What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Internal medicine
The scientist’s investigation covers issues in Molecular biology, Hepatic stellate cell, Internal medicine, Cell culture and Fibrosis.
Procollagen peptidase is the focus of his Molecular biology research.
His Hepatic stellate cell study integrates concerns from other disciplines, such as Extracellular matrix, Transforming growth factor beta and Phagocytosis.
Mark A. Zern works mostly in the field of Internal medicine, limiting it down to concerns involving Endocrinology and, occasionally, Transplantation and Progenitor cell.
Mark A. Zern combines subjects such as Epithelial–mesenchymal transition, Cyclopamine, Cancer stem cell, Telomerase and Aldehyde dehydrogenase with his study of Cell culture.
His work carried out in the field of Gene expression brings together such families of science as Embryonic stem cell, Cellular differentiation and Hepatocyte.
His most cited work include:
- In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. (374 citations)
- Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells (251 citations)
- Hepatic stellate cells: a target for the treatment of liver fibrosis. (217 citations)
What are the main themes of his work throughout his whole career to date?
The scientist’s investigation covers issues in Molecular biology, Cell biology, Internal medicine, Pathology and Hepatocyte.
His study in Molecular biology is interdisciplinary in nature, drawing from both Cell culture, Gene expression, Hepatic stellate cell, Messenger RNA and Albumin.
Mark A. Zern has included themes like Embryonic stem cell, Apoptosis and Cellular differentiation in his Cell biology study.
His Internal medicine research is multidisciplinary, incorporating elements of Gastroenterology, Endocrinology and In vivo.
The Pathology study which covers Cirrhosis that intersects with Hepatitis and Liver disease.
The Hepatocyte study combines topics in areas such as Tissue transglutaminase, Liver injury and Liver transplantation.
He most often published in these fields:
- Molecular biology (32.90%)
- Cell biology (20.00%)
- Internal medicine (18.71%)
What were the highlights of his more recent work (between 2007-2021)?
- Cell biology (20.00%)
- Stem cell (11.61%)
- Cellular differentiation (10.97%)
In recent papers he was focusing on the following fields of study:
Mark A. Zern mostly deals with Cell biology, Stem cell, Cellular differentiation, Cancer research and Molecular biology.
His studies deal with areas such as Embryonic stem cell and Hepatocyte as well as Cell biology.
His study looks at the relationship between Cellular differentiation and topics such as Mesenchymal stem cell, which overlap with Cholangiocyte.
His Cancer research research includes elements of Epithelial–mesenchymal transition, Gene silencing, microRNA and Immunology.
Mark A. Zern has researched Molecular biology in several fields, including Cell culture, Hepatic stellate cell, Hepatocyte growth factor, Apoptosis and Extracellular matrix.
His Signal transduction research incorporates themes from Endocrinology and Internal medicine.
Between 2007 and 2021, his most popular works were:
- Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation (170 citations)
- Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells. (140 citations)
- EPITHELIAL MESENCHYMAL TRANSITION AND HEDGEHOG SIGNALING ACTIVATION ARE ASSOCIATED WITH CHEMORESISTANCE AND INVASION OF HEPATOMA SUBPOPULATIONS (131 citations)
In his most recent research, the most cited papers focused on:
Stem cell, Cellular differentiation, Molecular biology, Embryonic stem cell and Hepatocyte are his primary areas of study.
His research in Stem cell intersects with topics in Hepatoblastoma and Pathology.
His studies deal with areas such as Gene silencing and Induced pluripotent stem cell as well as Cellular differentiation.
His study in Molecular biology is interdisciplinary in nature, drawing from both Epithelial–mesenchymal transition, Cell culture, Hepatic stellate cell, Hepatocyte growth factor and Extracellular matrix.
His Hepatic stellate cell research incorporates elements of Apoptosis, Liver cell, Alcoholic liver disease and Liver injury.
His work on Hepatocyte differentiation as part of general Hepatocyte study is frequently linked to Hepatocyte nuclear factor 4, bridging the gap between disciplines.
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