World's Best Scientists 2026 revealed!

Overview

Weiliang Xia is affiliated with Shanghai Jiao Tong University in China and has a significant body of work in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research emphases include Molecular Biology, Oncology, Cancer Research, Epidemiology, and Hepatology.

The scientist's research covers a broad range of topics, prominently featuring extracellular vesicles in disease, microRNA in disease regulation, cancer immunotherapy and biomarkers, sirtuins and resveratrol in medicine, circular RNAs in diseases, fibroblast growth factor research, and cancer-related molecular mechanisms research.

Frequent coauthors collaborating with Weiliang Xia include Yirui Cheng, Qing Han, Tingyu Wu, Yanshuang Zhang, and Shun Lü.

Some of the common publication venues for their work are Oncogene, Theranostics, Research Square, Cellular Oncology, and the Journal of Agricultural and Food Chemistry.

Selected recent papers authored by or involving Weiliang Xia are:

  • Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer, 2021, Theranostics
  • Celery (Apium graveolens L.) Exosome-like Nanovesicles as a New-Generation Chemotherapy Drug Delivery Platform against Tumor Proliferation, 2023, Journal of Agricultural and Food Chemistry
  • Transcriptional regulation of PRKAR2B by miR-200b-3p/200c-3p and XBP1 in human prostate cancer, 2020, Biomedicine & Pharmacotherapy
  • Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1α/VEGF Signaling and Blood-Brain Barrier Integrity, 2020, Cellular and Molecular Neurobiology
  • Comparison of serum exosome isolation methods on co-precipitated free microRNAs, 2020, PeerJ

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells.

    Lilly Y.W. Bourguignon;Karine Peyrollier;Karine Peyrollier;Weiliang Xia;Weiliang Xia;Eli Gilad;Eli Gilad

  • Hyaluronan-CD44 Interaction with Protein Kinase Cϵ Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells

    Lilly Y.W. Bourguignon;Christina C. Spevak;Gabriel Wong;Weiliang Xia

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • A mesoporous silica nanoparticle--PEI--fusogenic peptide system for siRNA delivery in cancer therapy.

    Xu Li;Yijie Chen;Mingqi Wang;Yongjie Ma

  • Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes.

    Yirui Cheng;Qingyu Zeng;Qing Han;Weiliang Xia

  • Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes.

    Michelle W M Li;Weiliang Xia;Dolores D Mruk;Claire Q F Wang

  • CD44 variant isoforms in head and neck squamous cell carcinoma progression.

    Steven J. Wang;Gabriel Wong;Anne-Martine de Heer;Weiliang Xia

  • Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells

    Lilly Y.W. Bourguignon;Weiliang Xia;Gabriel Wong

  • TGF-β3 and TNFα perturb blood-testis barrier (BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: A new concept of BTB regulation during spermatogenesis

    Weiliang Xia;Elissa W.P. Wong;Dolores D. Mruk;C. Yan Cheng

  • The packaging of siRNA within the mesoporous structure of silica nanoparticles

    Xu Li;Qian Reuben Xie;Jixi Zhang;Weiliang Xia

  • FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer.

    Kaixuan Wang;Wenxiang Ji;Yongfeng Yu;Ziming Li

  • Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NFκB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion.

    Lilly Y. W. Bourguignon;Gabriel Wong;Christine A. Earle;Weiliang Xia

  • Differential Interactions between Transforming Growth Factor-β3/TβR1, TAB1, and CD2AP Disrupt Blood-Testis Barrier and Sertoli-Germ Cell Adhesion

    Weiliang Xia;Dolores D. Mruk;Will M. Lee;C. Yan Cheng

  • Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells

    Qian Liu;Jixi Zhang;Wei Sun;Qian Reuben Xie

  • Regulation of Sertoli-Germ Cell Adherens Junction Dynamics via Changes in Protein-Protein Interactions of the N-Cadherin-β-Catenin Protein Complex which Are Possibly Mediated by c-Src and Myotubularin-Related Protein 2: An in Vivo Study Using an Androgen Suppression Model

    Jiayi Zhang;Ching-hang Wong;Weiliang Xia;Dolores D. Mruk

  • Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics

    Yewei Liu;Qian Reuben Xie;Boshi Wang;Jiaxiang Shao

  • TGF-β3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway : An in vivo study

    Weiliang Xia;C. Yan Cheng

  • Regulation of Ectoplasmic Specialization Dynamics in the Seminiferous Epithelium by Focal Adhesion-Associated Proteins in Testosterone-Suppressed Rat Testes

    Ching-Hang Wong;Weiliang Xia;Nikki P. Y. Lee;Dolores D. Mruk

  • Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier.

    Yijie Chen;Hongchen Gu;Ding Sheng-Zi Zhang;Fan Li

Frequent Co-Authors

Dolores D. Mruk
Dolores D. Mruk Population Council
C. Yan Cheng
C. Yan Cheng Population Council
Hongchen Gu
Hongchen Gu Shanghai Jiao Tong University
Will M. Lee
Will M. Lee University of Hong Kong
Wei-Qiang Gao
Wei-Qiang Gao Shanghai Jiao Tong University
Qian Liu
Qian Liu Chengdu University
Lilly Y. W. Bourguignon
Lilly Y. W. Bourguignon University of California, San Francisco
Xiao Yang
Xiao Yang Shanghai Jiao Tong University
Dabing Zhang
Dabing Zhang Shanghai Jiao Tong University
Haiyan Li
Haiyan Li Shanghai Jiao Tong University

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