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Biology and Biochemistry

D-Index
70
Citations
14969
World Ranking
7124
National Ranking
3270

Overview

David L. Keefe is affiliated with Brown University in the United States. Their research spans multiple fields related to medicine, biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, reproductive medicine, pediatrics, perinatology, and physiology.

Their main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their subfields of study focus on:

  • Molecular Biology
  • Pediatrics, Perinatology and Child Health
  • Physiology
  • Public Health, Environmental and Occupational Health
  • Reproductive Medicine

The scientist's key research topics cover:

  • Telomeres, Telomerase, and Senescence
  • Reproductive Biology and Fertility
  • Prenatal Screening and Diagnostics
  • CRISPR and Genetic Engineering
  • Chromosomal and Genetic Variations
  • Ovarian function and disorders
  • Assisted Reproductive Technology and Twin Pregnancy

David L. Keefe has authored numerous publications, with recent notable papers including:

  • Characteristics and Outcomes of 241 Births to Women With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection at Five New York City Medical Centers, 2020, Obstetrics and Gynecology
  • Widespread Transcriptional Scanning in the Testis Modulates Gene Evolution Rates, 2020, Cell
  • Molecular Features of Polycystic Ovary Syndrome Revealed by Transcriptome Analysis of Oocytes and Cumulus Cells, 2021, Frontiers in Cell and Developmental Biology
  • The reproducibility of trophectoderm biopsies in euploid, aneuploid, and mosaic embryos using independently verified next-generation sequencing (NGS): a pilot study, 2020, Journal of Assisted Reproduction and Genetics
  • Control of LINE-1 Expression Maintains Genome Integrity in Germline and Early Embryo Development, 2021, Reproductive Sciences

The scientist frequently publishes in the following venues:

  • Fertility and Sterility
  • Journal of Assisted Reproduction and Genetics
  • Obstetrical & Gynecological Survey
  • Human Reproduction
  • Reproductive Sciences

Frequent collaborators in their research include:

  • David H. McCulloh
  • J. Grifo
  • Fabiana B. Kohlrausch
  • Paula Andrea Navarro
  • Thalita S. Berteli

Best Publications

  • Physician Referral for Fertility Preservation in Oncology Patients: A National Study of Practice Behaviors

    Gwendolyn P. Quinn;Susan T. Vadaparampil;Ji Hyun Lee;Paul B. Jacobsen

  • Telomere lengthening early in development.

    Lin Liu;Susan M. Bailey;Maja Okuka;Purificación Muñoz

  • Mitochondrial deoxyribonucleic acid deletions in oocytes and reproductive aging in women

    David L. Keefe;Tracy Niven-Fairchild;Susan Powell;Syam Buradagunta

  • Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

    Suneet Agarwal;Suneet Agarwal;Yuin-Han Loh;Yuin-Han Loh;Erin M. McLoughlin;Erin M. McLoughlin;Junjiu Huang;Junjiu Huang

  • Quantification of hormone pulsatility via an approximate entropy algorithm

    Steven M. Pincus;David L. Keefe

  • Involvement of Mitochondria in Oxidative Stress-Induced Cell Death in Mouse Zygotes

    Lin Liu;James R. Trimarchi;James R. Trimarchi;David L. Keefe;David L. Keefe

  • Limited recovery of meiotic spindles in living human oocytes after cooling–rewarming observed using polarized light microscopy

    Wei-Hua Wang;Li Meng;Rickard J. Hackett;Rudolf Odenbourg

  • Oxidative Phosphorylation-Dependent and -Independent Oxygen Consumption by Individual Preimplantation Mouse Embryos

    James R. Trimarchi;Lin Liu;Lin Liu;D. Marshall Porterfield;Peter J.S. Smith

  • Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability and apoptosis

    Lin Liu;Lin Liu;James R. Trimarchi;James R. Trimarchi;Paula Navarro;Maria A. Blasco

  • The spindle observation and its relationship with fertilization after intracytoplasmic sperm injection in living human oocytes.

    Wei-Hua Wang;Li Meng;Rickard J Hackett;Rudolf Odenbourg

  • Müllerian inhibiting substance levels at the time of HCG administration in IVF cycles predict both ovarian reserve and embryo morphology

    T. Silberstein;D.T. MacLaughlin;I. Shai;J.R. Trimarchi

  • Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women.

    Anna-Riitta Fuchs;Roberto Romero;David Keefe;Manuel Parra

  • Mitochondrial dysfunction leads to telomere attrition and genomic instability

    Lin Liu;James R. Trimarchi;Peter J. S. Smith;David L. Keefe

  • An Essential Role for Functional Telomeres in Mouse Germ Cells during Fertilization and Early Development

    Lin Liu;Maria A. Blasco;James R. Trimarchi;James R. Trimarchi;David L. Keefe;David L. Keefe

  • A reliable, noninvasive technique for spindle imaging and enucleation of mammalian oocytes.

    Lin Liu;Lin Liu;Rudolf Oldenbourg;James R. Trimarchi;James R. Trimarchi;David L. Keefe;David L. Keefe

  • Delay in oocyte aging in mice by the antioxidant N-acetyl-l-cysteine (NAC)

    Jinmiao Liu;Mengyuan Liu;Xiaoying Ye;Kai Liu

  • Oocyte competency is the key to embryo potential.

    David Keefe;Molly Kumar;Keri Kalmbach

  • Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling

    Nina S. Stachenfeld;Andres E. Splenser;Wendy L. Calzone;Matthew P. Taylor

  • The telomere theory of reproductive senescence in women.

    David L Keefe;Kerri Marquard;Lin Liu

  • Hormone replacement therapy may alleviate sleep apnea in menopausal women: a pilot study.

    David L. Keefe;Robert Watson;Frederick Naftolin

Frequent Co-Authors

Lin Liu
Lin Liu Chinese Academy of Sciences
Peter Smith
Peter Smith University of Aberdeen
Frederick Naftolin
Frederick Naftolin New York University
Maria A. Blasco
Maria A. Blasco Spanish National Cancer Research Centre
Hugh S. Taylor
Hugh S. Taylor Yale University
Carolyn M. Mazure
Carolyn M. Mazure Yale University
Luis M. Garcia-Segura
Luis M. Garcia-Segura Spanish National Research Council
Lawrence Scahill
Lawrence Scahill Emory University
Donald J. Cohen
Donald J. Cohen Yale University
Linda C. Giudice
Linda C. Giudice University of California, San Francisco

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