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Biology and Biochemistry

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62
Citations
12309
World Ranking
10914
National Ranking
4727

Overview

Mark A. Zern is affiliated with the University of California, Davis in the United States. Their research focuses primarily on fields related to medicine and biochemistry, genetics, and molecular biology. Within these areas, key subfields include molecular biology, surgery, hepatology, biomedical engineering, and cancer research.

The scientist's work covers several main topics, prominently including tissue engineering and regenerative medicine, extracellular vesicles in disease, liver physiology and pathology, pluripotent stem cells research, 3D printing in biomedical research, and microRNA in disease regulation.

Recent publications by Mark A. Zern reflect these interests and research specializations. Notable papers include:

  • "3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway," 2021, Journal of Nanobiotechnology
  • "Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway," 2022, Stem Cell Research & Therapy
  • "The combination of dextran sulphate and polyvinyl alcohol prevents excess aggregation and promotes proliferation of pluripotent stem cells in suspension culture," 2021, Cell Proliferation
  • "3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway," 2021, Research Square (Research Square)
  • "Corrigendum to Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms Cellular Signaling, 2007, 2339-2350, 07.013," 2021, Cellular Signalling

Frequent publication venues for this researcher include:

  • Stem Cell Research & Therapy
  • Journal of Nanobiotechnology
  • Cell Proliferation
  • Research Square (Research Square)
  • Cellular Signalling

Collaborations form an important part of their work. Frequent co-authors are:

  • Yaqi Qiu
  • Haibin Wu
  • Xianglian Tang
  • Qicong Chen
  • Honglin Chen

Mark A. Zern's contributions mainly address complex biological systems involving stem cells, liver disease mechanisms, and regenerative medicine, with an emphasis on molecular pathways and cellular behaviors that impact tissue repair and disease progression.

Best Publications

  • In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.

    Mark J. Czaja;Francis R. Weiner;Kathleen C. Flanders;Marie-Adele Giambrone

  • Hepatic stellate cells: a target for the treatment of liver fibrosis.

    Jian Wu;Mark A. Zern

  • Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells

    Michal Zalzman;Sanjeev Gupta;Ranjit K. Giri;Irina Berkovich

  • Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

    Shan‐Shan Zhan;Joy X. Jiang;Jian Wu;Charles Halsted

  • Collagen chain mRNAs in isolated heart cells from young and adult rats

    Mahboubeh Eghbali;Mark J. Czaja;Maria Zeydel;Francis R. Weiner

  • Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation

    Senthil Kumar Venugopal;Joy Jiang;Tae-Hun Kim;Yong Li

  • SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity

    Henning Wege;Michael S. Chui;Hai T. Le;Julie M. Tran

  • Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization

    M. Eghbali;O. O. Blumenfeld;S. Seifter;P. M. Buttrick

  • Differentiation and Enrichment of Hepatocyte‐Like Cells from Human Embryonic Stem Cells In Vitro and In Vivo

    Yuyou Duan;Andreea Catana;Ying Meng;Naoki Yamamoto

  • Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis.

    Jianliang Zhu;Jian Wu;Edward Frizell;Shu-Ling Liu

  • Ito-cell gene expression and collagen regulation

    Francis R. Weiner;Marie‐Adele ‐A Giambrone;Mark J. Czaja;Anish Shah

  • Targeting hepatocytes for drug and gene delivery: emerging novel approaches and applications.

    Jian Wu;Michael H Nantz;Mark A Zern

  • γ‐interferon treatment inhibits collagen deposition in murine schistosomiasis

    M. J. Czaja;F. R. Weiner;S. Takahashi;M. A. Giambrone

  • Fish Oil, Alcohol, and Liver Pathology: Role of Cytochrome P450 2E1:

    M. Morimoto;Mark A Zern;A. L. Hagbjork;M. Ingelman-Sundberg

  • Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential

    Henning Wege;Hai T. Le;Michael S. Chui;Li Liu

  • EPITHELIAL MESENCHYMAL TRANSITION AND HEDGEHOG SIGNALING ACTIVATION ARE ASSOCIATED WITH CHEMORESISTANCE AND INVASION OF HEPATOMA SUBPOPULATIONS

    Xiaoli Chen;Shilpa Lingala;Shiva Khoobyari;Jan Nolta

  • Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage.

    Hitoshi Shirahashi;Jian Wu;Naoki Yamamoto;Andreea Catana

  • A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB

    Ahmed Mirza;Shu Ling Liu;Eduardo Frizell;Jianling Zhu

  • Vitamin E therapy of acute CCl4‐induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding

    Shu Ling Liu;Silvia Degli Esposti;Tony Yao;Anna Mae Diehl

  • Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells.

    YuYou Duan;Xiaochui Ma;W. E I Zou;Charles Wang

Frequent Co-Authors

Jian Wu
Jian Wu Fudan University
Alexander Revzin
Alexander Revzin Mayo Clinic
Jan A. Nolta
Jan A. Nolta University of California, Davis
Roger J. Pomerantz
Roger J. Pomerantz ContraFect (United States)
Giovanni Gasbarrini
Giovanni Gasbarrini University of Bologna
Antonio Gasbarrini
Antonio Gasbarrini Catholic University of the Sacred Heart
Naoki Yamamoto
Naoki Yamamoto National University of Singapore
John J. Rossi
John J. Rossi City Of Hope National Medical Center
Antonia Follenzi
Antonia Follenzi University of Eastern Piedmont Amadeo Avogadro
Peggy J. Farnham
Peggy J. Farnham University of Southern California

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