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Chemistry

D-Index
43
Citations
9009
World Ranking
17083
National Ranking
4204

Overview

Shane W. Krska is affiliated with MSD (United States) and has a research focus primarily within the field of Chemistry, where they have produced 56 publications. Their work spans several subfields, including Organic Chemistry (51 publications), Biomedical Engineering (10), Molecular Biology (9), Inorganic Chemistry (5), and Radiology, Nuclear Medicine and Imaging (4).

The scientist's research mainly explores topics such as Catalytic C-H Functionalization Methods with 28 publications, Radical Photochemical Reactions and Catalytic Cross-Coupling Reactions each with 18 publications, and Innovative Microfluidic and Catalytic Techniques Innovation with 16 publications. Additional areas of study include Chemical Synthesis and Analysis (10), Cyclopropane Reaction Mechanisms (8), and Oxidative Organic Chemistry Reactions (8).

Over the years, Shane W. Krska has contributed to research published in various venues, with frequent publications in the Journal of the American Chemical Society (5 papers), ACS Catalysis (3), Synlett (3), Science (2), and Accounts of Chemical Research (2).

  • C(sp 3
  • H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling, 2021, Science
  • Copper-catalysed benzylic C-H coupling with alcohols via radical relay enabled by redox buffering, 2020, Nature Catalysis
  • Accelerating reaction generality and mechanistic insight through additive mapping, 2022, Science
  • Chemistry Informer Libraries: Conception, Early Experience, and Role in the Future of Cheminformatics, 2021, Accounts of Chemical Research
  • Copper-Catalyzed Cross-Coupling of Benzylic C-H Bonds and Azoles with Controlled N-Site Selectivity, 2021, Journal of the American Chemical Society

Shane W. Krska collaborates frequently with several scientists. Prominent coauthors include Shannon S. Stahl with eight joint publications, Spencer D. Dreher with six, Timothy Nowak and Petr Váchal each with five, and Si-Jie Chen with four shared papers.

Best Publications

  • The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

    Tim Cernak;Kevin D. Dykstra;Sriram Tyagarajan;Petr Vachal

  • Late‐Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

    Daniel A. DiRocco;Kevin Dykstra;Shane Krska;Petr Vachal

  • Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts

    Max R. Friedfeld;Michael Shevlin;Jordan M. Hoyt;Shane W. Krska

  • The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis.

    Shane W. Krska;Daniel A. DiRocco;Spencer D. Dreher;Michael Shevlin

  • Highly Efficient Asymmetric Synthesis of Sitagliptin

    Karl B. Hansen;Yi Hsiao;Feng Xu;Nelo Rivera

  • Highly Efficient Synthesis of β-Amino Acid Derivatives via Asymmetric Hydrogenation of Unprotected Enamines

    Yi Hsiao;Nelo R. Rivera;Thorsten Rosner;Shane W. Krska

  • A traceless directing group for C-H borylation.

    Sean M. Preshlock;Donald L. Plattner;Peter E. Maligres;Shane W. Krska

  • Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

    Peter S. Kutchukian;James F. Dropinski;Kevin D. Dykstra;Bing Li

  • High-throughput optimization of Ir-catalyzed C-H borylation: a tutorial for practical applications.

    Sean M. Preshlock;Behnaz Ghaffari;Peter E. Maligres;Shane W. Krska

  • Unlocking the Potential of Asymmetric Hydrogenation at Merck

    C. Scott Shultz;Shane W. Krska

  • C(sp 3 )-H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling.

    Aristidis Vasilopoulos;Shane W. Krska;Shannon S. Stahl

  • Accelerating reaction generality and mechanistic insight through additive mapping

    Unknown

  • Copper-catalysed benzylic C-H coupling with alcohols via radical relay enabled by redox buffering.

    Huayou Hu;Si Jie Chen;Mukunda Mandal;Saied Md Pratik

  • Pharmaceutical diversification via palladium oxidative addition complexes

    Mycah R. Uehling;Mycah R. Uehling;Ryan P. King;Shane W. Krska;Tim Cernak;Tim Cernak

  • Silyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis

    Behnaz Ghaffari;Sean M. Preshlock;Donald L. Plattner;Richard J. Staples

  • Zirconium-Mediated Metathesis of Imines: A Study of the Scope, Longevity, and Mechanism of a Complicated Catalytic System

    Rebecca L. Zuckerman;Shane W. Krska;Robert G. Bergman

  • Synthesis of Water-Soluble Carbosilane Dendrimers

    Shane W. Krska;Dietmar Seyferth

  • Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases

    Chelsea A. Huff;Ryan D. Cohen;Kevin D. Dykstra;Eric Streckfuss

  • Protecting group free radical C–H trifluoromethylation of peptides

    Naoko Ichiishi;John P. Caldwell;Melissa Lin;Wendy Zhong

  • Reaction development and mechanistic study of a ruthenium catalyzed intramolecular asymmetric reductive amination en route to the dual Orexin inhibitor Suvorexant (MK-4305).

    Neil A. Strotman;Carl A. Baxter;Karel M. J. Brands;Ed Cleator

  • Designed Ligands as Probes for the Catalytic Binding Mode in Mo-Catalyzed Asymmetric Allylic Alkylation

    Barry M. Trost;Kalindi Dogra;Iwao Hachiya;Takashi Emura

  • Reversed-Polarity Synthesis of Diaryl Ketones via Palladium-Catalyzed Cross-Coupling of Acylsilanes

    Jason R. Schmink;Shane W. Krska

  • Cu-Mediated C–H 18F-Fluorination of Electron-Rich (Hetero)arenes

    Matthew S. McCammant;Stephen Thompson;Allen F. Brooks;Shane W. Krska

Frequent Co-Authors

Robert A. Reamer
Robert A. Reamer MSD (United States)
Edward J. J. Grabowski
Edward J. J. Grabowski MSD (United States)
Milton R. Smith
Milton R. Smith Michigan State University
Robert G. Bergman
Robert G. Bergman University of California, Berkeley
Ian W. Davies
Ian W. Davies Princeton University
Barry M. Trost
Barry M. Trost Stanford University
Shannon S. Stahl
Shannon S. Stahl University of Wisconsin–Madison
Matthew B. Francis
Matthew B. Francis University of California, Berkeley

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