Cahir J. O'Kane

Overview

Best Publications

• Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

  Brinda Ravikumar;Coralie Vacher;Zdenek Berger;Janet E Davies

  2746
  Citations

• Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

  Sean T Sweeney;Kendal Broadie;John Keane;Heiner Niemann

  1124
  Citations

• Detection in situ of genomic regulatory elements in Drosophila.

  Cahir J. O'Kane;Walter J. Gehring

  1034
  Citations

• Lysosomal positioning coordinates cellular nutrient responses

  Viktor I. Korolchuk;Shinji Saiki;Maike Lichtenberg;Farah H. Siddiqi

  963
  Citations

• α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

  Ashley R. Winslow;Chien-Wen Chen;Silvia Corrochano;Abraham Acevedo-Arozena

  921
  Citations

• Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

  Andrea Williams;Sovan Sarkar;Paul Cuddon;Evangelia K Ttofi

  914
  Citations

• P-element-mediated enhancer detection: a versatile method to study development in Drosophila.

  Hugo J. Bellen;Cahir J. O'Kane;Clive Wilson;Ueli Grossniklaus

  863
  Citations

• Rapamycin alleviates toxicity of different aggregate-prone proteins.

  Zdenek Berger;Brinda Ravikumar;Fiona M. Menzies;Lourdes Garcia Oroz

  817
  Citations

• Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

  Sovan Sarkar;Ethan O Perlstein;Ethan O Perlstein;Sara Imarisio;Sandra Pineau

  688
  Citations

• Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies

  John B. Connolly;Ian J. H. Roberts;J. Douglas Armstrong;Kim Kaiser

  585
  Citations

• Dynein mutations impair autophagic clearance of aggregate-prone proteins.

  Brinda Ravikumar;Abraham Acevedo-Arozena;Sara Imarisio;Zdenek Berger

  538
  Citations

• Rapamycin pre-treatment protects against apoptosis

  Brinda Ravikumar;Zdenek Berger;Coralie Vacher;Cahir J. O'Kane

  502
  Citations

• P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila.

  Clive Wilson;Rebecca Kurth Pearson;Hugo J. Bellen;Cahir J. O'Kane

  495
  Citations

• Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila.

  Kendal Broadie;Andreas Prokop;Hugo J. Bellen;Cahir J. O'Kane

  476
  Citations

• The DrosDel Collection: A Set of P-Element Insertions for Generating Custom Chromosomal Aberrations in Drosophila melanogaster

  Edward Ryder;Fiona Blows;Michael Ashburner;Rosa Bautista-Llacer

  413
  Citations

• Complex Inhibitory Effects of Nitric Oxide on Autophagy

  Sovan Sarkar;Viktor I. Korolchuk;Maurizio Renna;Sara Imarisio

  405
  Citations

• A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin

  Sovan Sarkar;Gauri Krishna;Sara Imarisio;Shinji Saiki

  396
  Citations

• Hereditary spastic paraplegias: membrane traffic and the motor pathway

  Craig Blackstone;Cahir J. O'Kane;Evan Reid

  347
  Citations

• Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

  Brinda Ravikumar;Sara Imarisio;Sovan Sarkar;Cahir J. O'Kane

  344
  Citations

• Erratum: Hereditary spastic paraplegias: membrane traffic and the motor pathway

  Craig Blackstone;Cahir J. O'Kane;Evan Reid

  202
  Citations