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Biology and Biochemistry

D-Index
68
Citations
14434
World Ranking
7900
National Ranking
3585

Overview

Robert W. Ledeen is a researcher primarily affiliated with Rutgers, The State University of New Jersey in the United States. Their research focuses on areas within medicine and biochemistry, genetics, and molecular biology, with a particular emphasis on neurology and physiology. Their work also intersects with molecular biology, cell biology, and cellular and molecular neuroscience.

The main topics covered in their research include:

  • Lysosomal Storage Disorders Research
  • Parkinson's Disease Mechanisms and Treatments
  • Glycosylation and Glycoproteins Research
  • Cellular transport and secretion
  • Neurological disorders and treatments
  • Hereditary Neurological Disorders
  • Carbohydrate Chemistry and Synthesis

Frequent co-authors who collaborated with Robert W. Ledeen feature:

  • Suman Chowdhury
  • Gusheng Wu
  • Zihua Lu
  • Ranjeet Kumar
  • Samar K. Alselehdar

Their recent publications demonstrate a focus on Parkinson's disease and gangliosides, reflecting their research interests in neurodegenerative conditions and molecular mechanisms:

  • "Mice deficient in GM1 manifest both motor and non-motor symptoms of Parkinson's disease; successful treatment with synthetic GM1 ganglioside" (2020), Experimental Neurology
  • "The Key Role of GM1 Ganglioside in Parkinson's Disease" (2022), Biomolecules
  • "Systemic deficiency of GM1 ganglioside in Parkinson's disease tissues and its relation to the disease etiology" (2022), Glycoconjugate Journal
  • "Gangliosides in Neurodegenerative Diseases" (2022), Advances in Neurobiology
  • "Subnormal GM1 in PBMCs: Promise for Early Diagnosis of Parkinson's Disease?" (2021), International Journal of Molecular Sciences

Publication venues where Robert W. Ledeen has frequently published include:

  • International Journal of Molecular Sciences
  • Experimental Neurology
  • Biomolecules
  • Glycoconjugate Journal
  • Advances in Neurobiology

Best Publications

  • Gangliosides: structure, isolation, and analysis.

    Robert W. Ledeen;Robert K. Yu

  • GANGLIOSIDES OF HUMAN MYELIN: SIALOSYLGALACTOSYLCERAMIDE (G7) AS A MAJOR COMPONENT

    Robert Ledeen;R. K. Yu;L. F. Eng

  • Gangliosides of human, bovine, and rabbit plasma

    Robert K. Yu;Robert W. Ledeen

  • Gas–liquid chromatographic assay of lipid-bound sialic acids: measurement of gangliosides in brain of several species

    Robert K. Yu;Robert W. Ledeen

  • Biology of gangliosides: Neuritogenic and neuronotrophic properties

    R. W. Ledeen

  • Ganglioside structures and distribution: Are they localized at the nerve ending?

    Robert Ledeen

  • Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase.

    Goutam Chakraborty;Praveen Mekala;Daniel Yahya;Gusheng Wu

  • Gangliosides of the neuron

    Robert Ledeen

  • Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis

    Jianfeng Wang;Zi-Hua Lu;Hans-Joachim Gabius;Christine Rohowsky-Kochan

  • The multi-tasked life of GM1 ganglioside, a true factotum of nature

    Robert W. Ledeen;Gusheng Wu

  • Ganglioside‐Induced Neuritogenesis: Verification That Gangliosides Are the Active Agents, and Comparison of Molecular Species

    Mary C. Byrne;Robert W. Ledeen;Fred J. Roisen;Glee Yorke

  • Configuration of the ketosidic bond of sialic acid.

    Robert K. Yu;Robert Ledeen

  • Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

    Gusheng Wu;Zi-Hua Lu;Neil Kulkarni;Robert W. Ledeen;Robert W. Ledeen

  • The Role of GM1 and Other Gangliosides in Neuronal Differentiation Overview and New Findingsa

    Robert W. Ledeen;Gusheng Wu;Zi-Hua Lu;Diane Kozireski-Chuback

  • Structure of the Tay-Sachs' Ganglioside. I*

    Robert Ledeen;Kenneth Salsman

  • Properties of Antisera to Ganglioside GM1 and Asialo GM1

    Masaharu Naiki;Donald M. Marcus;Robert Ledeen

  • Structure of the human erythrocyte blood group P1 glycosphingolipid.

    Masaharu Naiki;Jones Fong;Robert Ledeen;Donald M. Marcus

  • Biosynthesis, Metabolism, and Biological Effects of Gangliosides

    Robert W. Ledeen

  • Gangliosides of bovine adrenal medulla.

    Robert. Ledeen;Kenneth. Salsman;Maria. Cabrera

  • Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.

    Gusheng Wu;Zi-Hua Lu;Jianfeng Wang;Yvette Wang

Frequent Co-Authors

Hans-Joachim Gabius
Hans-Joachim Gabius Ludwig-Maximilians-Universität München
Sabine André
Sabine André Ludwig-Maximilians-Universität München
Herbert Kaltner
Herbert Kaltner Ludwig-Maximilians-Universität München
Reuben Matalon
Reuben Matalon The University of Texas Medical Branch at Galveston
Robert K. Yu
Robert K. Yu Augusta University
Jürgen Kopitz
Jürgen Kopitz Heidelberg University
Hong Li
Hong Li Rutgers, The State University of New Jersey
Krystof S. Bankiewicz
Krystof S. Bankiewicz The Ohio State University
Stanley M. Crain
Stanley M. Crain Albert Einstein College of Medicine
Laura Mauri
Laura Mauri University of Milan

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