Hugh Paterson

Overview

Best Publications

• Mutations of the BRAF gene in human cancer

  Helen Davies;Graham R. Bignell;Charles Cox;Philip Stephens

  12683
  Citations

• The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

  Anne J. Ridley;Hugh F. Paterson;Caroline L. Johnston;Dagmar Diekmann

  5666
  Citations

• Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

  Sally Cowley;Hugh Paterson;Pauline Kemp;Christopher J. Marshall

  2520
  Citations

• Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

  Sally J. Leevers;Hugh F. Paterson;Christopher J. Marshall

  1475
  Citations

• A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

  John F. Hancock;Hugh Paterson;Christopher J. Marshall

  1422
  Citations

• Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor.

  S Traverse;N Gomez;H Paterson;C Marshall

  1297
  Citations

• Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

  Victoria Sanz-Moreno;Gilles Gadea;Jessica Ahn;Hugh Paterson

  1118
  Citations

• Microinjection of recombinant p21rho induces rapid changes in cell morphology.

  H F Paterson;A J Self;M D Garrett;I Just

  908
  Citations

• Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

  R Marais;Y Light;H F Paterson;C J Marshall

  850
  Citations

• The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

  Timothy E. Allsopp;Sean Wyatt;Hugh F. Paterson;Alun M. Davies

  820
  Citations

• EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor.

  Sarah Traverse;Klaus Seedorf;Hugh Paterson;Chris J. Marshall

  673
  Citations

• A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins

  John F. Hancock;Karen Cadwallader;Hugh Paterson;Christopher J. Marshall

  669
  Citations

• Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

  Richard Marais;Yvonne Light;Hugh F. Paterson;Clive S. Mason

  622
  Citations

• Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

  Michael F. Olson;Hugh F. Paterson;Christopher J. Marshall

  618
  Citations

• Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

  Richard Marais;Yvonne Light;Clive Mason;Hugh Paterson

  540
  Citations

• Intracellular localization of the P21rho proteins.

  P Adamson;H F Paterson;A Hall

  537
  Citations

• Wild-Type and Mutant B-RAF Activate C-RAF through Distinct Mechanisms Involving Heterodimerization

  Mathew J. Garnett;Sareena Rana;Hugh Paterson;David Barford

  495
  Citations

• Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

  Rachel Ben-Levy;Steven Hooper;Rebecca Wilson;Hugh F. Paterson

  489
  Citations

• Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion.

  Simon Wilkinson;Hugh F Paterson;Christopher J Marshall

  447
  Citations

• Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

  Andrew Tutt;Anastasia Gabriel;David Bertwistle;Frances Connor

  434
  Citations