World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
14927
World Ranking
18556
National Ranking
7581

Research.com Recognitions

  • 1963 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Richard G. Carroll was affiliated with the University of Pennsylvania in the United States. Their research contributions spanned multiple fields, primarily focusing on medicine, biochemistry, genetics and molecular biology, and neuroscience. Carroll's work included significant investigation into endocrine and autonomic systems, cancer research, physiology, oncology, and hematology.

The scientist published extensively on topics such as circadian rhythm and melatonin, protease and inhibitor mechanisms, blood coagulation and thrombosis mechanisms, peptidase inhibition and analysis, asthma and respiratory diseases, genetics and aging in model organisms, and tryptophan and brain disorders.

Frequent publication venues for Carroll's work included the American Journal of Respiratory and Critical Care Medicine, with seven papers, followed by Nature Communications, Frontiers in Immunology, Seminars in Immunopathology, and The FASEB Journal.

Some of the recent papers authored or co-authored by Carroll included:

  • "Caspase-11 promotes allergic airway inflammation" (2020, Nature Communications)
  • "The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing" (2022, Nature Communications)
  • "The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1β" (2021, Frontiers in Immunology)
  • "Intertwining roles of circadian and metabolic regulation of the innate immune response" (2022, Seminars in Immunopathology)
  • "Circadian disruption in lung fibroblasts enhances NF-κB activity to exacerbate neutrophil recruitment" (2023, The FASEB Journal)

Carroll regularly collaborated with a network of co-authors including S.M. Roche, Annie M. Curtis, R.C. Heeney, James R. O'Siorain, and Rebecca C. Fitzgerald, contributing to multiple joint publications over their career.

The scientist was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1963.

Best Publications

  • Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

    Evanna L Mills;Dylan G Ryan;Hiran A Prag;Dina Dikovskaya

  • Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

    Michael C. Milone;Jonathan D. Fish;Jonathan D. Fish;Carmine Carpenito;Richard G. Carroll

  • Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

    Elena E. Perez;Jianbin Wang;Jeffrey C. Miller;Yann Jouvenot;Yann Jouvenot

  • Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

    Carmine Carpenito;Michael C. Milone;Raffit Hassan;Jacqueline C. Simonet

  • Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

    Edward Y. Woo;Heidi Yeh;Christina S. Chu;Katia Schlienger

  • Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor

    Yangbing Zhao;Edmund Moon;Carmine Carpenito;Chrystal M. Paulos

  • Engineering Artificial Antigen-presenting Cells to Express a Diverse Array of Co-stimulatory Molecules

    Megan M Suhoski;Tatiana N Golovina;Nicole A Aqui;Victoria C Tai

  • The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

    Chrystal M. Paulos;Carmine Carpenito;Gabriela Plesa;Megan M. Suhoski

  • Differential Regulation of HIV-1 Fusion Cofactor Expression by CD28 Costimulation of CD4+ T Cells

    Richard G. Carroll;James L. Riley;Bruce L. Levine;Yu Feng

  • Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

    Angel Varela-Rohena;Peter E. Molloy;Steven M. Dunn;Yi Li

  • Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

    David M. Barrett;Yangbing Zhao;Xiaojun Liu;Shuguang Jiang

  • Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.

    James O. Early;Deepthi Menon;Cathy A. Wyse;Mariana P. Cervantes-Silva

  • Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy

    Emilie Hollville;Richard G. Carroll;Sean P. Cullen;Seamus J. Martin

  • PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells

    Elena A. Goncharova;Alaina J. Ammit;Carla Irani;Richard G. Carroll

  • Inflammasome Priming in Sterile Inflammatory Disease.

    Meghana N. Patel;Richard G. Carroll;Silvia Galván-Peña;Silvia Galván-Peña;Evanna L. Mills;Evanna L. Mills

  • Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection.

    Bruce L. Levine;Wendy B. Bernstein;Wendy B. Bernstein;Naomi E. Aronson;Naomi E. Aronson;Katia Schlienger

  • A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses

    Daniel H. Sterman;Adri Recio;Richard G. Carroll;Colin T. Gillespie

  • CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function

    Tatiana N. Golovina;Tatiana Mikheeva;Megan M. Suhoski;Nicole A. Aqui

  • Tat-Associated Kinase, TAK, Activity Is Regulated by Distinct Mechanisms in Peripheral Blood Lymphocytes and Promonocytic Cell Lines

    Christine H. Herrmann;Richard G. Carroll;Ping Wei;Katherine A. Jones

  • Large-Scale Production of CD4+ T Cells from HIV-1-Infected Donors After CD3/CD28 Costimulation*

    Bruce L. Levine;Julio Cotte;Carolynn C. Small;Richard G. Carroll

Frequent Co-Authors

Carl H. June
Carl H. June University of Pennsylvania
James L. Riley
James L. Riley University of Pennsylvania
Bruce L. Levine
Bruce L. Levine University of Pennsylvania
Steven M. Albelda
Steven M. Albelda University of Pennsylvania
George Coukos
George Coukos Cornell University
Robert H. Vonderheide
Robert H. Vonderheide University of Pennsylvania
Larry R. Kaiser
Larry R. Kaiser Temple University
Stephan A. Grupp
Stephan A. Grupp Children's Hospital of Philadelphia
Michael C. Milone
Michael C. Milone University of Pennsylvania
Ira Pastan
Ira Pastan Center for Cancer Research

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Best Scientists Citing Richard G. Carroll