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Overview

Mario L. Santiago is affiliated with the University of Colorado Denver in the United States. Their research spans the fields of immunology and microbiology as well as medicine, reflecting a multidisciplinary approach to infectious diseases and immune system function.

Their scientific contributions cover several subfields, including immunology, infectious diseases, molecular biology, virology, and epidemiology. This broad scope indicates an active engagement with both basic and applied biomedical research, with particular attention to viral infections and immune responses.

Santiago's main research topics include:

  • HIV research and treatment
  • Immune cell function and interaction
  • SARS-CoV-2 and COVID-19 research
  • Cytomegalovirus and herpesvirus research
  • COVID-19 clinical research studies
  • RNA research and splicing
  • Interferon and immune responses

Their recent publications demonstrate a focus on viral pathogenesis and immune mechanisms related to SARS-CoV-2 and other viruses. Notable papers include:

  • Interferon resistance of emerging SARS-CoV-2 variants, 2022, Proceedings of the National Academy of Sciences
  • Specialized interferon action in COVID-19, 2022, Proceedings of the National Academy of Sciences
  • Interferon Resistance of Emerging SARS-CoV-2 Variants, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques, 2021, mBio
  • Qualitative Differences Between the IFNα subtypes and IFNβ Influence Chronic Mucosal HIV-1 Pathogenesis, 2020, PLoS Pathogens

Santiago frequently collaborates with several co-authors who have contributed to multiple publications, including Kejun Guo, Bradley S. Barrett, Kaylee L. Mickens, Stephanie M. Dillon, and Kathrin Sutter.

Their work is published across various journals, with multiple articles appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • PLoS Pathogens
  • Journal of Virology
  • Proceedings of the National Academy of Sciences

Best Publications

  • Chimpanzee reservoirs of pandemic and nonpandemic HIV-1.

    Brandon F. Keele;Fran Van Heuverswyn;Yingying Li;Elizabeth Bailes

  • Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

    Gilad Doitsh;Marielle Cavrois;Kara G. Lassen;Orlando Zepeda

  • Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.

    Michael Schindler;Jan Münch;Olaf Kutsch;Hui Li

  • The origins of acquired immune deficiency syndrome viruses: where and when?

    Paul M. Sharp;Elizabeth Bailes;Roy R. Chaudhuri;Cynthia M. Rodenburg

  • Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis

    Joris Hemelaar;Ramyiadarsini Elangovan;Jason Yun;Leslie Dickson-Tetteh

  • Simian Immunodeficiency Virus Infection in Free-Ranging Sooty Mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: Implications for the Origin of Epidemic Human Immunodeficiency Virus Type 2

    Mario L. Santiago;Friederike Range;Brandon F. Keele;Yingying Li

  • High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition

    Ya-Lin Chiu;H. Ewa Witkowska;Steven C. Hall;Mario Santiago

  • SIVcpz in wild chimpanzees

    Mario L. Santiago;Cynthia M. Rodenburg;Shadrack Kamenya;Frederic Bibollet-Ruche;Frederic Bibollet-Ruche

  • APOBEC3A Functions as a Restriction Factor of Human Papillomavirus

    Cody J. Warren;Tao Xu;Kejun Guo;Laura M. Griffin

  • Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation.

    Stephanie M. Dillon;Jon Kibbie;Eric J. Lee;Kejun Guo

  • Molecular ecology and natural history of Simian foamy virus infection in wild-living chimpanzees

    Weimin Liu;Michael Worobey;Yingying Li;Brandon F. Keele

  • Foci of Endemic Simian Immunodeficiency Virus Infection in Wild-Living Eastern Chimpanzees (Pan troglodytes schweinfurthii)

    Mario L. Santiago;Magdalena Lukasik;Shadrack Kamenya;Yingying Li

  • Apobec3 Encodes Rfv3, a Gene Influencing Neutralizing Antibody Control of Retrovirus Infection

    Mario L. Santiago;Mauricio Montano;Robert Benitez;Ronald J. Messer

  • Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo

    Kerry J. Lavender;Kathrin Gibbert;Karin E. Peterson;Erik Van Dis

  • Origin of AIDS: contaminated polio vaccine theory refuted.

    Michael Worobey;Mario L. Santiago;Brandon F. Keele;Jean Bosco N. Ndjango

  • Compartmentalization of Simian Immunodeficiency Virus Replication within Secondary Lymphoid Tissues of Rhesus Macaques Is Linked to Disease Stage and Inversely Related to Localization of Virus-Specific CTL

    Elizabeth Connick;Joy M. Folkvord;Katherine T. Lind;Eva G. Rakasz

  • SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.

    Shuliang Chen;Shuliang Chen;Serena Bonifati;Zhihua Qin;Corine St. Gelais

  • Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms.

    Michael S. Harper;Kejun Guo;Kathrin Gibbert;Eric J. Lee

  • Identification of the Schistosoma japonicum 22.6–kDa Antigen as a Major Target of the Human IgE Response: Similarity of IgE–Binding Epitopes to Allergen Peptides

    M. L. Santiago;J. C. R. Hafalla;J. D. Kurtis;G. L. Aligui

  • Amplification of a Complete Simian Immunodeficiency Virus Genome from Fecal RNA of a Wild Chimpanzee

    Mario L. Santiago;Frederic Bibollet-Ruche;Elizabeth Bailes;Shadrack Kamenya

Frequent Co-Authors

Beatrice H. Hahn
Beatrice H. Hahn University of Pennsylvania
Frederic Bibollet-Ruche
Frederic Bibollet-Ruche University of Pennsylvania
Paul M. Sharp
Paul M. Sharp University of Edinburgh
Martine Peeters
Martine Peeters Institut de Recherche pour le Développement
David W. Dunne
David W. Dunne University of Cambridge
Jan Münch
Jan Münch University of Ulm
Ahidjo Ayouba
Ahidjo Ayouba Institut de Recherche pour le Développement
Daniel N. Frank
Daniel N. Frank University of Colorado Anschutz Medical Campus
Frank Kirchhoff
Frank Kirchhoff University of Ulm
Edward D. Barker
Edward D. Barker King's College London

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