World's Best Scientists 2026 revealed!

Overview

Stanley Hoffman is affiliated with the Medical University of South Carolina in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions also in the field of medicine. Key subfields of study include cell biology, molecular biology, cardiology and cardiovascular medicine, pulmonary and respiratory medicine, and immunology and allergy.

The main topics of Hoffman's research encompass Caveolin-1 and its role in various cellular processes, cell adhesion molecules, metabolism related to diabetes and cancer, ion transport and channel regulation, as well as cardiac fibrosis and remodeling and cardiovascular function and risk factors.

Hoffman has published notable papers across several respected journals. Recent publications include:

  • The Caveolin-1 Scaffolding Domain Peptide Reverses Aging-Associated Deleterious Changes in Multiple Organs (2021, Journal of Pharmacology and Experimental Therapeutics)
  • Multiple subregions within the caveolin-1 scaffolding domain inhibit fibrosis, microvascular leakage, and monocyte migration (2022, PLoS ONE)
  • Phenotypic characterization of primary cardiac fibroblasts from patients with HFpEF (2022, PLoS ONE)
  • MicroRNA-510 mediated negative regulation of Caveolin-1 in fibroblasts promotes aggressive tumor growth (2023, Frontiers in Immunology)
  • A water-soluble caveolin-1 peptide inhibits psoriasis-like skin inflammation by suppressing cytokine production and angiogenesis (2024, Scientific Reports)

Frequent coauthors in Hoffman's work include Charles Reese, Dhandapani Kuppuswamy, Chinnakkannu Panneerselvam, Elena Tourkina, and Yuhua Zhang. Publications are concentrated in journals such as PLoS ONE, Frontiers in Immunology, Journal of Pharmacology and Experimental Therapeutics, Scientific Reports, and Matrix Biology.

Best Publications

  • Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule

    Stanley Hoffman;Gerald M. Edelman

  • Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues

    Russell A. Norris;Brook Damon;Vladimir Mironov;Vladimir Kasyanov

  • Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes.

    S Hoffman;B C Sorkin;P C White;R Brackenbury

  • Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β

    Polakit Teekakirikul;Seda Eminaga;Okan Toka;Ronny Alcalai

  • Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction

    Martin Grumet;Stanley Hoffman;Kathryn L. Crossin;Gerald M. Edelman

  • Site-restricted expression of cytotactin during development of the chicken embryo.

    K. L. Crossin;S. Hoffman;Martin Grumet;J. P. Thiery

  • Molecular forms, binding functions, and developmental expression patterns of cytotactin and cytotactin-binding proteoglycan, an interactive pair of extracellular matrix molecules

    S Hoffman;KL Crossin;GM Edelman

  • Binding properties of a cell adhesion molecule from neural tissue.

    Urs Rutishauser;Stanley Hoffman;Gerald M. Edelman

  • Molecular topography of the neural cell adhesion molecule N-CAM: surface orientation and location of sialic acid-rich and binding regions

    Bruce A. Cunningham;Stanley Hoffman;Urs Rutishauser;John J. Hemperly

  • A proteoglycan with HNK-1 antigenic determinants is a neuron-associated ligand for cytotactin

    Stanley Hoffman;Gerald M. Edelman

  • Cytotactin and its proteoglycan ligand mark structural and functional boundaries in somatosensory cortex of the early postnatal mouse.

    Kathryn L. Crossin;Stanley Hoffman;Seong-Seng Tan;Gerald M. Edelman

  • Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase

    Jonathan T. Butcher;Russell A. Norris;Stanley Hoffman;Corey H. Mjaatvedt

  • Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo

    Elena Tourkina;Mathieu Richard;Pal Gööz;Michael Bonner

  • Periostin is expressed within the developing teeth at the sites of epithelial–mesenchymal interaction

    Agnieszka Kruzynska-Frejtag;Jian Wang;Manabu Maeda;Rhonda Rogers

  • Periostin regulates atrioventricular valve maturation

    Russell A. Norris;Ricardo A. Moreno-Rodriguez;Yukiko Sugi;Stanley Hoffman

  • Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions

    S. Hoffman;D. R. Friedlander;Cheng-Ming Chuong;M. Grumet

  • Two antigenically related neuronal cell adhesion molecules of different specificities mediate neuron-neuron and neuron-glia adhesion.

    Martin Grumet;Stanley Hoffman;Gerald M. Edelman

  • Coordinate regulation of cadherin and integrin function by the chondroitin sulfate proteoglycan neurocan.

    Hedong Li;Tin Chung Leung;Tin Chung Leung;Stanley Hoffman;Janne Balsamo;Janne Balsamo

  • Opposing Effects of Protein Kinase Cα and Protein Kinase Cϵ on Collagen Expression by Human Lung Fibroblasts Are Mediated via MEK/ERK and Caveolin-1 Signaling *

    Elena Tourkina;Pal Gooz;Jaspreet Pannu;Michael Bonner

  • Polypeptide components and binding functions of neuron-glia cell adhesion molecules.

    Martin Grumet;Stanley Hoffman;Cheng-Ming Chuong;Gerald M. Edelman

Frequent Co-Authors

Roger R. Markwald
Roger R. Markwald Medical University of South Carolina
Simon J. Conway
Simon J. Conway Indiana University
John L. Bixby
John L. Bixby University of Miami
Carol Feghali-Bostwick
Carol Feghali-Bostwick Medical University of South Carolina
Maria Trojanowska
Maria Trojanowska Boston University
Vincent C. Hascall
Vincent C. Hascall Cleveland Clinic
Vance Lemmon
Vance Lemmon University of Miami
William C. Sessa
William C. Sessa Pfizer (United States)
Jeffrey L. Goldberg
Jeffrey L. Goldberg Stanford University
Bryan P. Toole
Bryan P. Toole Medical University of South Carolina

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