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Biology and Biochemistry

D-Index
73
Citations
22151
World Ranking
5869
National Ranking
169

Overview

Florian Lesage is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily focuses on the molecular and cellular mechanisms underlying ion channel regulation and function, with particular emphasis on cardiovascular and neuroscience topics.

Lesage's body of work spans fields including Biochemistry, Genetics and Molecular Biology, and Medicine. Subfields of study within their publications include Molecular Biology, Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Physiology, and Sensory Systems.

The scientist has authored papers covering topics such as:

  • Ion channel regulation and function
  • Cardiac electrophysiology and arrhythmias
  • Cardiomyopathy and Myosin Studies
  • Neuroscience and Neuropharmacology Research
  • Ion Channels and Receptors
  • Neuroscience and Neural Engineering
  • Pain Mechanisms and Treatments

Some of the recent publications by Florian Lesage include:

  • "Piezo1 and Piezo2 foster mechanical gating of K2P channels," 2021, Cell Reports
  • "Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome," 2020, Nature Communications
  • "Physiological roles of heteromerization: focus on the two-pore domain potassium channels," 2020, The Journal of Physiology
  • "A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals," 2023, Nature Communications
  • "TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects," 2020, British Journal of Pharmacology

Frequent coauthors collaborating with Lesage include:

  • Sylvain Féliciangéli
  • Franck C. Chatelain
  • Delphine Bichet
  • Michel De Waard
  • Jérôme Montnach

The scientist's work has appeared in multiple journals, with recurrent publications in:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The Journal of Physiology
  • Clinical and Translational Medicine

Best Publications

  • K v LQT1 and IsK (minK) proteins associate to form the I KS cardiac potassium current

    Jacques Barhanin;Florian Lesage;Eric Guillemare;Michel Fink

  • Inhalational anesthetics activate two-pore-domain background K+ channels.

    Amanda J. Patel;Eric Honoré;Florian Lesage;Michel Fink

  • Molecular and functional properties of two-pore-domain potassium channels

    Florian Lesage;Michel Lazdunski

  • TASK, a human background K+ channel to sense external pH variations near physiological pH.

    Fabrice Duprat;Florian Lesage;Michel Fink;Roberto Reyes

  • A mammalian two pore domain mechano‐gated S‐like K+ channel

    Amanda J. Patel;Eric Honoré;François Maingret;Florian Lesage

  • TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.

    F. Lesage;E. Guillemare;M. Fink;F. Duprat

  • International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels

    George A. Gutman;K. George Chandy;John P. Adelman;Jayashree Aiyar

  • Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.

    M Fink;F Duprat;F Lesage;R Reyes

  • TREK-1 is a heat-activated background K(+) channel.

    François Maingret;Inger Lauritzen;Amanda J. Patel;Catherine Heurteaux

  • A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids

    Michel Fink;Florian Lesage;Fabrice Duprat;Catherine Heurteaux

  • Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel.

    François Maingret;Amanda J. Patel;Florian Lesage;Michel Lazdunski

  • Inner Ear Defects Induced by Null Mutation of the isk Gene

    Douglas E Vetter;Jeffrey R Mann;Philine Wangemann;Jianzhong Liu

  • TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel

    François Maingret;Michel Fosset;Florian Lesage;Michel Lazdunski

  • Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK.

    François Maingret;Amanda J. Patel;Florian Lesage;Michel Lazdunski

  • Cloning and expression of a novel pH-sensitive two pore domain K^+ channel from human kidney

    Roberto Reyes;Fabrice Duprat;Florian Lesage;Michel Fink

  • Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.

    Florian Lesage;Cécile Terrenoire;Georges Romey;Michel Lazdunski

  • RIM Binding Proteins (RBPs) Couple Rab3-Interacting Molecules (RIMs) to Voltage-Gated Ca2+ Channels

    H. Hibino;R. Pironkova;O. Onwumere;M. Vologodskaia

  • International Union of Pharmacology. LV. Nomenclature and Molecular Relationships of Two-P Potassium Channels

    Steve A. N. Goldstein;Douglas A. Bayliss;Donghee Kim;Florian Lesage

  • Cloning provides evidence for a family of inward rectifier and G‐protein coupled K+ channels in the brain

    Florian Lesage;Fabrice Duprat;Michel Fink;Eric Guillemare

  • TWIK-1, a ubiquitous humanweaklyinward rectifying K+channel witha novelstructure

    Florian Lesage;Michel Fink;Fabrice Duprat;Michel Lazdunski

Frequent Co-Authors

Michel Lazdunski
Michel Lazdunski Centre national de la recherche scientifique, CNRS
Jacques Barhanin
Jacques Barhanin Centre national de la recherche scientifique, CNRS
Eric Honoré
Eric Honoré Grenoble Alpes University
Georges Romey
Georges Romey Centre national de la recherche scientifique, CNRS
Catherine Heurteaux
Catherine Heurteaux Centre national de la recherche scientifique, CNRS
Michel Fosset
Michel Fosset Centre national de la recherche scientifique, CNRS
Douglas A. Bayliss
Douglas A. Bayliss University of Virginia
Ehud Y. Isacoff
Ehud Y. Isacoff University of California, Berkeley
Enzo Lalli
Enzo Lalli Centre national de la recherche scientifique, CNRS
Rita Raisman-Vozari
Rita Raisman-Vozari Université Paris Cité

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