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Biology and Biochemistry

D-Index
58
Citations
10247
World Ranking
13359
National Ranking
5682

Overview

Debra Crumrine is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on Dermatology, Cell Biology, Immunology and Allergy, Biotechnology, and Pharmaceutical Science.

The main topics covered in their work include Dermatology and Skin Diseases, Skin and Cellular Biology Research, Transgenic Plants and Applications, Advancements in Transdermal Drug Delivery, Exercise and Physiological Responses, Food Allergy and Anaphylaxis Research, and Cell Adhesion Molecules Research.

Debra Crumrine has published research in several key scientific venues. Frequent publication venues include:

  • Journal of Investigative Dermatology
  • Research Square (Research Square)
  • Cell Host & Microbe
  • Cells
  • bioRxiv (Cold Spring Harbor Laboratory)

Notable recent papers authored or co-authored by Crumrine include:

  • "Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor" (2021, Cell Host & Microbe)
  • "Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis" (2020, Cells)
  • "Mitochondrial Activity Is Upregulated in Nonlesional Atopic Dermatitis and Amenable to Therapeutic Intervention" (2022, Journal of Investigative Dermatology)
  • "Commensal Microbiota Regulates Skin Barrier Function And Repair Via Signaling Through The Aryl Hydrocarbon Receptor" (2020, bioRxiv (Cold Spring Harbor Laboratory))
  • "Unique skin abnormality in patients with peanut allergy but no atopic dermatitis" (2020, Journal of Allergy and Clinical Immunology)

In collaboration, Debra Crumrine frequently works with several co-authors including:

  • Peter M. Elias
  • Jason M. Meyer
  • Joan S. Wakefield
  • Kyong-Oh Shin
  • Bogyeong Kim

Their research contributions span various aspects of skin biology, barrier function, and immunological responses relevant to dermatological conditions such as atopic dermatitis and allergy-related skin abnormalities. The work integrates cell biology and molecular pathways alongside therapeutic intervention strategies.

Best Publications

  • Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.

    Jack S. Kao;Joachim W. Fluhr;Joachim W. Fluhr;Mao-Qiang Man;Ashley J. Fowler

  • Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

    Tiffany C. Scharschmidt;Mao Qiang Man;Yutaka Hatano;Debra Crumrine

  • Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.

    Karin M. Aberg;Mao Qiang Man;Richard L. Gallo;Tomas Ganz

  • Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

    Robert Gruber;Peter M. Elias;Debra Crumrine;Tzu Kai Lin

  • Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice.

    Joachim W. Fluhr;Joachim W. Fluhr;Man Mao-Qiang;Barbara E. Brown;Philip W. Wertz

  • Sustained Serine Proteases Activity by Prolonged Increase in pH Leads to Degradation of Lipid Processing Enzymes and Profound Alterations of Barrier Function and Stratum Corneum Integrity

    Jean-Pierre Hachem;Jean-Pierre Hachem;Mao-Quiang Man;Debra Crumrine;Yoshikazu Uchida

  • Modulations in epidermal calcium regulate the expression of differentiation-specific markers.

    Peter M. Elias;Peter M. Elias;Sung K. Ahn;Sung K. Ahn;Mitsuhiro Denda;Barbara E. Brown

  • NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging.

    Martin J. Behne;Jamie W. Meyer;Kerry M. Hanson;Nicholas P. Barry

  • Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity

    Eung Ho Choi;Eung Ho Choi;Barbara E. Brown;Barbara E. Brown;Debra Crumrine;Debra Crumrine;Sandra Chang;Sandra Chang

  • Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome

    Jean Pierre Hachem;Fredrik Wagberg;Matthias Schmuth;Debra Crumrine

  • Stratum Corneum Acidification Is Impaired in Moderately Aged Human and Murine Skin

    Eung Ho Choi;Eung Ho Choi;Mao Qiang Man;Pu Xu;Shujun Xin

  • Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth.

    Zhongjion Xie;László Komuves;Qian-Chun Yu;Hashem Elalieh

  • The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype

    Donald Y. M. Leung;Agustin Calatroni;Livia S. Zaramela;Petra K. LeBeau

  • Hyaluronan–CD44 Interaction Stimulates Keratinocyte Differentiation, Lamellar Body Formation/Secretion, and Permeability Barrier Homeostasis

    Lilly Y W Bourguignon;Mohamed Ramez;Eli Gilad;Patrick A Singleton

  • Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: A proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope

    Yuxiang Zheng;Huiyong Yin;William E. Boeglin;Peter M. Elias

  • Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10

    Keith A. Choate;Yin Lu;Jing Zhou;Murim Choi

  • Formation and functions of the corneocyte lipid envelope (CLE).

    Peter M. Elias;Peter M. Elias;Robert Gruber;Debra Crumrine;Gopinathan Menon

  • Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor

    Aayushi Uberoi;Casey Bartow-McKenney;Qi Zheng;Laurice Flowers

  • Basis for abnormal desquamation and permeability barrier dysfunction in RXLI.

    Peter M. Elias;Debra Crumrine;Ulrich Rassner;Jean-Pierre Hachem

  • 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

    D.D. Bikle;S. Chang;D. Crumrine;H. Elalieh

Frequent Co-Authors

Peter M. Elias
Peter M. Elias University of California, San Francisco
Kenneth R. Feingold
Kenneth R. Feingold University of California, San Francisco
Theodora M. Mauro
Theodora M. Mauro University of California, San Francisco
Yoshikazu Uchida
Yoshikazu Uchida University of California, San Francisco
Matthias Schmuth
Matthias Schmuth Innsbruck Medical University
Barbara E. Brown
Barbara E. Brown University of California, San Francisco
Walter M. Holleran
Walter M. Holleran University of California, San Francisco
Erwin Tschachler
Erwin Tschachler Medical University of Vienna
Gopinathan K. Menon
Gopinathan K. Menon California Academy of Sciences
Amy S. Paller
Amy S. Paller Northwestern University

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