cotgreave;Peter Moldéus

  • Host Biochemical Defense Mechanisms Against Prooxidants

    Cotgreave Ia;Moldéus P;Orrenius S

  • Thiol peroxidase activity of diaryl ditellurides as determined by a proton NMR method

    Lars Engman;David Stern;Ian A. Cotgreave;Carl M. Andersson

  • Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA

    Tim Hofer;Carine Badouard;Edyta Bajak;Jean-Luc Ravanat

  • Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli

    Afshin Samali;John D. Robertson;Elisabeth Peterson;Florence Manero

  • S-Thiolation of human endothelial cell glyceraldehyde-3-phosphate dehydrogenase after hydrogen peroxide treatment

    Ina Schuppe‐Koistinen;Peter Moldéus;Tomas Bergman;Ian A. Cotgreave

  • Strategic Focus on 3R Principles Reveals Major Reductions in the Use of Animals in Pharmaceutical Toxicity Testing

    Elin Törnqvist;Anita Annas;Britta Granath;Elisabeth Jalkesten

  • Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth.

    Michael McNaughton;Lars Engman;Anne Birmingham;Garth Powis

  • Skeletal muscle glutathione is depleted in critically ill patients.

    Folke Hammarqvist;Jia-Li Luo;Ian A. Cotgreave;Kerstin Andersson

  • Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?

    Ian A. Cotgreave;Steven K. Duddy;George E.N. Kass;David Thompson

  • The antioxidant profile of 2,3-dihydrobenzo[b]furan-5-ol and its 1-thio, 1-seleno, and 1-telluro analogues.

    Jonas Malmström;Mats Jonsson;Ian A. Cotgreave;Leif Hammarström

  • Studies on the mechanism of oxidative modification of human glyceraldehyde-3-phosphate dehydrogenase by glutathione: catalysis by glutaredoxin.

    Christina Lind;Robert Gerdes;Ina Schuppe-Koistinen;Ian A. Cotgreave

  • [48] N-acetylcysteine

    Peter Moldéus;Ian A. Cotgreave

  • Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells

    Therese Söderdahl;Mari Enoksson;Mathias Lundberg;Arne Holmgren

  • Diaryl chalcogenides as selective inhibitors of thioredoxin reductase and potential antitumor agents.

    Lars Engman;Ian Cotgreave;Miguel Angulo;Charles W. Taylor

Frequent Co-Authors

Peter Moldéus
Peter Moldéus Karolinska Institute
Lars Engman
Lars Engman Uppsala University
Sten Orrenius
Sten Orrenius Karolinska Institute
Roland C. Grafström
Roland C. Grafström Karolinska Institute
Ralf Morgenstern
Ralf Morgenstern Karolinska Institute
Anders Hallberg
Anders Hallberg Uppsala University
Arne Holmgren
Arne Holmgren Karolinska Institute
Tommy B. Andersson
Tommy B. Andersson AstraZeneca (United Kingdom)
Sidney D. Nelson
Sidney D. Nelson University of Washington
Tomas Bergman
Tomas Bergman Karolinska Institute

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