Hiroyasu Inoue

What is he best known for?

The fields of study he is best known for:

• Gene
• Enzyme
• DNA

Molecular biology, Messenger RNA, Cancer research, Receptor and Cyclooxygenase are his primary areas of study. His Molecular biology study combines topics in areas such as Prostaglandin E2, Biochemistry, Transfection and Prostacyclin synthase. He combines subjects such as U937 cell, Gene expression, Transcriptional regulation, Cyclic AMP Response Element and Response element with his study of Messenger RNA.

His study looks at the relationship between Cyclic AMP Response Element and fields such as Transcription, as well as how they intersect with chemical problems. His Angiogenesis study, which is part of a larger body of work in Cancer research, is frequently linked to IκBα, bridging the gap between disciplines. He interconnects Inflammation, Nuclear receptor, Endocrinology and Resveratrol in the investigation of issues within Receptor.

His most cited work include:

• Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells (700 citations)
• Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element (464 citations)
• The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. (398 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Molecular biology, Internal medicine, Endocrinology, Biochemistry and Cyclooxygenase. The various areas that Hiroyasu Inoue examines in his Molecular biology study include Messenger RNA, Gene, Transfection, Response element and Isozyme. In his study, Apoptosis, Endothelial stem cell and Cell culture is strongly linked to Cell biology, which falls under the umbrella field of Transfection.

His Endocrinology research is multidisciplinary, relying on both Gene expression, Downregulation and upregulation, Receptor, Signal transduction and Regulation of gene expression. His Peptide sequence, Activator, Amino acid and Lipid metabolism study in the realm of Biochemistry interacts with subjects such as PKM2. The concepts of his Cyclooxygenase study are interwoven with issues in Prostaglandin E2, Prostaglandin, Northern blot and Prostacyclin.

He most often published in these fields:

• Molecular biology (35.07%)
• Internal medicine (28.36%)
• Endocrinology (27.61%)

What were the highlights of his more recent work (between 2011-2019)?

• Peroxisome proliferator-activated receptor (16.42%)
• Biochemistry (26.12%)
• Internal medicine (28.36%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Peroxisome proliferator-activated receptor, Biochemistry, Internal medicine, Endocrinology and Lipid metabolism. His Peroxisome proliferator-activated receptor research incorporates themes from Beta oxidation and Resveratrol. The study incorporates disciplines such as Sirtuin 1 and Cell biology in addition to Resveratrol.

His studies deal with areas such as Molecular biology, DNA microarray and Gene as well as Cell biology. In general Biochemistry, his work in Peroxisome, Activator and Metabolic enzymes is often linked to Gamma-glutamyl hydrolase linking many areas of study. When carried out as part of a general Internal medicine research project, his work on Receptor, Adipose tissue, Insulin resistance and Postprandial is frequently linked to work in FGF21, therefore connecting diverse disciplines of study.

Between 2011 and 2019, his most popular works were:

• Recent advances in the study on resveratrol. (121 citations)
• Up-regulation of endothelial nitric oxide synthase ( eNOS ), silent mating type information regulation 2 homologue 1 ( SIRT1 ) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells (30 citations)
• DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells (30 citations)

In his most recent research, the most cited papers focused on:

• Gene
• Enzyme
• DNA

His main research concerns Peroxisome proliferator-activated receptor, Internal medicine, Endocrinology, Resveratrol and Pharmacology. The Internal medicine study combines topics in areas such as Beta oxidation and Hepatocyte. Endocrinology is often connected to Intestinal mucosa in his work.

Resveratrol is a subfield of Biochemistry that he explores. The study incorporates disciplines such as AMPK, Type 2 diabetes and In vivo in addition to Receptor. Hiroyasu Inoue regularly links together related areas like Cyclooxygenase in his Phytoalexin studies.