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Neuroscience

D-Index
55
Citations
10672
World Ranking
4725
National Ranking
2131

Overview

Yun Guan is affiliated with Johns Hopkins University School of Medicine in the United States. Their research primarily focuses on medicine and neuroscience, with specific expertise in physiology, molecular biology, cellular and molecular neuroscience, neurology, and pharmacology.

Their work covers a variety of topics related to pain, including:

  • Pain Mechanisms and Treatments
  • Pain Management and Treatment
  • Musculoskeletal pain and rehabilitation
  • Neuropeptides and Animal Physiology
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Spine and Intervertebral Disc Pathology
  • Anesthesia and Pain Management

They have published several research papers in notable journals and scientific venues. Some recent examples include:

  • Utility of ctDNA in predicting response to neoadjuvant chemoradiotherapy and prognosis assessment in locally advanced rectal cancer: A prospective cohort study (2021, PLoS Medicine)
  • ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain (2023, Science Advances)
  • Astrocytes contribute to pain gating in the spinal cord (2021, Science Advances)
  • Role of Vagus Nerve Stimulation in the Treatment of Chronic Pain (2023, NeuroImmunoModulation)
  • PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib (2021, Bone Research)

Yun Guan frequently collaborates with several researchers, including:

  • Xinzhong Dong
  • Neil C. Ford
  • Qian Huang
  • Shao-Qiu He
  • Xu Cao

Their publications often appear in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Pain
  • Research Square (Research Square)
  • eLife
  • Neuromodulation Technology at the Neural Interface

Best Publications

  • Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

    Qin Liu;Zongxiang Tang;Lenka Surdenikova;Seungil Kim

  • A subpopulation of nociceptors specifically linked to itch

    Liang Han;Chao Ma;Qin Liu;Hao Jui Weng

  • Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors

    Rebecca P. Seal;Xingmei Wang;Yabo Guan;Srinivasa N. Raja

  • Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

    Shouan Zhu;Jianxi Zhu;Jianxi Zhu;Gehua Zhen;Yihe Hu

  • Spinal Cord Stimulation: Clinical Efficacy and Potential Mechanisms.

    Andrei D. Sdrulla;Yun Guan;Srinivasa N. Raja

  • Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

    Wei Xiong;Tanxing Cui;Kejun Cheng;Fei Yang

  • Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

    Yu Shin Kim;Yu Shin Kim;Michael Anderson;Kyoungsook Park;Qin Zheng

  • Tyrosine Phosphorylation of the NR2B Subunit of the NMDA Receptor in the Spinal Cord during the Development and Maintenance of Inflammatory Hyperalgesia

    Wei Guo;Shiping Zou;Yun Guan;Tetsuya Ikeda

  • Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

    Hao Chen;Hao Chen;Bo Hu;Bo Hu;Xiao Lv;Shouan Zhu

  • TRP Vanilloid 2 Knock-Out Mice Are Susceptible to Perinatal Lethality But Display Normal Thermal and Mechanical Nociception

    Una Park;Nisha Vastani;Yun Guan;Srinivasa N. Raja

  • Parameters of Spinal Cord Stimulation and Their Role in Electrical Charge Delivery: A Review

    Jonathan P. Miller;Sam Eldabe;Eric Buchser;Lisa M. Johanek

  • Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats

    Yun Guan;Paul W. Wacnik;Fei Yang;Alene F. Carteret

  • Conventional and Kilohertz-frequency Spinal Cord Stimulation Produces Intensity- and Frequency-dependent Inhibition of Mechanical Hypersensitivity in a Rat Model of Neuropathic Pain

    Ronen Shechter;Fei Yang;Qian Xu;Yong Kwan Cheong

  • Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain

    Hao Jui Weng;Hao Jui Weng;Kush N. Patel;Nathaniel A. Jeske;Sonya M. Bierbower

  • Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation.

    Kenji Miki;Q. Q. Zhou;W. Guo;Y. Guan

  • Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord

    Shuohao Sun;Qian Xu;Changxiong Guo;Yun Guan

  • Spinal Cord Stimulation: Neurophysiological and Neurochemical Mechanisms of Action

    Yun Guan

  • Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice.

    Yun Guan;Myron Yaster;Srinivasa N. Raja;Yuan Xiang Tao

  • Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain.

    Ya Chun Chu;Yun Guan;John Skinner;Srinivasa N. Raja

  • Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury.

    Yun Guan;Lisa M. Johanek;Timothy V. Hartke;Beom Shim

  • Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice.

    Shuangfei Ni;Zemin Ling;Zemin Ling;Xiao Wang;Yong Cao;Yong Cao

Frequent Co-Authors

Xinzhong Dong
Xinzhong Dong Johns Hopkins University School of Medicine
Richard A. Meyer
Richard A. Meyer Johns Hopkins University
Yuan Xiang Tao
Yuan Xiang Tao Rutgers, The State University of New Jersey
Ke Ren
Ke Ren University of Maryland, Baltimore
Bengt Linderoth
Bengt Linderoth Karolinska Institute
Matthias Ringkamp
Matthias Ringkamp Johns Hopkins University
Jeffrey D. Rothstein
Jeffrey D. Rothstein Johns Hopkins University
Norman J. Haughey
Norman J. Haughey Tulane University
Ahmet Hoke
Ahmet Hoke Johns Hopkins University
Feng Wei
Feng Wei University of Maryland, Baltimore

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