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Medicine

D-Index
87
Citations
30086
World Ranking
13574
National Ranking
6902

Overview

Simon A. Gayther is affiliated with Cedars-Sinai Medical Center in the United States. Their research largely focuses on the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with primary subfields covering Molecular Biology, Genetics, Reproductive Medicine, Cancer Research, and Pathology and Forensic Medicine.

The scientist's work encompasses several main topics, including:

  • Ovarian cancer diagnosis and treatment
  • BRCA gene mutations in cancer
  • Genetic Associations and Epidemiology
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • Cancer Genomics and Diagnostics
  • Endometrial and Cervical Cancer Treatments

Simon A. Gayther has contributed to numerous publications, with several recent papers highlighting diverse cancer genetics research:

  • Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses (2020, Nature Genetics)
  • Prostate cancer reactivates developmental epigenomic programs during metastatic progression (2020, Nature Genetics)
  • Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D (2020, JNCI Journal of the National Cancer Institute)
  • Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers (2020, Nature Communications)
  • Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube (2021, Cell Reports)

The scientist has collaborated frequently with several co-authors, including:

  • Paul D.P. Pharoah
  • Kate Lawrenson
  • Susan J. Ramus
  • Ellen L. Goode
  • Beth Y. Karlan

Their work appears regularly in publications such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Cancer Research
  • Nature Communications
  • Clinical Cancer Research

Best Publications

  • Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

    D Ford;D F Easton;M Stratton;S Narod

  • Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies.

    Celeste Leigh Pearce;Claire Templeman;Mary Anne Rossing;Alice Lee

  • Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

    Andrew E. Teschendorff;Usha Menon;Aleksandra Gentry-Maharaj;Susan J. Ramus

  • Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

    Ganna Chornokur;Hui-Yi Lin;Jonathan P. Tyrer;Kate Lawrenson

  • Mutations truncating the EP300 acetylase in human cancers.

    Simon A. Gayther;Sarah J. Batley;Lori Linger;Andy Bannister

  • Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

    Nasim Mavaddat;Daniel Barrowdale;Irene L. Andrulis;Susan M. Domchek

  • Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer

    Kelly L. Bolton;Kelly L. Bolton;Georgia Chenevix-Trench;Cindy Goh;Siegal Sadetzki

  • Familial gastric cancer: overview and guidelines for management*

    Carlos Caldas;Fatima Carneiro;Henry T Lynch;Jun Yokota

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation.

    S. A. Gayther;W. Warren;S. Mazoyer;P. A. Russell

  • A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene: Implications for Presymptomatic Testing and Screening

    Donna Shattuck Eidens;Melody Mcclure;Jacques Simard;Fernand Labrie

  • Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene

    Simon A. Gayther;Jonathon Mangion;Paul Russell;Sheila Seal

  • Principles for the post-GWAS functional characterization of cancer risk loci

    Matthew L Freedman;Alvaro N A Monteiro;Simon A Gayther;Simon A Gayther;Gerhard A Coetzee

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

    Weiva Sieh;Martin Köbel;Teri A Longacre;David D Bowtell;David D Bowtell

  • Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer

    Susan J. Ramus;Honglin Song;Ed Dicks;Jonathan P. Tyrer

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • Identification of Germ-Line E-cadherin Mutations in Gastric Cancer Families of European Origin

    Simon A. Gayther;Kylie L. Gorringe;Susan J. Ramus;David Huntsman

  • Two Percent of Men with Early-Onset Prostate Cancer Harbor Germline Mutations in the BRCA2 Gene

    Stephen M. Edwards;Zsofia Kote-Jarai;Julia Meitz;Rifat Hamoudi

  • GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

    Paul D.P. Pharoah;Ya Yu Tsai;Susan J. Ramus;Catherine M. Phelan

Frequent Co-Authors

Susan J. Ramus
Susan J. Ramus University of New South Wales
Paul D.P. Pharoah
Paul D.P. Pharoah University of Cambridge
Ellen L. Goode
Ellen L. Goode Mayo Clinic
Joellen M. Schildkraut
Joellen M. Schildkraut University of Virginia
Jenny Chang-Claude
Jenny Chang-Claude German Cancer Research Center
Andrew Berchuck
Andrew Berchuck Duke University
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Beth Y. Karlan
Beth Y. Karlan University of California, Los Angeles
Peter A. Fasching
Peter A. Fasching University of Erlangen-Nuremberg
Usha Menon
Usha Menon University College London

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