World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
10843
World Ranking
16104
National Ranking
1148

Overview

Koichi Kokame is affiliated with the National Cerebral and Cardiovascular Center in Japan. Their research primarily spans the fields of medicine and biochemistry, genetics, and molecular biology, with a particular focus on hematology, genetics, immunology, cell biology, and cardiology and cardiovascular medicine.

The scientist's work covers several main topics, including:

  • Complement system in diseases
  • Platelet disorders and treatments
  • Blood coagulation and thrombosis mechanisms
  • Coagulation, bradykinin, polyphosphates, and angioedema
  • Blood groups and transfusion
  • Cellular transport and secretion
  • Erythrocyte function and pathophysiology

Koichi Kokame has contributed to various academic journals, with frequent publications in:

  • Research and Practice in Thrombosis and Haemostasis
  • Japanese Journal of Thrombosis and Hemostasis
  • Journal of Thrombosis and Haemostasis
  • Blood Advances
  • bioRxiv (Cold Spring Harbor Laboratory)

Significant recent papers include:

  • Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) in Japan 2023, published in International Journal of Hematology (2023)
  • Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress, published in International Journal of Molecular Sciences (2020)
  • Success and limitations of plasma treatment in pregnant women with congenital thrombotic thrombocytopenic purpura, published in Journal of Thrombosis and Haemostasis (2020)
  • Current prophylactic plasma infusion protocols do not adequately prevent long-term cumulative organ damage in the Japanese congenital thrombotic thrombocytopenic purpura cohort, published in British Journal of Haematology (2021)
  • von Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis, published in Research and Practice in Thrombosis and Haemostasis (2023)

Koichi Kokame collaborates regularly with several researchers, including:

  • Masanori Matsumoto
  • Yuka Eura
  • Toshiyuki Miyata
  • Keiko Maruyama
  • Kazuya Sakai

Best Publications

  • FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay.

    Koichi Kokame;Yuko Nobe;Yoshihiro Kokubo;Akira Okayama

  • Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes

    Koichi Kokame;Hisao Kato;Toshiyuki Miyata

  • Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis -Acting Elements ERSE, UPRE and ERSE-II

    Keisuke Yamamoto;Hiderou Yoshida;Hiderou Yoshida;Koichi Kokame;Randal J. Kaufman

  • Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity

    Koichi Kokame;Masanori Matsumoto;Kenji Soejima;Hideo Yagi

  • Herp, a New Ubiquitin-like Membrane Protein Induced by Endoplasmic Reticulum Stress

    Koichi Kokame;Kishan Lal Agarwala;Hisao Kato;Toshiyuki Miyata

  • Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts

    Tsuyoshi Hirota;Toshiyuki Okano;Koichi Kokame;Hiroko Shirotani-Ikejima

  • Identification of ERSE-II, a New cis-Acting Element Responsible for the ATF6-dependent Mammalian Unfolded Protein Response

    Koichi Kokame;Hisao Kato;Toshiyuki Miyata

  • Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus.

    Yukari Date;Takuya Shimbara;Shuichi Koda;Koji Toshinai

  • Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.

    Rui-Hai Zhou;Koichi Kokame;Yoshitane Tsukamoto;Chikao Yutani

  • Lipid modification at the N terminus of photoreceptor G-protein α-subunit

    Koichi Kokame;Yoshitaka Fukada;Tôru Yoshizawa;Toshifumi Takao

  • Evolution of the androgen receptor pathway during progression of prostate cancer.

    Peter J.M. Hendriksen;Natasja F.J. Dits;Koichi Kokame;Antoine Veldhoven

  • Natural history of Upshaw-Schulman syndrome based on ADAMTS13 gene analysis in Japan.

    Y. Fujimura;M. Matsumoto;A. Isonishi;H. Yagi

  • ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage.

    Kenji Soejima;Masanori Matsumoto;Koichi Kokame;Hideo Yagi

  • VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13.

    Koichi Kokame;Masanori Matsumoto;Yoshihiro Fujimura;Toshiyuki Miyata

  • Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura

    Fumiaki Banno;Koichi Kokame;Tomohiko Okuda;Shigenori Honda

  • Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome

    Masanori Matsumoto;Koichi Kokame;Kenji Soejima;Masayoshi Miura

  • Pregnancy‐induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw–Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients

    Yoshihiro Fujimura;Masanori Matsumoto;Koichi Kokame;Ayami Isonishi

  • Ndrg1-Deficient Mice Exhibit a Progressive Demyelinating Disorder of Peripheral Nerves

    Tomohiko Okuda;Yujiro Higashi;Koichi Kokame;Chihiro Tanaka

  • Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor

    Masashi Akiyama;Soichi Takeda;Koichi Kokame;Junichi Takagi

  • Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element

    Genqing Liang;Timothy E. Audas;Yu Li;Gregory P. Cockram

Frequent Co-Authors

Toshiyuki Miyata
Toshiyuki Miyata Kyushu University
Masashi Akiyama
Masashi Akiyama Nagoya University
Yuzuru Kanakura
Yuzuru Kanakura Osaka University
Bernhard Lämmle
Bernhard Lämmle University of Bern
Masaomi Nangaku
Masaomi Nangaku University of Tokyo
Kenji Kangawa
Kenji Kangawa National Cerebral and Cardiovascular Center
Yasuo Ikeda
Yasuo Ikeda Waseda University
Yoshitaka Fukada
Yoshitaka Fukada University of Tokyo
Sergio Lavandero
Sergio Lavandero University of Chile
Michihiro Fujiwara
Michihiro Fujiwara Fukuoka University

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