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D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
54684
World Ranking
14721
National Ranking
6148

Overview

Sachet A. Shukla is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research contributions span several key areas within medicine and molecular biology, with a focus on oncology and pulmonary and respiratory medicine.

Their recent publications include studies on cancer immunotherapy, immune responses, and renal cell carcinoma treatment. Notable papers authored or co-authored by Shukla include:

  • Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma, 2020, Nature Medicine
  • Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma, 2021, Nature
  • Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma, 2021, Nature Medicine
  • Progressive immune dysfunction with advancing disease stage in renal cell carcinoma, 2021, Cancer Cell
  • Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche, 2022, Cell

Shukla's frequent co-authors highlight a collaborative research environment and include:

  • Toni K. Choueiri
  • David A. Braun
  • Catherine J. Wu
  • Sabina Signoretti
  • Eliezer M. Van Allen

The principal venues where Shukla publishes research findings include:

  • Journal of Clinical Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Clinical Cancer Research
  • Blood

Shukla's main fields of study cover:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these main disciplines, their work often addresses subfields such as:

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Cancer Research
  • Immunology

Key research topics and areas of investigation include:

  • Cancer Immunotherapy and Biomarkers
  • Renal cell carcinoma treatment
  • Cancer Genomics and Diagnostics
  • Ferroptosis and cancer prognosis
  • Immunotherapy and Immune Responses
  • Single-cell and spatial transcriptomics
  • Immune Cell Function and Interaction

Best Publications

  • Comprehensive molecular characterization of human colon and rectal cancer

    Donna M. Muzny;Matthew N. Bainbridge;Kyle Chang;Huyen H. Dinh

  • The Somatic Genomic Landscape of Glioblastoma

    Cameron W. Brennan;Roel G W Verhaak;Aaron McKenna;Benito Campos

  • Molecular and genetic properties of tumors associated with local immune cytolytic activity.

    Michael S. Rooney;Sachet A. Shukla;Catherine J. Wu;Gad Getz

  • Comprehensive genomic characterization of squamous cell lung cancers

    Peter S. Hammerman;Doug Voet;Michael S. Lawrence;Douglas Voet

  • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

    Nicholas McGranahan;Nicholas McGranahan;Andrew J. S. Furness;Rachel Rosenthal;Sofie Ramskov

  • Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

    Eliezer M. Van Allen;Eliezer M. Van Allen;Diana Miao;Diana Miao;Bastian Schilling;Sachet A. Shukla;Sachet A. Shukla

  • An immunogenic personal neoantigen vaccine for patients with melanoma

    Patrick A. Ott;Zhuting Hu;Derin B. Keskin;Derin B. Keskin;Sachet A. Shukla;Sachet A. Shukla

  • Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

    A. Gordon Robertson;Jaegil Kim;Hikmat Al-Ahmadie;Joaquim Bellmunt

  • Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

    Dan A. Landau;Scott L. Carter;Petar Stojanov;Petar Stojanov;Aaron McKenna

  • Telomere dysfunction induces metabolic and mitochondrial compromise

    Ergiin Sahin;Simona Colla;Marc Liesa;Javid Moslehi

  • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

    Derin B. Keskin;Annabelle J. Anandappa;Jing Sun;Itay Tirosh

  • Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

    Joshua D Campbell;Anton Alexandrov;Jaegil Kim;Jeremiah Wala

  • Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

    Marios Giannakis;Marios Giannakis;Marios Giannakis;Xinmeng Jasmine Mu;Xinmeng Jasmine Mu;Xinmeng Jasmine Mu;Sachet A. Shukla;Sachet A. Shukla;Zhi Rong Qian

  • Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

    David A. Braun;David A. Braun;Yue Hou;Ziad Bakouny;Miriam Ficial;Miriam Ficial

  • Resistance to checkpoint blockade therapy through inactivation of antigen presentation.

    Moshe Sade-Feldman;Moshe Sade-Feldman;Yunxin J. Jiao;Yunxin J. Jiao;Jonathan H. Chen;Jonathan H. Chen;Michael S. Rooney

  • Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

    Sachet A Shukla;Sachet A Shukla;Sachet A Shukla;Michael S Rooney;Michael S Rooney;Mohini Rajasagi;Grace Tiao

  • Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer.

    Kyle C. Strickland;Brooke E Howitt;Sachet A Shukla;Scott J. Rodig

  • Association of Polymerase e–Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1

    Brooke Elizabeth Howitt;Sachet Shukla;Lynette Marie Sholl;Lauren Lee Ritterhouse

  • The somatic genomic landscape of glioblastoma

    Cameron W. Brennan;Roel G. W. Verhaak;Aaron Mckenna;Benito Campos

  • Integrated genomic analyses of ovarian carcinoma

    D. Bell;A. Berchuck;M. Birrer;J. Chien

Frequent Co-Authors

Catherine J. Wu
Catherine J. Wu Harvard University
Gad Getz
Gad Getz Broad Institute
Nir Hacohen
Nir Hacohen Harvard University
Eliezer M. Van Allen
Eliezer M. Van Allen Harvard University
Levi A. Garraway
Levi A. Garraway Roche (United States)
Donna Neuberg
Donna Neuberg Harvard University
Eric S. Lander
Eric S. Lander Broad Institute
Sabina Signoretti
Sabina Signoretti Brigham and Women's Hospital
Toni K. Choueiri
Toni K. Choueiri Harvard University
Stacey Gabriel
Stacey Gabriel Broad Institute

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