2023 - Research.com Biology and Biochemistry in Russia Leader Award
2019 - Member of the National Academy of Sciences
His primary scientific interests are in Ribosome, Biochemistry, Translation, Protein biosynthesis and Ribosomal RNA. His Ribosome study incorporates themes from Crystallography, A-site and Biophysics. Alexander S. Spirin has researched Translation in several fields, including Elongation factor and Molecular biology.
His Molecular biology study integrates concerns from other disciplines, such as Cytoplasm, Cell biology, Ribonucleoprotein, Eukaryotic translation and Eukaryotic initiation factor. His Protein biosynthesis research focuses on Protein folding and how it relates to Protein tertiary structure, Heme binding and Globin. His Ribosomal RNA research includes themes of GTP' and Chromosomal translocation.
His primary areas of investigation include Ribosome, Biochemistry, Translation, Ribosomal RNA and Protein biosynthesis. His Ribosome research is multidisciplinary, relying on both Biophysics, Transfer RNA and Escherichia coli. He has included themes like Computational biology and Cell biology in his Translation study.
As part of the same scientific family, Alexander S. Spirin usually focuses on Ribosomal RNA, concentrating on 30S and intersecting with 50S. He interconnects Start codon, Protein folding and Cell-free system in the investigation of issues within Protein biosynthesis. The Messenger RNA study combines topics in areas such as RNA, Ribonucleoprotein, Molecular biology and Polysome.
Alexander S. Spirin mostly deals with Ribosome, Translation, Messenger RNA, Protein biosynthesis and Molecular biology. His Ribosome research entails a greater understanding of Biochemistry. Alexander S. Spirin usually deals with Protein biosynthesis and limits it to topics linked to Translation system and Ribonucleoprotein particle.
His Molecular biology research includes elements of Five prime untranslated region, Eukaryotic translation, Eukaryotic Small Ribosomal Subunit, Computational biology and Initiation factor. The concepts of his Eukaryotic Small Ribosomal Subunit study are interwoven with issues in Eukaryotic Large Ribosomal Subunit and Eukaryotic Ribosome. His study in Polysome is interdisciplinary in nature, drawing from both Untranslated region and Cell biology.
His main research concerns Protein biosynthesis, Molecular biology, Ribosome, Biochemistry and Biophysics. His Protein biosynthesis research is multidisciplinary, incorporating elements of Translation, Messenger RNA and Integral membrane protein. His biological study spans a wide range of topics, including Wheat germ, Computational biology and Start codon.
His Molecular biology study combines topics in areas such as Structural biology, Eukaryotic translation, Five prime untranslated region and Fusion protein. His work on Bacteria expands to the thematically related Biochemistry. Alexander S. Spirin works mostly in the field of Biophysics, limiting it down to topics relating to Ribosomal RNA and, in certain cases, EIF1.
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A continuous cell-free translation system capable of producing polypeptides in high yield.
Alexander S. Spirin;Vladimir I. Baranov;Lubov'a. Ryabova;Sergey Yu. Ovodov.
Factor-free (“Non-enzymic”) and factor-dependent systems of translation of polyuridylic acid by Escherichia coli ribosomes
L.P. Gavrilova;O.E. Kostiashkina;V.E. Koteliansky;N.M. Rutkevitch.
Journal of Molecular Biology (1976)
Use of formaldehyde fixation for studies of ribonucleoprotein particles by caesium chloride density-gradient centrifugation.
A.S. Spirin;N.V. Belitsina;M.I. Lerman.
Journal of Molecular Biology (1965)
High-throughput cell-free systems for synthesis of functionally active proteins
Alexander S. Spirin.
Trends in Biotechnology (2004)
Functional antibody production using cell-free translation: Effects of protein disulfide isomerase and chaperones
Lyubov A. Ryabova;Dominique Desplancq;Dominique Desplancq;Alexander S. Spirin;Andreas Plückthun.
Nature Biotechnology (1997)
Informosomes and their protein components: the present state of knowledge.
A.A. Preobrazhensky;A.S. Spirin.
Progress in Nucleic Acid Research and Molecular Biology (1978)
Studies on the structure of ribosomes
L.P. Gavrilova;D.A. Ivanov;A.S. Spirin.
Journal of Molecular Biology (1966)
Folding of firefly luciferase during translation in a cell-free system.
V.A. Kolb;E.V. Makeyev;A.S. Spirin.
The EMBO Journal (1994)
Cotranslational Folding of Globin
Anton A. Komar;Aigar Kommer;Igor A. Krasheninnikov;Alexander S. Spirin.
Journal of Biological Chemistry (1997)
Stimulation of “non-enzymic” translocation in ribosomes by p-chloromercuribenzoate
L.P. Gavrilova;A.S. Spirin.
FEBS Letters (1971)
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