What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Signal transduction
His scientific interests lie mostly in Cell biology, Signal transduction, Epidermal growth factor, Growth factor and Kinase.
His Cell biology study combines topics from a wide range of disciplines, such as Biochemistry and Membrane ruffling.
His research investigates the connection with Membrane ruffling and areas like Endogeny which intersect with concerns in Rac GTP-Binding Proteins, Microinjection and RAC1.
His Signal transduction research incorporates themes from Cell cycle, Cell growth and Intracellular.
Hugh Paterson has researched Epidermal growth factor in several fields, including Mitogen-activated protein kinase and Kinase activity.
He interconnects Endocrinology and Nerve growth factor in the investigation of issues within Growth factor.
His most cited work include:
- Mutations of the BRAF gene in human cancer (8013 citations)
- The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. (2739 citations)
- Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells (1851 citations)
What are the main themes of his work throughout his whole career to date?
Hugh Paterson mainly investigates Cell biology, Signal transduction, Molecular biology, Kinase and Biochemistry.
His Cell biology research focuses on GTPase in particular.
His work carried out in the field of Signal transduction brings together such families of science as Epidermal growth factor and Phosphorylation.
His study explores the link between Molecular biology and topics such as Fibroblast that cross with problems in Transformation.
In general Biochemistry, his work in Cell membrane, Subcellular localization and Endoplasmic reticulum is often linked to Palmitoylation linking many areas of study.
His Kinase activity study often links to related topics such as c-Raf.
He most often published in these fields:
- Cell biology (69.44%)
- Signal transduction (26.39%)
- Molecular biology (25.00%)
What were the highlights of his more recent work (between 2003-2015)?
- Cell biology (69.44%)
- Signal transduction (26.39%)
- Cancer research (9.72%)
In recent papers he was focusing on the following fields of study:
Hugh Paterson focuses on Cell biology, Signal transduction, Cancer research, Phosphorylation and Cell cycle.
His Cell biology study combines topics in areas such as Carcinogenesis, Cancer cell and Angiogenesis.
He combines subjects such as Microphthalmia-associated transcription factor, Melanocyte differentiation, Transcription factor, DNA and Cyclin-dependent kinase 2 with his study of Cancer research.
The various areas that Hugh Paterson examines in his Phosphorylation study include Contractility, Kinase and Myosin.
His biological study spans a wide range of topics, including Melanoma and MAPK/ERK pathway.
His Protein kinase A study integrates concerns from other disciplines, such as Wild type, Mutant, Cell signaling and Kinase activity.
Between 2003 and 2015, his most popular works were:
- Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement (743 citations)
- Wild-Type and Mutant B-RAF Activate C-RAF through Distinct Mechanisms Involving Heterodimerization (327 citations)
- Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. (314 citations)
In his most recent research, the most cited papers focused on:
Hugh Paterson mostly deals with Cell biology, Signal transduction, Phosphorylation, Kinase and GTPase.
His Cell biology study frequently links to other fields, such as Programmed cell death.
His study looks at the intersection of Programmed cell death and topics like Cell cycle with Rho-associated protein kinase.
His work on Guanine nucleotide exchange factor as part of general GTPase research is frequently linked to Arp2/3 complex, thereby connecting diverse disciplines of science.
The concepts of his Myosin study are interwoven with issues in CDC42, Contractility and Cytoskeleton.
His c-Raf research includes elements of Wild type, Mutant, Cell signaling and Kinase activity.
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