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Biology and Biochemistry

D-Index
79
Citations
21504
World Ranking
4334
National Ranking
2110

Overview

Frederick Sachs was a researcher affiliated with the University at Buffalo, State University of New York, in the United States. Their work spanned multiple fields primarily within medicine and biochemistry, genetics, and molecular biology. The scientist contributed to a range of topics focused on cellular and physiological processes, with particular emphasis on erythrocyte function, cellular mechanics, blood properties, and neurovascular conditions.

Their research addressed key subjects including:

  • Erythrocyte Function and Pathophysiology
  • Cellular Mechanics and Interactions
  • Blood Properties and Coagulation
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Rheology and Fluid Dynamics Studies
  • Ion Channel Regulation and Function
  • Traumatic Brain Injury Research

Frederick Sachs published across several prominent scientific venues, involving multiple papers in specialized journals. Frequent places of publication included:

  • Biophysical Journal
  • Scientific Reports
  • Brain Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of Advanced Biomedical Sciences

Notable recent papers authored or coauthored by Frederick Sachs included:

  • "Adherent cell remodeling on micropatterns is modulated by Piezo1 channels," 2021, Scientific Reports
  • "Effects of membrane viscoelasticity on the red blood cell dynamics in a microcapillary," 2023, Biophysical Journal
  • "Physical memory of astrocytes," 2022, Brain Research
  • "Adherent cell remodeling on micropatterns is modulated by Piezo1 channels," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Hall Effect Sensor for Animal Geomagnetic Navigation," 2021, Annals of Advanced Biomedical Sciences

Throughout their career, Frederick Sachs collaborated frequently with several researchers, including:

  • Susan Z. Hua
  • Deekshitha Jetta
  • Mohammad Reza Bahrani Fard
  • Katie Munechika
  • Tasnim Shireen

Their subfields of study reflected a multidisciplinary approach, incorporating aspects of cell biology, physiology, molecular biology, pulmonary and respiratory medicine, and neurology. This scope underscored a focus on both fundamental cellular processes and clinical-relevant conditions.

Frederick Sachs contributed primarily to advancing knowledge in cell mechanics and blood-related pathophysiology. Their published work explored mechanisms such as ion channel regulation, mechanical properties of cells, and interactions influencing red blood cell dynamics and neurovascular health.

Best Publications

  • Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle.

    F Guharay;F Sachs

  • Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions.

    Xian Cheng Yang;Frederick Sachs

  • Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.

    Whasil Lee;Holly A. Leddy;Yong Chen;Suk Hee Lee

  • Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL

    Sergei I. Sukharev;Wade J. Sigurdson;Ching Kung;Frederick Sachs

  • The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4.

    Chilman Bae;Frederick Sachs;Philip A. Gottlieb

  • Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

    Charles D. Cox;Chilman Bae;Lynn Ziegler;Silas Hartley

  • Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.

    Thomas M. Suchyna;Janice H. Johnson;Katherine Hamer;Joseph F. Leykam

  • Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.

    Thomas M. Suchyna;Sonya E. Tape;Roger E. Koeppe;Olaf S. Andersen

  • Tarantula peptide inhibits atrial fibrillation.

    Frank Bode;Frederick Sachs;Michael R. Franz

  • Stretch-Activated Ion Channels in the Heart

    Hai Hu;Hai Hu;Frederick Sachs;Frederick Sachs

  • Mechanical transduction in biological systems.

    Sachs F

  • Stretch-Activated Ion Channels: What Are They?

    Frederick Sachs

  • Polycystin-1 and -2 Dosage Regulates Pressure Sensing

    Reza Sharif-Naeini;Joost H.A. Folgering;Delphine Bichet;Fabrice Duprat

  • Mechanosensitive ion channels in nonspecialized cells

    F. Sachs;C. E. Morris

  • Voltage-induced membrane movement.

    Ping-Cheng Zhang;Asbed M. Keleshian;Frederick Sachs

  • Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

    Chilman Bae;Radhakrishnan Gnanasambandam;Chris Nicolai;Frederick Sachs

  • Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse

    Ella W. Yeung;Nicholas P. Whitehead;Thomas M. Suchyna;Philip A. Gottlieb

  • Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation

    M. Sokabe;F. Sachs;Zhonggi Jing

  • Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels.

    W. Sigurdson;A. Ruknudin;F. Sachs

  • Revisiting TRPC1 and TRPC6 mechanosensitivity

    Philip Gottlieb;Joost Folgering;Rosario Maroto;Albert Raso

Frequent Co-Authors

Seth L. Alper
Seth L. Alper Beth Israel Deaconess Medical Center
Boris Martinac
Boris Martinac Victor Chang Cardiac Research Institute
Eric Honoré
Eric Honoré Grenoble Alpes University
Masahiro Sokabe
Masahiro Sokabe Nagoya University
Carlo Brugnara
Carlo Brugnara Boston Children's Hospital
Dorien J.M. Peters
Dorien J.M. Peters Leiden University Medical Center
David G. Nathan
David G. Nathan Harvard University
Leo E. Otterbein
Leo E. Otterbein Beth Israel Deaconess Medical Center
Michel Lazdunski
Michel Lazdunski Centre national de la recherche scientifique, CNRS
Anthony J. Ricci
Anthony J. Ricci Stanford University

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