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C. Richard Hutchinson

C. Richard Hutchinson

D-Index & Metrics

Chemistry

D-Index
71
Citations
14483
World Ranking
5700
National Ranking
141

Research.com Recognitions

  • 1983 - Fellow of John Simon Guggenheim Memorial Foundation

Best Publications

  • Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

    Jonathan Kennedy;Karine Auclair;Steven G. Kendrew;Cheonseok Park

  • Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

    Paul R. August;Li Tang;Yeo J. Yoon;Sandra Ning

  • A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases

    Ralph Reid;Misty Piagentini;Eduardo Rodriguez;Gary Ashley

  • Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase.

    John R. Jacobsen;C. Richard Hutchinson;David E. Cane;Chaitan Khosla

  • Metagenomic Analysis Reveals Diverse Polyketide Synthase Gene Clusters in Microorganisms Associated with the Marine Sponge Discodermia dissoluta

    Andreas Schirmer;Rishali Gadkari;Christopher D. Reeves;Fadia Ibrahim

  • Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)

    J. Vara;M. Lewandowska-Skarbek;Yi-Guang Wang;S. Donadio

  • Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

    Karine Auclair;Andrew Sutherland;Jonathan Kennedy;David J. Witter

  • Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

    M J Bibb;S Biró;H Motamedi;J F Collins

  • Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

    F. Malpartida;F. Malpartida;S. E. Hallam;H. M. Kieser;H. Motamedi

  • POLYKETIDE SYNTHASE GENE MANIPULATION: A Structure-Function Approach in Engineering Novel Antibiotics

    Unknown

  • Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production

    Richard G. Summers;Stefano Donadio;Michael J. Staver;Evelyn Wendt-Pienkowski

  • Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602

    Andreas Rascher;Zhihao Hu;Nina Viswanathan;Andreas Schirmer

  • A multiplasmid approach to preparing large libraries of polyketides

    Qun Xue;Gary Ashley;C. Richard Hutchinson;Daniel V. Santi

  • A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.

    Unknown

  • A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms.

    K T Seow;G Meurer;M Gerlitz;E Wendt-Pienkowski

  • Tetrahedron report number 105

    Unknown

  • Alteration of the Substrate Specificity of a Modular Polyketide Synthase Acyltransferase Domain through Site-Specific Mutations

    Unknown

  • Biosynthetic Studies of Daunorubicin and Tetracenomycin C

    Unknown

  • Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively.

    Tin-Wein Yu;Yuemao Shen;Yukiko Doi-Katayama;Li Tang

  • Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.

    Unknown

Frequent Co-Authors

John C. Vederas
John C. Vederas University of Alberta
Cheon-Seok Park
Cheon-Seok Park Kyung Hee University
Chaitan Khosla
Chaitan Khosla Stanford University
David A. Hopwood
David A. Hopwood John Innes Centre
David E. Cane
David E. Cane Brown University
Heinz G. Floss
Heinz G. Floss University of Washington
Ben Shen
Ben Shen Scripps Research Institute
Carmen Méndez
Carmen Méndez University of Oviedo
Leonard Katz
Leonard Katz Haskins Laboratories
Lutz F. Tietze
Lutz F. Tietze University of Göttingen

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