World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
13913
World Ranking
13063
National Ranking
5569

Overview

Timothy D. Howard is affiliated with Wake Forest University in the United States. Their research spans several fields within medicine and biochemistry, genetics, and molecular biology, with a particular focus on systemic lupus erythematosus, musculoskeletal pain and rehabilitation, and eosinophilic esophagitis.

The scientist's published work includes investigations into chronic pain prediction, genetic control points in lipid biology, and the identification of unique biological networks and drug targets in diverse ancestries. Notable recent papers include:

  • Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures (2023, Pain)
  • FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids (2020, Scientific Reports)
  • Analysis of Trans-Ancestral SLE Risk Loci Identifies Unique Biologic Networks and Drug Targets in African and European Ancestries (2020, The American Journal of Human Genetics)
  • Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry (2021, The American Journal of Human Genetics)
  • Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation, and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans (2020, Diabetes)

Their frequent co-authors reflect collaborations with several researchers, including:

  • Carl D. Langefeld
  • Gregory A. Hawkins
  • Michael Olivier
  • Hannah C. Ainsworth
  • Miranda C. Marion

Publications frequently appear in venues such as UNC Libraries, Gastroenterology, Scientific Reports, Diabetes, and The American Journal of Human Genetics, indicating a strong presence in both clinical and molecular biology research communities.

The scientist's work covers a range of subfields including:

  • Molecular Biology
  • Immunology
  • Genetics
  • Surgery
  • Rheumatology

Research topics addressed across their publications encompass:

  • Systemic Lupus Erythematosus Research
  • Musculoskeletal pain and rehabilitation
  • Eosinophilic Esophagitis
  • Epigenetics and DNA Methylation
  • T-cell and B-cell Immunology
  • Diet and metabolism studies
  • Cancer-related molecular mechanisms research

This profile reflects a research career engaged with diverse aspects of medical and biological sciences, contributing to a variety of topics relevant to disease mechanisms, genetics, and molecular biology.

Best Publications

  • Mutations in TWIST , a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome

    Timothy D. Howard;William A. Paznekas;Eric D. Green;Lydia C. Chiang

  • Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma

    Timothy D. Howard;Gerard H. Koppelman;Jianfeng Xu;Siqun L. Zheng

  • Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease.

    David M Herrington;Timothy D Howard;Gregory A Hawkins;David M Reboussin

  • Transancestral mapping and genetic load in systemic lupus erythematosus

    Carl D. Langefeld;Hannah C. Ainsworth;Deborah S. Cunninghame Graham;Jennifer A. Kelly

  • Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions

    Xingnan Li;Timothy D. Howard;Siqun L. Zheng;Tmirah Haselkorn

  • Common Estrogen Receptor Polymorphism Augments Effects of Hormone Replacement Therapy on E-Selectin but Not C-Reactive Protein

    David M. Herrington;Timothy D. Howard;K. Bridget Brosnihan;Donald P. McDonnell

  • The Need for Multi-Omics Biomarker Signatures in Precision Medicine.

    Michael Olivier;Reto Asmis;Gregory A. Hawkins;Timothy D. Howard

  • Variation in the Interleukin 4–Receptor α Gene Confers Susceptibility to Asthma and Atopy in Ethnically Diverse Populations

    Carole Ober;Stephanie A. Leavitt;Anya Tsalenko;Timothy D. Howard

  • Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population.

    Timothy D. Howard;Paul A. Whittaker;Ari L. Zaiman;Gerard H. Koppelman

  • Genomewide Screen and Identification of Gene-Gene Interactions for Asthma-Susceptibility Loci in Three U.S. Populations: Collaborative Study on the Genetics of Asthma

    Jianfeng Xu;Deborah A. Meyers;Carole Ober;Malcolm N. Blumenthal

  • Association of a promoter polymorphism of the CD14 gene and atopy.

    Gerard H. Koppelman;Naomi E. Reijmerink;O. Colin Stine;Timothy D. Howard

  • Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

    Christopher J. Odonnell;Christopher J. Odonnell;Maryam Kavousi;Albert V. Smith;Sharon L.R. Kardia;Sharon L.R. Kardia

  • A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

    Keri L. Monda;Keri L. Monda;Gary K. Chen;Kira C. Taylor;Kira C. Taylor;Cameron Palmer;Cameron Palmer

  • Fine Mapping and Positional Candidate Studies Identify HLA-G as an Asthma Susceptibility Gene on Chromosome 6p21

    Dan Nicolae;Nancy J. Cox;Lucille A. Lester;Daniel Schneider

  • Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations

    Timothy D Howard;Dirkje S Postma;Hajo Jongepier;Wendy C Moore

  • Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage

    Daniel Woo;Guido J. Falcone;Guido J. Falcone;William J. Devan;William J. Devan;W. Mark Brown

  • Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma

    H Jongepier;Hendrika Boezen;A Dijkstra;T D Howard

  • Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic Nephropathy

    Donald W Bowden;Michèle Sale;Timothy D Howard;Asif Qadri

  • Genetic Heterogeneity of Saethre-Chotzen Syndrome, Due to TWIST and FGFR Mutations

    William A. Paznekas;Michael L. Cunningham;Timothy D. Howard;Bruce R. Korf

  • Genome-wide search for atopy susceptibility genes in Dutch families with asthma

    Gerard H. Koppelman;O.Colin Stine;Jianfeng Xu;Timothy D. Howard

Frequent Co-Authors

Eugene R. Bleecker
Eugene R. Bleecker University of Arizona
Deborah A. Meyers
Deborah A. Meyers University of Arizona
David M. Herrington
David M. Herrington Wake Forest University
Carl D. Langefeld
Carl D. Langefeld Wake Forest University
Gregory A. Hawkins
Gregory A. Hawkins Wake Forest University
Gerard H. Koppelman
Gerard H. Koppelman University Medical Center Groningen
Dirkje S. Postma
Dirkje S. Postma University Medical Center Groningen
Jianfeng Xu
Jianfeng Xu Arkansas State University
Yongmei Liu
Yongmei Liu Duke University
Donald W. Bowden
Donald W. Bowden Wake Forest University

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